Efficacy of atorvastatin therapy in ischaemic heart disease - Effects on oxidized low-density lipoprotein and adiponectin

K. Miyagishima, Shinya Hiramitsu, S. Kato, Y. Kato, F. Kitagawa, R. Teradaira, R. Shinohara, K. Mori, H. Kimura, T. Ueda, M. Ohtsuki, S. Morimoto, H. Hishida

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The lipid-lowering and anti-atherosclerotic effects of atorvastatin (10 mg/day) were investigated by measuring changes in the levels of oxidized low-density lipoprotein (LDL), serum lipids (total cholesterol [TC], LDL-cholesterol [LDL-C] and triglycerides [TG]), and in the protein adiponectin. This was undertaken in 22 patients with ischaemic heart disease and serum LDL-C levels > 100 mg/dl. After 3 months of therapy, atorvastatin significantly decreased serum lipids, oxidized LDL was reduced from 457.0 ± 148.6 to 286.9 ± 88.5 nmol/l, and adiponectin increased from 9.7 ± 7.4 to 13.9 ± 9.98 μg/ ml. No significant correlation was observed between adiponectin and LDL-C, TG and high-density lipoprotein cholesterol. Atorvastatin therapy was not associated with side-effects, such as myalgia and gastrointestinal disorders, and did not give abnormal laboratory test results. It is concluded that atorvastatin decreases serum lipid and oxidized LDL levels, and increases adiponectin levels in patients with ischaemic heart disease.

Original languageEnglish
Pages (from-to)534-539
Number of pages6
JournalJournal of International Medical Research
Volume35
Issue number4
DOIs
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Efficacy of atorvastatin therapy in ischaemic heart disease - Effects on oxidized low-density lipoprotein and adiponectin'. Together they form a unique fingerprint.

  • Cite this

    Miyagishima, K., Hiramitsu, S., Kato, S., Kato, Y., Kitagawa, F., Teradaira, R., Shinohara, R., Mori, K., Kimura, H., Ueda, T., Ohtsuki, M., Morimoto, S., & Hishida, H. (2007). Efficacy of atorvastatin therapy in ischaemic heart disease - Effects on oxidized low-density lipoprotein and adiponectin. Journal of International Medical Research, 35(4), 534-539. https://doi.org/10.1177/147323000703500413