Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis: Association with pulmonary fibrosis

Toshihide Hara, Fumihide Ogawa, Koichi Yanaba, Yohei Iwata, Eiji Muroi, Kazuhiro Komura, Motoi Takenaka, Kazuhiro Shimizu, Minoru Hasegawa, Manabu Fujimoto, Shinichi Sato

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Abstract

Objective. To determine the serum concentrations and clinical association of polymorphonuclear neutrophilic leukocyte (PMN) elastase in patients with systemic sclerosis (SSc). Methods. Serum PMN elastase levels from 21 patients with limited cutaneous SSc (lSSc) and 32 with diffuse cutaneous SSc (dSSc) were examined by ELISA. Results. Serum PMN elastase levels were elevated in patients with SSc, especially dSSc, compared to healthy controls. SSc patients with elevated serum PMN elastase levels had more frequent presence of pulmonary fibrosis, arthritis, contracture of phalanges, and diffuse pigmentation. Anticentromere antibody was detected less frequently in SSc patients with elevated serum PMN elastase levels than in controls. Consistently, serum PMN elastase levels also correlated positively with serum levels of KL-6 and surfactant protein-D, serological markers for pulmonary fibrosis. Serum PMN elastase levels were also associated with levels of serum 8-isoprostane, an oxidative stress marker in SSc. Conclusion. Serum PMN elastase levels were elevated in patients with SSc, and it was more prominent in patients with pulmonary fibrosis, suggesting that serum PMN elastase is a novel serological marker for SSc-related pulmonary fibrosis. The Journal of Rheumatology

Original languageEnglish
Pages (from-to)99-105
Number of pages7
JournalJournal of Rheumatology
Volume36
Issue number1
DOIs
Publication statusPublished - 01-2009

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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    Hara, T., Ogawa, F., Yanaba, K., Iwata, Y., Muroi, E., Komura, K., Takenaka, M., Shimizu, K., Hasegawa, M., Fujimoto, M., & Sato, S. (2009). Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis: Association with pulmonary fibrosis. Journal of Rheumatology, 36(1), 99-105. https://doi.org/10.3899/jrheum.080269