TY - JOUR
T1 - Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis
T2 - Association with pulmonary fibrosis
AU - Hara, Toshihide
AU - Ogawa, Fumihide
AU - Yanaba, Koichi
AU - Iwata, Yohei
AU - Muroi, Eiji
AU - Komura, Kazuhiro
AU - Takenaka, Motoi
AU - Shimizu, Kazuhiro
AU - Hasegawa, Minoru
AU - Fujimoto, Manabu
AU - Sato, Shinichi
PY - 2009/1
Y1 - 2009/1
N2 - Objective. To determine the serum concentrations and clinical association of polymorphonuclear neutrophilic leukocyte (PMN) elastase in patients with systemic sclerosis (SSc). Methods. Serum PMN elastase levels from 21 patients with limited cutaneous SSc (lSSc) and 32 with diffuse cutaneous SSc (dSSc) were examined by ELISA. Results. Serum PMN elastase levels were elevated in patients with SSc, especially dSSc, compared to healthy controls. SSc patients with elevated serum PMN elastase levels had more frequent presence of pulmonary fibrosis, arthritis, contracture of phalanges, and diffuse pigmentation. Anticentromere antibody was detected less frequently in SSc patients with elevated serum PMN elastase levels than in controls. Consistently, serum PMN elastase levels also correlated positively with serum levels of KL-6 and surfactant protein-D, serological markers for pulmonary fibrosis. Serum PMN elastase levels were also associated with levels of serum 8-isoprostane, an oxidative stress marker in SSc. Conclusion. Serum PMN elastase levels were elevated in patients with SSc, and it was more prominent in patients with pulmonary fibrosis, suggesting that serum PMN elastase is a novel serological marker for SSc-related pulmonary fibrosis. The Journal of Rheumatology
AB - Objective. To determine the serum concentrations and clinical association of polymorphonuclear neutrophilic leukocyte (PMN) elastase in patients with systemic sclerosis (SSc). Methods. Serum PMN elastase levels from 21 patients with limited cutaneous SSc (lSSc) and 32 with diffuse cutaneous SSc (dSSc) were examined by ELISA. Results. Serum PMN elastase levels were elevated in patients with SSc, especially dSSc, compared to healthy controls. SSc patients with elevated serum PMN elastase levels had more frequent presence of pulmonary fibrosis, arthritis, contracture of phalanges, and diffuse pigmentation. Anticentromere antibody was detected less frequently in SSc patients with elevated serum PMN elastase levels than in controls. Consistently, serum PMN elastase levels also correlated positively with serum levels of KL-6 and surfactant protein-D, serological markers for pulmonary fibrosis. Serum PMN elastase levels were also associated with levels of serum 8-isoprostane, an oxidative stress marker in SSc. Conclusion. Serum PMN elastase levels were elevated in patients with SSc, and it was more prominent in patients with pulmonary fibrosis, suggesting that serum PMN elastase is a novel serological marker for SSc-related pulmonary fibrosis. The Journal of Rheumatology
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U2 - 10.3899/jrheum.080269
DO - 10.3899/jrheum.080269
M3 - Article
C2 - 19208531
AN - SCOPUS:58149517584
SN - 0315-162X
VL - 36
SP - 99
EP - 105
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 1
ER -