TY - JOUR
T1 - Elevated serum cytokine levels are associated with human herpesvirus 6 reactivation in hematopoietic stem cell transplantation recipients
AU - Fujita, Ayano
AU - Ihira, Masaru
AU - Suzuki, Ryota
AU - Enomoto, Yoshihiko
AU - Sugiyama, Hiroko
AU - Sugata, Ken
AU - Suga, Sadao
AU - Asano, Yoshizo
AU - Yagasaki, Hiroshi
AU - Kojima, Seiji
AU - Matsumoto, Kimikazu
AU - Kato, Koji
AU - Yoshikawa, Tetsushi
N1 - Funding Information:
Financial supports. This work was supported in part by a grant-in-aid for the 21st Century COE Program of Medicine and the Open Research Center, both at Fujita Health University, from the Ministry of Education, Culture, Sports, Science and Technology of Japan. This study was also conducted with the support of a grant for Research Promotion of Emerging and Re-emerging Infectious Diseases (H18 – Shinko-013) from Ministry of Health, Labour and Welfare of Japan.
PY - 2008/9
Y1 - 2008/9
N2 - Although it has been demonstrated that human herpesvirus 6 (HHV-6) reactivation generally occurs approximately 2-3 weeks after transplantation in the hematopoietic stem cell transplantation (HSCT) recipients, the mechanism of viral reactivation remains unclear. To explore the relationship between HHV-6 reactivation and plasma cytokine levels, 24 HSCT recipients underwent measurements of plasma proinflammatory cytokine levels (IL-6, TNF-α, IL-1β, and IFN-γ), viral isolation, and serological assays. Of these patients, 14 developed an HHV-6 reactivation, and 9 developed HHV-6 viremia approximately 2-3 weeks after transplantation. IL-6 levels were significantly higher in the recipients with an HHV-6 reactivation than in the subjects without an HHV-6 reactivation at 1 week, 2 weeks, and 4 weeks after transplantation. In addition, the level of TNF-α was significantly higher in recipients with an HHV-6 reactivation than in those without an HHV-6 reactivation at 2 weeks post-transplantation. Low levels of IL-1β and IFN-γ were detected in a small number of the plasma samples, although there were no significant differences between the two groups in the levels of these cytokines. These results imply that proinflammatory cytokines, in particular IL-6 and TNF-α, play a role in the pathogenesis of HHV-6 reactivation after HSCT.
AB - Although it has been demonstrated that human herpesvirus 6 (HHV-6) reactivation generally occurs approximately 2-3 weeks after transplantation in the hematopoietic stem cell transplantation (HSCT) recipients, the mechanism of viral reactivation remains unclear. To explore the relationship between HHV-6 reactivation and plasma cytokine levels, 24 HSCT recipients underwent measurements of plasma proinflammatory cytokine levels (IL-6, TNF-α, IL-1β, and IFN-γ), viral isolation, and serological assays. Of these patients, 14 developed an HHV-6 reactivation, and 9 developed HHV-6 viremia approximately 2-3 weeks after transplantation. IL-6 levels were significantly higher in the recipients with an HHV-6 reactivation than in the subjects without an HHV-6 reactivation at 1 week, 2 weeks, and 4 weeks after transplantation. In addition, the level of TNF-α was significantly higher in recipients with an HHV-6 reactivation than in those without an HHV-6 reactivation at 2 weeks post-transplantation. Low levels of IL-1β and IFN-γ were detected in a small number of the plasma samples, although there were no significant differences between the two groups in the levels of these cytokines. These results imply that proinflammatory cytokines, in particular IL-6 and TNF-α, play a role in the pathogenesis of HHV-6 reactivation after HSCT.
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U2 - 10.1016/j.jinf.2008.06.014
DO - 10.1016/j.jinf.2008.06.014
M3 - Article
C2 - 18662831
AN - SCOPUS:50449084921
SN - 0163-4453
VL - 57
SP - 241
EP - 248
JO - Journal of Infection
JF - Journal of Infection
IS - 3
ER -
