Abstract
Background and Aims: Endoscopic balloon dilation [EBD] is an alternative to surgery for Crohn's strictures. However, there have been no prospective studies of EBD for small bowel strictures in patients with Crohn's disease [CD]. The aim of this study was to clarify the efficacy and safety of EBD using balloon-assisted enteroscopy for small bowel strictures in CD.
Methods: This was a nationwide, multi-centre, open-label, prospective cohort study. The subjects were CD patients with at least one symptom [abdominal pain, abdominal bloating, nausea] attributable to small bowel stricture. The primary endpoint related to short-term outcomes was the level of improvement of symptoms evaluated using a 10-cm visual analogue scale [VAS]. Cases in which VAS scores for all symptoms improved 4 weeks after EBD compared with baseline were considered to have short-term symptomatic improvement. Factors related to short-term treatment outcomes and safety were investigated as secondary endpoints.
Results: A total of 112 patients were enrolled. Seventeen were later excluded because they did not meet the criteria, and the analysis was conducted with the remaining 95 patients. Of these 95 patients, procedure failure occurred in six [6.3%], and short-term symptomatic improvement was achieved in 66 patients [69.5%]. Adverse events were seen in five patients [5%] and all of these improved with conservative treatment. A large dilation diameter of the balloon was a factor contributing to the success of EBD.
Conclusions: EBD using balloon-assisted enteroscopy for small bowel strictures in CD patients was shown to be an effective and safe procedure.
Clinical trial registry: UMIN000005946.
| Original language | English |
|---|---|
| Pages (from-to) | 394-401 |
| Number of pages | 8 |
| Journal | Journal of Crohn's & colitis |
| Volume | 12 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 28-03-2018 |
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All Science Journal Classification (ASJC) codes
- Gastroenterology
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Efficacy of Endoscopic Balloon Dilation for Small Bowel Strictures in Patients With Crohn's Disease : A Nationwide, Multi-centre, Open-label, Prospective Cohort Study. / Hirai, Fumihito; Andoh, Akira; Ueno, Fumiaki; Watanabe, Kenji; Omiya, Naoki; Nakase, Hiroshi; Kato, Shingo; Esaki, Motohiro; Endo, Yutaka; Yamamoto, Hironori; Matsui, Toshiyuki; Iida, Mitsuo; Hibi, Toshifumi; Watanabe, Mamoru; Suzuki, Yasuo; Matsumoto, Takayuki.
In: Journal of Crohn's & colitis, Vol. 12, No. 4, 28.03.2018, p. 394-401.Research output: Contribution to journal › Article
TY - JOUR
T1 - Efficacy of Endoscopic Balloon Dilation for Small Bowel Strictures in Patients With Crohn's Disease
T2 - A Nationwide, Multi-centre, Open-label, Prospective Cohort Study
AU - Hirai, Fumihito
AU - Andoh, Akira
AU - Ueno, Fumiaki
AU - Watanabe, Kenji
AU - Omiya, Naoki
AU - Nakase, Hiroshi
AU - Kato, Shingo
AU - Esaki, Motohiro
AU - Endo, Yutaka
AU - Yamamoto, Hironori
AU - Matsui, Toshiyuki
AU - Iida, Mitsuo
AU - Hibi, Toshifumi
AU - Watanabe, Mamoru
AU - Suzuki, Yasuo
AU - Matsumoto, Takayuki
PY - 2018/3/28
Y1 - 2018/3/28
N2 - Background and Aims: Endoscopic balloon dilation [EBD] is an alternative to surgery for Crohn's strictures. However, there have been no prospective studies of EBD for small bowel strictures in patients with Crohn's disease [CD]. The aim of this study was to clarify the efficacy and safety of EBD using balloon-assisted enteroscopy for small bowel strictures in CD.Methods: This was a nationwide, multi-centre, open-label, prospective cohort study. The subjects were CD patients with at least one symptom [abdominal pain, abdominal bloating, nausea] attributable to small bowel stricture. The primary endpoint related to short-term outcomes was the level of improvement of symptoms evaluated using a 10-cm visual analogue scale [VAS]. Cases in which VAS scores for all symptoms improved 4 weeks after EBD compared with baseline were considered to have short-term symptomatic improvement. Factors related to short-term treatment outcomes and safety were investigated as secondary endpoints.Results: A total of 112 patients were enrolled. Seventeen were later excluded because they did not meet the criteria, and the analysis was conducted with the remaining 95 patients. Of these 95 patients, procedure failure occurred in six [6.3%], and short-term symptomatic improvement was achieved in 66 patients [69.5%]. Adverse events were seen in five patients [5%] and all of these improved with conservative treatment. A large dilation diameter of the balloon was a factor contributing to the success of EBD.Conclusions: EBD using balloon-assisted enteroscopy for small bowel strictures in CD patients was shown to be an effective and safe procedure.Clinical trial registry: UMIN000005946.
AB - Background and Aims: Endoscopic balloon dilation [EBD] is an alternative to surgery for Crohn's strictures. However, there have been no prospective studies of EBD for small bowel strictures in patients with Crohn's disease [CD]. The aim of this study was to clarify the efficacy and safety of EBD using balloon-assisted enteroscopy for small bowel strictures in CD.Methods: This was a nationwide, multi-centre, open-label, prospective cohort study. The subjects were CD patients with at least one symptom [abdominal pain, abdominal bloating, nausea] attributable to small bowel stricture. The primary endpoint related to short-term outcomes was the level of improvement of symptoms evaluated using a 10-cm visual analogue scale [VAS]. Cases in which VAS scores for all symptoms improved 4 weeks after EBD compared with baseline were considered to have short-term symptomatic improvement. Factors related to short-term treatment outcomes and safety were investigated as secondary endpoints.Results: A total of 112 patients were enrolled. Seventeen were later excluded because they did not meet the criteria, and the analysis was conducted with the remaining 95 patients. Of these 95 patients, procedure failure occurred in six [6.3%], and short-term symptomatic improvement was achieved in 66 patients [69.5%]. Adverse events were seen in five patients [5%] and all of these improved with conservative treatment. A large dilation diameter of the balloon was a factor contributing to the success of EBD.Conclusions: EBD using balloon-assisted enteroscopy for small bowel strictures in CD patients was shown to be an effective and safe procedure.Clinical trial registry: UMIN000005946.
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U2 - 10.1093/ecco-jcc/jjx159
DO - 10.1093/ecco-jcc/jjx159
M3 - Article
VL - 12
SP - 394
EP - 401
JO - Journal of Crohn's and Colitis
JF - Journal of Crohn's and Colitis
SN - 1873-9946
IS - 4
ER -