Elevated aldosterone in amniotic fluid and maternal blood has diagnostic potential in pregnancies complicated with a fetus of bartter syndrome

Tamao Nakanishi, Nobuhiro Suzumori, Haruo Mizuno, Kazutaka Suzuki, Takeshi Sato, Mitsuyo Tanemura, Yoshikatsu Suzuki, Kaoru Suzumori

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Pregnancies with fetuses affected with the Bartter syndrome, an autosomal recessive disorder of hyperreninism and hyperaldosteronism, are complicated by early onset of polyhydramnios which results in preterm deliveries. We have assessed biochemical changes in amniotic fluid and the mother's blood with a view to early diagnosis. Aldosterone levels of both amniotic fluid and the mother's blood were found to be increased at 27 weeks of gestation, while electrolyte levels did not differ significantly from those reported earlier for controls. After birth the baby suffered from polyuria with hyponatremia, hypomagnesemia and hypercalciuria which could be controlled by treatment with sodium chloride and magnesium. Elevated aldosterone thus might be a useful marker for early diagnostic purposes.

Original languageEnglish
Pages (from-to)481-484
Number of pages4
JournalFetal Diagnosis and Therapy
Volume20
Issue number6
DOIs
Publication statusPublished - 11-2005

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynaecology

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