Efficacy and safety of cisplatin plus pemetrexed as a first-line treatment for japanese patients with advanced non-squamous non-small-cell lung cancer-a retrospective analysis

Teppei Yamaguchi, Toru Nakanishi, Masamichi Hayashi, Sakurako Uozu, Takuya Okamura, Mariko Morishita, Tomoko Takeyama, Tomoyuki Minezawa, Sayako Morikawa, Yoshikazu Niwa, Yuki Mieno, Atsushi Kato, Tami Hoshino, Sumito Isogai, Mitsushi Okazawa, Kazuyoshi Imaizumi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Cisplatin plus pemetrexed is considered the standard of care for the first-line treatment of patients with advnced non-squamous non-small-cell lung cancer (NSCLC). However, little is known about the efficacy and safety of this regicnen in Japanese patients in a daily clinical setting. Methods: We retrospectively analyzed 40 patients who received cisplatin (75 mg/m2) and pernetrexed (500 mg/m2) as a first-line treatment for advanced non-squamous NSCLC. Results: Recorded Grade 3 or 4 hernatological toxicities included neutropenia in 7 cases (17.5%), leukopenia in 5 cases (12.5%), anernia in 1 case (2.5%), thrombocytopenia in 1 case (2.5%), and febrile neutropenia in 1 case (2.5%). Grade 3 or 4 nonhematological toxicities included anorexia in 3 cases (7.5%), infection in 1 case (2.5%), rash in 1 case (2.5%), and increased transaminase expression in 1 case (2.5%). Therefore, the adverse events were mostly mild. There were no treatment- related deaths. The overall response rate was 37.5%, median progression free survival was 5.6 months, and median overall suMval (OS) was 18.8 months. In an epidermal growth factor receptor (EGFR) mutation status subgroup analysis, the median OS of patients with wild-type EGFR or unknown status (n28) was 16.8 months. Conclusion: Cisplatin plus pemetrexed was well tolerated as a first-line treatment and effective in Japanese patients with advanced non-squamous NSCLC.

Original languageEnglish
Pages (from-to)183-187
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume42
Issue number2
Publication statusPublished - 01-02-2015

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Yamaguchi, T., Nakanishi, T., Hayashi, M., Uozu, S., Okamura, T., Morishita, M., Takeyama, T., Minezawa, T., Morikawa, S., Niwa, Y., Mieno, Y., Kato, A., Hoshino, T., Isogai, S., Okazawa, M., & Imaizumi, K. (2015). Efficacy and safety of cisplatin plus pemetrexed as a first-line treatment for japanese patients with advanced non-squamous non-small-cell lung cancer-a retrospective analysis. Japanese Journal of Cancer and Chemotherapy, 42(2), 183-187.