TY - JOUR
T1 - Elevation of serum creatine kinase in response to medical treatment of Graves' disease in children
AU - Mizuno, Haruo
AU - Sugiyama, Yukari
AU - Nishi, Yoshikazu
AU - Ueda, Noriko
AU - Ohro, Yoichiro
AU - Togari, Hajime
PY - 2006/2
Y1 - 2006/2
N2 - We describe two cases of increases in serum creatine kinase (CK) concentrations in children undergoing treatment of Graves' disease with antithyroid medications. Presenting complaints consisted of myalgias and muscle cramping in both patients, and increases in serum CK levels were noted 1 mo after initiation of antithyroid drugs. Both patients were euthyroid at the time of CK elevation. While the mechanisms for this process are not clear, it is likely that the acute decrease of thyroid hormones in tissues following a state of chronic hyperthyroidism may result in relative hypothyroid states and subsequent alterations in CK concentrations. Conclusion: Although this side effect has been reported in adults, it is a novel finding in children. Clinicians should be aware of the rare potential for elevations in serum CK when initiating treatment for Graves' disease in children.
AB - We describe two cases of increases in serum creatine kinase (CK) concentrations in children undergoing treatment of Graves' disease with antithyroid medications. Presenting complaints consisted of myalgias and muscle cramping in both patients, and increases in serum CK levels were noted 1 mo after initiation of antithyroid drugs. Both patients were euthyroid at the time of CK elevation. While the mechanisms for this process are not clear, it is likely that the acute decrease of thyroid hormones in tissues following a state of chronic hyperthyroidism may result in relative hypothyroid states and subsequent alterations in CK concentrations. Conclusion: Although this side effect has been reported in adults, it is a novel finding in children. Clinicians should be aware of the rare potential for elevations in serum CK when initiating treatment for Graves' disease in children.
UR - http://www.scopus.com/inward/record.url?scp=31944437643&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=31944437643&partnerID=8YFLogxK
U2 - 10.1080/08035250500341444
DO - 10.1080/08035250500341444
M3 - Article
C2 - 16449033
AN - SCOPUS:31944437643
SN - 0803-5253
VL - 95
SP - 243
EP - 245
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
IS - 2
ER -