TY - JOUR
T1 - Elevated steroid sulfatase expression in breast cancers
AU - Utsumi, Toshiaki
AU - Yoshimura, Noriko
AU - Takeuchi, Shinji
AU - Maruta, Morito
AU - Maeda, Kotaro
AU - Harada, Nobuhiro
N1 - Funding Information:
This work was supported in part by Grants-in-Aid for Medical Research from Fujita Memorial Fund and by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan.
PY - 2000/6/1
Y1 - 2000/6/1
N2 - In situ estrogen synthesis makes an important contribution to the high estrogen concentration found in breast cancer tissues. Steroid sulfatase which hydrolyzes several sulfated steroids such as estrone sulfate, dehydroepiandrosterone sulfate, and cholesterol sulfate may be involved. In the present study, we therefore, assessed steroid sulfatase mRNA levels in breast malignancies and background tissues from 38 patients by reverse transcription and polymerase chain reaction. The levels in breast cancer tissues were significantly increased at 1458.4±2119.7 attomoles/mg RNA (mean ± SD) as compared with 535.6±663.4 attomoles/mg RNA for non-malignant tissues (P<0.001). Thus, increased steroid sulfatase expression may be partly responsible for local overproduction of estrogen and provide a growth advantage for tumor cells. Copyright (C) 2000 Elsevier Science Ltd.
AB - In situ estrogen synthesis makes an important contribution to the high estrogen concentration found in breast cancer tissues. Steroid sulfatase which hydrolyzes several sulfated steroids such as estrone sulfate, dehydroepiandrosterone sulfate, and cholesterol sulfate may be involved. In the present study, we therefore, assessed steroid sulfatase mRNA levels in breast malignancies and background tissues from 38 patients by reverse transcription and polymerase chain reaction. The levels in breast cancer tissues were significantly increased at 1458.4±2119.7 attomoles/mg RNA (mean ± SD) as compared with 535.6±663.4 attomoles/mg RNA for non-malignant tissues (P<0.001). Thus, increased steroid sulfatase expression may be partly responsible for local overproduction of estrogen and provide a growth advantage for tumor cells. Copyright (C) 2000 Elsevier Science Ltd.
UR - http://www.scopus.com/inward/record.url?scp=0034210051&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034210051&partnerID=8YFLogxK
U2 - 10.1016/S0960-0760(00)00060-1
DO - 10.1016/S0960-0760(00)00060-1
M3 - Article
C2 - 10925213
AN - SCOPUS:0034210051
SN - 0960-0760
VL - 73
SP - 141
EP - 145
JO - Journal of Steroid Biochemistry and Molecular Biology
JF - Journal of Steroid Biochemistry and Molecular Biology
IS - 3-4
ER -
