Electrocardiographic Diagnosis of Hypertrophic Cardiomyopathy in the Pre- And Post-Diagnostic Phases in Children and Adolescents

Masao Yoshinaga; Hitoshi Horigome; Mamoru Ayusawa; Kazushi Yasuda; Shigetoyo Kogaki; Shozaburo Doi; Sigeru Tateno; Kunio Ohta; Tatsunori Hokosaki; Eiki Nishihara; Mari Iwamoto; Naokata Sumitomo; Hiroya Ushinohama; Naomi Izumida; Nobuo Tauchi; Yoshiaki Kato; Taichi Kato; Toshiyuki Chisaka; Takashi Higaki; Tatsuya Yoneyama; Katsumi Abe; Yoshihiro Nozaki; Akiko Komori; Satoru Kawai; Yumiko Ninomiya; Yuji Tanaka; Norihito Nuruki; Masahiro Sonoda; Kentaro Ueno; Daisuke Hazeki; Yuichi Nomura; Seiichi Sato; Keiichi Hirono; Susumu Hosokawa; Fumie Takechi; Yuichi Ishikawa; Tadayoshi Hata; Fukiko Ichida; Seiko Ohno; Naomasa Makita; Minoru Horie; Shouji Matsushima; Hiroyuki Tsutsui; Hiromitsu Ogata; Hideto Takahashi; Masami Nagashima

doi:10.1253/circj.CJ-21-0376

Electrocardiographic Diagnosis of Hypertrophic Cardiomyopathy in the Pre- And Post-Diagnostic Phases in Children and Adolescents

Masao Yoshinaga, Hitoshi Horigome, Mamoru Ayusawa, Kazushi Yasuda, Shigetoyo Kogaki, Shozaburo Doi, Sigeru Tateno, Kunio Ohta, Tatsunori Hokosaki, Eiki Nishihara, Mari Iwamoto, Naokata Sumitomo, Hiroya Ushinohama, Naomi Izumida, Nobuo Tauchi, Yoshiaki Kato, Taichi Kato, Toshiyuki Chisaka, Takashi Higaki, Tatsuya YoneyamaKatsumi Abe, Yoshihiro Nozaki, Akiko Komori, Satoru Kawai, Yumiko Ninomiya, Yuji Tanaka, Norihito Nuruki, Masahiro Sonoda, Kentaro Ueno, Daisuke Hazeki, Yuichi Nomura, Seiichi Sato, Keiichi Hirono, Susumu Hosokawa, Fumie Takechi, Yuichi Ishikawa, Tadayoshi Hata, Fukiko Ichida, Seiko Ohno, Naomasa Makita, Minoru Horie, Shouji Matsushima, Hiroyuki Tsutsui, Hiromitsu Ogata, Hideto Takahashi, Masami Nagashima

Clinical Laboratory

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background: The usefulness of electrocardiographic (ECG) voltage criteria for diagnosing hypertrophic cardiomyopathy (HCM) in pediatric patients is poorly defined. Methods and Results: ECGs at the 1st grade (mean [±SD] age 6.6±0.3 years) were available for 11 patients diagnosed with HCM at around the 7th grade (13.2±0.3 years). ECGs were available for another 64 patients diagnosed with HCM in the 1st (n=15), 7th (n=32), and 10th (n=17) grades. Fifty-one voltage criteria were developed by grade and sex using 62,841 ECGs from the general population. Voltage criteria were set at the 99.95th percentile (1/2,000) point based on the estimated prevalence of childhood HCM (2.9 per 100,000 [1/34,483]) to decrease false negatives. Conventional criteria were from guidelines for school-aged children in Japan. Of 11 patients before diagnosis, 2 satisfied conventional criteria in 1st grade; 5 (56%) of the remaining 9 patients fulfilled 2 voltage criteria (R wave in limb-lead I [RI]+S wave in lead V3 [SV3] and R wave in lead V3 [RV3]+SV3). Robustness analysis for sensitivity showed RV3+SV3 was superior to RI+SV3. For all patients after diagnosis, RI+SV4 was the main candidate. However, conventional criteria were more useful than voltage criteria. Conclusions: Early HCM prediction was possible using RV3+SV3 in >50% of patients in 1st grade. Voltage criteria may help diagnose prediagnostic or early HCM, and prevent tragic accidents, although further prospective studies are required.

Original language	English
Pages (from-to)	118-127
Number of pages	10
Journal	Circulation Journal
Volume	86
Issue number	1
DOIs	https://doi.org/10.1253/circj.CJ-21-0376
Publication status	Published - 2022

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

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10.1253/circj.CJ-21-0376

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Yoshinaga, M., Horigome, H., Ayusawa, M., Yasuda, K., Kogaki, S., Doi, S., Tateno, S., Ohta, K., Hokosaki, T., Nishihara, E., Iwamoto, M., Sumitomo, N., Ushinohama, H., Izumida, N., Tauchi, N., Kato, Y., Kato, T., Chisaka, T., Higaki, T., ... Nagashima, M. (2022). Electrocardiographic Diagnosis of Hypertrophic Cardiomyopathy in the Pre- And Post-Diagnostic Phases in Children and Adolescents. Circulation Journal, 86(1), 118-127. https://doi.org/10.1253/circj.CJ-21-0376

@article{b90a2415530349529780c8cc2bfdd1ac,

title = "Electrocardiographic Diagnosis of Hypertrophic Cardiomyopathy in the Pre- And Post-Diagnostic Phases in Children and Adolescents",

abstract = "Background: The usefulness of electrocardiographic (ECG) voltage criteria for diagnosing hypertrophic cardiomyopathy (HCM) in pediatric patients is poorly defined. Methods and Results: ECGs at the 1st grade (mean [±SD] age 6.6±0.3 years) were available for 11 patients diagnosed with HCM at around the 7th grade (13.2±0.3 years). ECGs were available for another 64 patients diagnosed with HCM in the 1st (n=15), 7th (n=32), and 10th (n=17) grades. Fifty-one voltage criteria were developed by grade and sex using 62,841 ECGs from the general population. Voltage criteria were set at the 99.95th percentile (1/2,000) point based on the estimated prevalence of childhood HCM (2.9 per 100,000 [1/34,483]) to decrease false negatives. Conventional criteria were from guidelines for school-aged children in Japan. Of 11 patients before diagnosis, 2 satisfied conventional criteria in 1st grade; 5 (56%) of the remaining 9 patients fulfilled 2 voltage criteria (R wave in limb-lead I [RI]+S wave in lead V3 [SV3] and R wave in lead V3 [RV3]+SV3). Robustness analysis for sensitivity showed RV3+SV3 was superior to RI+SV3. For all patients after diagnosis, RI+SV4 was the main candidate. However, conventional criteria were more useful than voltage criteria. Conclusions: Early HCM prediction was possible using RV3+SV3 in >50% of patients in 1st grade. Voltage criteria may help diagnose prediagnostic or early HCM, and prevent tragic accidents, although further prospective studies are required.",

keywords = "Children, Diagnosis, Electrocardiography, Hypertrophic cardiomyopathy, Prevention",

author = "Masao Yoshinaga and Hitoshi Horigome and Mamoru Ayusawa and Kazushi Yasuda and Shigetoyo Kogaki and Shozaburo Doi and Sigeru Tateno and Kunio Ohta and Tatsunori Hokosaki and Eiki Nishihara and Mari Iwamoto and Naokata Sumitomo and Hiroya Ushinohama and Naomi Izumida and Nobuo Tauchi and Yoshiaki Kato and Taichi Kato and Toshiyuki Chisaka and Takashi Higaki and Tatsuya Yoneyama and Katsumi Abe and Yoshihiro Nozaki and Akiko Komori and Satoru Kawai and Yumiko Ninomiya and Yuji Tanaka and Norihito Nuruki and Masahiro Sonoda and Kentaro Ueno and Daisuke Hazeki and Yuichi Nomura and Seiichi Sato and Keiichi Hirono and Susumu Hosokawa and Fumie Takechi and Yuichi Ishikawa and Tadayoshi Hata and Fukiko Ichida and Seiko Ohno and Naomasa Makita and Minoru Horie and Shouji Matsushima and Hiroyuki Tsutsui and Hiromitsu Ogata and Hideto Takahashi and Masami Nagashima",

year = "2022",

doi = "10.1253/circj.CJ-21-0376",

language = "English",

volume = "86",

pages = "118--127",

journal = "Circulation Journal",

issn = "1346-9843",

publisher = "Japanese Circulation Society",

number = "1",

}

Yoshinaga, M, Horigome, H, Ayusawa, M, Yasuda, K, Kogaki, S, Doi, S, Tateno, S, Ohta, K, Hokosaki, T, Nishihara, E, Iwamoto, M, Sumitomo, N, Ushinohama, H, Izumida, N, Tauchi, N, Kato, Y, Kato, T, Chisaka, T, Higaki, T, Yoneyama, T, Abe, K, Nozaki, Y, Komori, A, Kawai, S, Ninomiya, Y, Tanaka, Y, Nuruki, N, Sonoda, M, Ueno, K, Hazeki, D, Nomura, Y, Sato, S, Hirono, K, Hosokawa, S, Takechi, F, Ishikawa, Y, Hata, T, Ichida, F, Ohno, S, Makita, N, Horie, M, Matsushima, S, Tsutsui, H, Ogata, H, Takahashi, H & Nagashima, M 2022, 'Electrocardiographic Diagnosis of Hypertrophic Cardiomyopathy in the Pre- And Post-Diagnostic Phases in Children and Adolescents', Circulation Journal, vol. 86, no. 1, pp. 118-127. https://doi.org/10.1253/circj.CJ-21-0376

TY - JOUR

T1 - Electrocardiographic Diagnosis of Hypertrophic Cardiomyopathy in the Pre- And Post-Diagnostic Phases in Children and Adolescents

AU - Yoshinaga, Masao

AU - Horigome, Hitoshi

AU - Ayusawa, Mamoru

AU - Yasuda, Kazushi

AU - Kogaki, Shigetoyo

AU - Doi, Shozaburo

AU - Tateno, Sigeru

AU - Ohta, Kunio

AU - Hokosaki, Tatsunori

AU - Nishihara, Eiki

AU - Iwamoto, Mari

AU - Sumitomo, Naokata

AU - Ushinohama, Hiroya

AU - Izumida, Naomi

AU - Tauchi, Nobuo

AU - Kato, Yoshiaki

AU - Kato, Taichi

AU - Chisaka, Toshiyuki

AU - Higaki, Takashi

AU - Yoneyama, Tatsuya

AU - Abe, Katsumi

AU - Nozaki, Yoshihiro

AU - Komori, Akiko

AU - Kawai, Satoru

AU - Ninomiya, Yumiko

AU - Tanaka, Yuji

AU - Nuruki, Norihito

AU - Sonoda, Masahiro

AU - Ueno, Kentaro

AU - Hazeki, Daisuke

AU - Nomura, Yuichi

AU - Sato, Seiichi

AU - Hirono, Keiichi

AU - Hosokawa, Susumu

AU - Takechi, Fumie

AU - Ishikawa, Yuichi

AU - Hata, Tadayoshi

AU - Ichida, Fukiko

AU - Ohno, Seiko

AU - Makita, Naomasa

AU - Horie, Minoru

AU - Matsushima, Shouji

AU - Tsutsui, Hiroyuki

AU - Ogata, Hiromitsu

AU - Takahashi, Hideto

AU - Nagashima, Masami

PY - 2022

Y1 - 2022

N2 - Background: The usefulness of electrocardiographic (ECG) voltage criteria for diagnosing hypertrophic cardiomyopathy (HCM) in pediatric patients is poorly defined. Methods and Results: ECGs at the 1st grade (mean [±SD] age 6.6±0.3 years) were available for 11 patients diagnosed with HCM at around the 7th grade (13.2±0.3 years). ECGs were available for another 64 patients diagnosed with HCM in the 1st (n=15), 7th (n=32), and 10th (n=17) grades. Fifty-one voltage criteria were developed by grade and sex using 62,841 ECGs from the general population. Voltage criteria were set at the 99.95th percentile (1/2,000) point based on the estimated prevalence of childhood HCM (2.9 per 100,000 [1/34,483]) to decrease false negatives. Conventional criteria were from guidelines for school-aged children in Japan. Of 11 patients before diagnosis, 2 satisfied conventional criteria in 1st grade; 5 (56%) of the remaining 9 patients fulfilled 2 voltage criteria (R wave in limb-lead I [RI]+S wave in lead V3 [SV3] and R wave in lead V3 [RV3]+SV3). Robustness analysis for sensitivity showed RV3+SV3 was superior to RI+SV3. For all patients after diagnosis, RI+SV4 was the main candidate. However, conventional criteria were more useful than voltage criteria. Conclusions: Early HCM prediction was possible using RV3+SV3 in >50% of patients in 1st grade. Voltage criteria may help diagnose prediagnostic or early HCM, and prevent tragic accidents, although further prospective studies are required.

AB - Background: The usefulness of electrocardiographic (ECG) voltage criteria for diagnosing hypertrophic cardiomyopathy (HCM) in pediatric patients is poorly defined. Methods and Results: ECGs at the 1st grade (mean [±SD] age 6.6±0.3 years) were available for 11 patients diagnosed with HCM at around the 7th grade (13.2±0.3 years). ECGs were available for another 64 patients diagnosed with HCM in the 1st (n=15), 7th (n=32), and 10th (n=17) grades. Fifty-one voltage criteria were developed by grade and sex using 62,841 ECGs from the general population. Voltage criteria were set at the 99.95th percentile (1/2,000) point based on the estimated prevalence of childhood HCM (2.9 per 100,000 [1/34,483]) to decrease false negatives. Conventional criteria were from guidelines for school-aged children in Japan. Of 11 patients before diagnosis, 2 satisfied conventional criteria in 1st grade; 5 (56%) of the remaining 9 patients fulfilled 2 voltage criteria (R wave in limb-lead I [RI]+S wave in lead V3 [SV3] and R wave in lead V3 [RV3]+SV3). Robustness analysis for sensitivity showed RV3+SV3 was superior to RI+SV3. For all patients after diagnosis, RI+SV4 was the main candidate. However, conventional criteria were more useful than voltage criteria. Conclusions: Early HCM prediction was possible using RV3+SV3 in >50% of patients in 1st grade. Voltage criteria may help diagnose prediagnostic or early HCM, and prevent tragic accidents, although further prospective studies are required.

KW - Children

KW - Diagnosis

KW - Electrocardiography

KW - Hypertrophic cardiomyopathy

KW - Prevention

UR - http://www.scopus.com/inward/record.url?scp=85122177848&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85122177848&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-21-0376

DO - 10.1253/circj.CJ-21-0376

M3 - Article

C2 - 34615813

AN - SCOPUS:85122177848

SN - 1346-9843

VL - 86

SP - 118

EP - 127

JO - Circulation Journal

JF - Circulation Journal

IS - 1

ER -

Electrocardiographic Diagnosis of Hypertrophic Cardiomyopathy in the Pre- And Post-Diagnostic Phases in Children and Adolescents

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