EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy

Fumio Kataoka; Hiroshi Tsuda; Tokuzo Arao; Sadako Nishimura; Hideo Tanaka; Hiroyuki Nomura; Tatsuyuki Chiyoda; Akira Hirasawa; Tomoko Akahane; Hiroshi Nishio; Kazuto Nishio; Daisuke Aoki

doi:10.1002/gcc.21916

EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy

Fumio Kataoka, Hiroshi Tsuda, Tokuzo Arao, Sadako Nishimura, Hideo Tanaka, Hiroyuki Nomura, Tatsuyuki Chiyoda, Akira Hirasawa, Tomoko Akahane, Hiroshi Nishio, Kazuto Nishio, Daisuke Aoki

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32 Citations (Scopus)

Abstract

Stromal components interact with cancer cells to promote growth and metastasis. The purpose of this study was to identify genes expressed in stroma, which could provide prognostic information in epithelial ovarian cancer (EOC). Seventy-four patients were included. We performed gene expression profiling and confirmed array data using RT-PCR and immunohistochemistry. By microarray analysis, 52 candidate genes associated with progression free survival (PFS) were identified (P < 0.005). Expression of the early growth response 1 (EGR1) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) genes was further analyzed. Array data were confirmed by RT-PCR and multivariate analysis demonstrated that both EGR1 and FOSB expression in cancer stroma, and EGR1 expression in cancer are independent prognostic factors in EOC. Immunohistochemically, EGR1 protein is localized in cancer cells and α-smooth muscle actin positive stromal fibroblasts. The EGR1 and FOSB expression in stromal cells and EGR1 expression in cancer cells are prognostic indicators in EOC.

Original language	English
Pages (from-to)	300-312
Number of pages	13
Journal	Genes Chromosomes and Cancer
Volume	51
Issue number	3
DOIs	https://doi.org/10.1002/gcc.21916
Publication status	Published - 03-2012
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics
Cancer Research

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10.1002/gcc.21916

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Kataoka, F., Tsuda, H., Arao, T., Nishimura, S., Tanaka, H., Nomura, H., Chiyoda, T., Hirasawa, A., Akahane, T., Nishio, H., Nishio, K., & Aoki, D. (2012). EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy. Genes Chromosomes and Cancer, 51(3), 300-312. https://doi.org/10.1002/gcc.21916

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title = "EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy",

abstract = "Stromal components interact with cancer cells to promote growth and metastasis. The purpose of this study was to identify genes expressed in stroma, which could provide prognostic information in epithelial ovarian cancer (EOC). Seventy-four patients were included. We performed gene expression profiling and confirmed array data using RT-PCR and immunohistochemistry. By microarray analysis, 52 candidate genes associated with progression free survival (PFS) were identified (P < 0.005). Expression of the early growth response 1 (EGR1) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) genes was further analyzed. Array data were confirmed by RT-PCR and multivariate analysis demonstrated that both EGR1 and FOSB expression in cancer stroma, and EGR1 expression in cancer are independent prognostic factors in EOC. Immunohistochemically, EGR1 protein is localized in cancer cells and α-smooth muscle actin positive stromal fibroblasts. The EGR1 and FOSB expression in stromal cells and EGR1 expression in cancer cells are prognostic indicators in EOC.",

author = "Fumio Kataoka and Hiroshi Tsuda and Tokuzo Arao and Sadako Nishimura and Hideo Tanaka and Hiroyuki Nomura and Tatsuyuki Chiyoda and Akira Hirasawa and Tomoko Akahane and Hiroshi Nishio and Kazuto Nishio and Daisuke Aoki",

year = "2012",

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doi = "10.1002/gcc.21916",

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journal = "Genes Chromosomes and Cancer",

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Kataoka, F, Tsuda, H, Arao, T, Nishimura, S, Tanaka, H, Nomura, H, Chiyoda, T, Hirasawa, A, Akahane, T, Nishio, H, Nishio, K & Aoki, D 2012, 'EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy', Genes Chromosomes and Cancer, vol. 51, no. 3, pp. 300-312. https://doi.org/10.1002/gcc.21916

TY - JOUR

T1 - EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy

AU - Kataoka, Fumio

AU - Tsuda, Hiroshi

AU - Arao, Tokuzo

AU - Nishimura, Sadako

AU - Tanaka, Hideo

AU - Nomura, Hiroyuki

AU - Chiyoda, Tatsuyuki

AU - Hirasawa, Akira

AU - Akahane, Tomoko

AU - Nishio, Hiroshi

AU - Nishio, Kazuto

AU - Aoki, Daisuke

PY - 2012/3

Y1 - 2012/3

N2 - Stromal components interact with cancer cells to promote growth and metastasis. The purpose of this study was to identify genes expressed in stroma, which could provide prognostic information in epithelial ovarian cancer (EOC). Seventy-four patients were included. We performed gene expression profiling and confirmed array data using RT-PCR and immunohistochemistry. By microarray analysis, 52 candidate genes associated with progression free survival (PFS) were identified (P < 0.005). Expression of the early growth response 1 (EGR1) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) genes was further analyzed. Array data were confirmed by RT-PCR and multivariate analysis demonstrated that both EGR1 and FOSB expression in cancer stroma, and EGR1 expression in cancer are independent prognostic factors in EOC. Immunohistochemically, EGR1 protein is localized in cancer cells and α-smooth muscle actin positive stromal fibroblasts. The EGR1 and FOSB expression in stromal cells and EGR1 expression in cancer cells are prognostic indicators in EOC.

AB - Stromal components interact with cancer cells to promote growth and metastasis. The purpose of this study was to identify genes expressed in stroma, which could provide prognostic information in epithelial ovarian cancer (EOC). Seventy-four patients were included. We performed gene expression profiling and confirmed array data using RT-PCR and immunohistochemistry. By microarray analysis, 52 candidate genes associated with progression free survival (PFS) were identified (P < 0.005). Expression of the early growth response 1 (EGR1) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) genes was further analyzed. Array data were confirmed by RT-PCR and multivariate analysis demonstrated that both EGR1 and FOSB expression in cancer stroma, and EGR1 expression in cancer are independent prognostic factors in EOC. Immunohistochemically, EGR1 protein is localized in cancer cells and α-smooth muscle actin positive stromal fibroblasts. The EGR1 and FOSB expression in stromal cells and EGR1 expression in cancer cells are prognostic indicators in EOC.

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EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy

Abstract

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