Elevated serum cytokine levels are associated with human herpesvirus 6 reactivation in hematopoietic stem cell transplantation recipients

Ayano Fujita, Masaru Ihira, Ryota Suzuki, Yoshihiko Enomoto, Hiroko Sugiyama, Ken Sugata, Sadao Suga, Yoshizo Asano, Hiroshi Yagasaki, Seiji Kojima, Kimikazu Matsumoto, Koji Kato, Tetsushi Yoshikawa

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Although it has been demonstrated that human herpesvirus 6 (HHV-6) reactivation generally occurs approximately 2-3 weeks after transplantation in the hematopoietic stem cell transplantation (HSCT) recipients, the mechanism of viral reactivation remains unclear. To explore the relationship between HHV-6 reactivation and plasma cytokine levels, 24 HSCT recipients underwent measurements of plasma proinflammatory cytokine levels (IL-6, TNF-α, IL-1β, and IFN-γ), viral isolation, and serological assays. Of these patients, 14 developed an HHV-6 reactivation, and 9 developed HHV-6 viremia approximately 2-3 weeks after transplantation. IL-6 levels were significantly higher in the recipients with an HHV-6 reactivation than in the subjects without an HHV-6 reactivation at 1 week, 2 weeks, and 4 weeks after transplantation. In addition, the level of TNF-α was significantly higher in recipients with an HHV-6 reactivation than in those without an HHV-6 reactivation at 2 weeks post-transplantation. Low levels of IL-1β and IFN-γ were detected in a small number of the plasma samples, although there were no significant differences between the two groups in the levels of these cytokines. These results imply that proinflammatory cytokines, in particular IL-6 and TNF-α, play a role in the pathogenesis of HHV-6 reactivation after HSCT.

Original languageEnglish
Pages (from-to)241-248
Number of pages8
JournalJournal of Infection
Volume57
Issue number3
DOIs
Publication statusPublished - 01-09-2008

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Human Herpesvirus 6
Hematopoietic Stem Cell Transplantation
Cytokines
Serum
Transplantation
Interleukin-6
Interleukin-1
Viremia

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Fujita, Ayano ; Ihira, Masaru ; Suzuki, Ryota ; Enomoto, Yoshihiko ; Sugiyama, Hiroko ; Sugata, Ken ; Suga, Sadao ; Asano, Yoshizo ; Yagasaki, Hiroshi ; Kojima, Seiji ; Matsumoto, Kimikazu ; Kato, Koji ; Yoshikawa, Tetsushi. / Elevated serum cytokine levels are associated with human herpesvirus 6 reactivation in hematopoietic stem cell transplantation recipients. In: Journal of Infection. 2008 ; Vol. 57, No. 3. pp. 241-248.
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abstract = "Although it has been demonstrated that human herpesvirus 6 (HHV-6) reactivation generally occurs approximately 2-3 weeks after transplantation in the hematopoietic stem cell transplantation (HSCT) recipients, the mechanism of viral reactivation remains unclear. To explore the relationship between HHV-6 reactivation and plasma cytokine levels, 24 HSCT recipients underwent measurements of plasma proinflammatory cytokine levels (IL-6, TNF-α, IL-1β, and IFN-γ), viral isolation, and serological assays. Of these patients, 14 developed an HHV-6 reactivation, and 9 developed HHV-6 viremia approximately 2-3 weeks after transplantation. IL-6 levels were significantly higher in the recipients with an HHV-6 reactivation than in the subjects without an HHV-6 reactivation at 1 week, 2 weeks, and 4 weeks after transplantation. In addition, the level of TNF-α was significantly higher in recipients with an HHV-6 reactivation than in those without an HHV-6 reactivation at 2 weeks post-transplantation. Low levels of IL-1β and IFN-γ were detected in a small number of the plasma samples, although there were no significant differences between the two groups in the levels of these cytokines. These results imply that proinflammatory cytokines, in particular IL-6 and TNF-α, play a role in the pathogenesis of HHV-6 reactivation after HSCT.",
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Fujita, A, Ihira, M, Suzuki, R, Enomoto, Y, Sugiyama, H, Sugata, K, Suga, S, Asano, Y, Yagasaki, H, Kojima, S, Matsumoto, K, Kato, K & Yoshikawa, T 2008, 'Elevated serum cytokine levels are associated with human herpesvirus 6 reactivation in hematopoietic stem cell transplantation recipients', Journal of Infection, vol. 57, no. 3, pp. 241-248. https://doi.org/10.1016/j.jinf.2008.06.014

Elevated serum cytokine levels are associated with human herpesvirus 6 reactivation in hematopoietic stem cell transplantation recipients. / Fujita, Ayano; Ihira, Masaru; Suzuki, Ryota; Enomoto, Yoshihiko; Sugiyama, Hiroko; Sugata, Ken; Suga, Sadao; Asano, Yoshizo; Yagasaki, Hiroshi; Kojima, Seiji; Matsumoto, Kimikazu; Kato, Koji; Yoshikawa, Tetsushi.

In: Journal of Infection, Vol. 57, No. 3, 01.09.2008, p. 241-248.

Research output: Contribution to journalArticle

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T1 - Elevated serum cytokine levels are associated with human herpesvirus 6 reactivation in hematopoietic stem cell transplantation recipients

AU - Fujita, Ayano

AU - Ihira, Masaru

AU - Suzuki, Ryota

AU - Enomoto, Yoshihiko

AU - Sugiyama, Hiroko

AU - Sugata, Ken

AU - Suga, Sadao

AU - Asano, Yoshizo

AU - Yagasaki, Hiroshi

AU - Kojima, Seiji

AU - Matsumoto, Kimikazu

AU - Kato, Koji

AU - Yoshikawa, Tetsushi

PY - 2008/9/1

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N2 - Although it has been demonstrated that human herpesvirus 6 (HHV-6) reactivation generally occurs approximately 2-3 weeks after transplantation in the hematopoietic stem cell transplantation (HSCT) recipients, the mechanism of viral reactivation remains unclear. To explore the relationship between HHV-6 reactivation and plasma cytokine levels, 24 HSCT recipients underwent measurements of plasma proinflammatory cytokine levels (IL-6, TNF-α, IL-1β, and IFN-γ), viral isolation, and serological assays. Of these patients, 14 developed an HHV-6 reactivation, and 9 developed HHV-6 viremia approximately 2-3 weeks after transplantation. IL-6 levels were significantly higher in the recipients with an HHV-6 reactivation than in the subjects without an HHV-6 reactivation at 1 week, 2 weeks, and 4 weeks after transplantation. In addition, the level of TNF-α was significantly higher in recipients with an HHV-6 reactivation than in those without an HHV-6 reactivation at 2 weeks post-transplantation. Low levels of IL-1β and IFN-γ were detected in a small number of the plasma samples, although there were no significant differences between the two groups in the levels of these cytokines. These results imply that proinflammatory cytokines, in particular IL-6 and TNF-α, play a role in the pathogenesis of HHV-6 reactivation after HSCT.

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