TY - JOUR
T1 - Elevated platelet count as predictor of recurrence in rectal cancer patients undergoing preoperative chemoradiotherapy followed by surgery
AU - Toiyama, Yuji
AU - Inoue, Yasuhiro
AU - Kawamura, Mikio
AU - Kawamoto, Aya
AU - Okugawa, Yoshinaga
AU - Hiro, Jyunichiro
AU - Saigusa, Susumu
AU - Tanaka, Koji
AU - Mohri, Yasuhiko
AU - Kusunoki, Masato
PY - 2015/2
Y1 - 2015/2
N2 - The impact of systemic inflammatory response (SIR) on prognostic and predictive outcome in rectal cancer after neoadjuvant chemoradiotherapy (CRT) has not been fully investigated. This retrospective study enrolled 89 patients with locally advanced rectal cancer who underwent neoadjuvant CRT and for whom platelet (PLT) counts and SIR status [neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR)] were available. Both clinical values of PLT and SIR status in rectal cancer patients were investigated. Elevated PLT, NLR, PLR, and pathologic TNM stage III [ypN(+)] were associated with significantly poor overall survival (OS). Elevated PLT, NLR, and ypN(+) were shown to independently predict OS. Elevated PLT and ypN(+) significantly predicted poor disease-free survival (DFS). Elevated PLT was identified as the only independent predictor of DFS. PLT counts are a promising pre-CRT biomarker for predicting recurrence and poor prognosis in rectal cancer.
AB - The impact of systemic inflammatory response (SIR) on prognostic and predictive outcome in rectal cancer after neoadjuvant chemoradiotherapy (CRT) has not been fully investigated. This retrospective study enrolled 89 patients with locally advanced rectal cancer who underwent neoadjuvant CRT and for whom platelet (PLT) counts and SIR status [neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR)] were available. Both clinical values of PLT and SIR status in rectal cancer patients were investigated. Elevated PLT, NLR, PLR, and pathologic TNM stage III [ypN(+)] were associated with significantly poor overall survival (OS). Elevated PLT, NLR, and ypN(+) were shown to independently predict OS. Elevated PLT and ypN(+) significantly predicted poor disease-free survival (DFS). Elevated PLT was identified as the only independent predictor of DFS. PLT counts are a promising pre-CRT biomarker for predicting recurrence and poor prognosis in rectal cancer.
UR - http://www.scopus.com/inward/record.url?scp=84974577765&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84974577765&partnerID=8YFLogxK
U2 - 10.9738/INTSURG-D-13-00178.1
DO - 10.9738/INTSURG-D-13-00178.1
M3 - Article
C2 - 25692418
AN - SCOPUS:84974577765
SN - 0020-8868
VL - 100
SP - 199
EP - 207
JO - International Surgery
JF - International Surgery
IS - 2
ER -