Efficacy of docetaxel in patients with paclitaxel-resistant advanced gastric cancer

Chihiro Kondoh, Daisuke Takahari, Kohei Shitara, Ayako Mizota, Motoo Nomura, Tomoya Yokota, Takashi Ura, Seiji Ito, Hiroki Kawai, Akira Sawaki, Kei Muro

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background: Although there appears to be incomplete cross-resistance between docetaxel and paclitaxel in several types of malignancies, to our best knowledge there have been no available data on this for advanced gastric cancer. Methods: We retrospectively evaluated the efficacy and safety of docetaxel in patients with paclitaxel-resistant advanced gastric cancer. Docetaxel was administered at 50-60 mg/m2 every 3 weeks. Results: Twenty-one patients were evaluated. All patients had received 2 or more previous chemotherapy regimens. Among the 12 patients with measurable lesions, apparent tumor shrinkage was seen in 1 patient for an overall response rate of 8.3% and a disease control rate of 33.3%. Median progression free survival and overall survival of all patients were 2.6 months and 6.7 months, respectively. There were no correlations between the progression free survival of docetaxel and the progression free survival of previous paclitaxel and between the progression free survival of docetaxel and taxane-free interval (Spearman's correlation coefficients of ρ = -0.14 and ρ = -0.02, respectively). Grade 3/4 neutropenia developed in 8 patients (38%) and Grade 3 febrile neutropenia in 1 patient (4.8%). Conclusions: Docetaxel showed modest activity in paclitaxel-resistant advanced gastric cancer patients, and no correlations between previous efficacy of paclitaxel or taxane-free interval were seen.

Original languageEnglish
Pages (from-to)1511-1515
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume39
Issue number10
Publication statusPublished - 10-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Efficacy of docetaxel in patients with paclitaxel-resistant advanced gastric cancer'. Together they form a unique fingerprint.

Cite this