TY - JOUR
T1 - Elevation of serum cystatin C concentrations in patients with chronic liver disease
AU - Takeuchi, Mamiko
AU - Fukuda, Yoshihide
AU - Nakano, Isao
AU - Katano, Yoshiaki
AU - Hayakawa, Tetsuo
PY - 2001
Y1 - 2001
N2 - Objective We examined serum cystatin C concentrations in patients to explore the possible clinical application of cystatin C as a marker of disease severity in cases of chronic liver diseases. Methods Serum cystatin C concentrations were determined by an enzyme-linked immunosorbent assay kit in 103 patients with various chronic liver diseases and compared with concentrations in healthy control volunteers. Results The mean cystatin C concentration was 0.68 ± 0.03 mg/l in chronic hepatitis patients, 1.13 ± 0.09 mg/l in liver cirrhosis patients and 1.16 ± 0.10 mg/l in hepatocellular carcinoma patients, all significantly higher than concentrations in the control volunteers (P < 0.0001). Significant correlations were observed between cystatin C concentrations and total bilirubin levels, albumin levels, platelet levels, type IV collagen levels and hyaluronic acid levels. Serum cystatin C concentrations correlated well with histological stages despite the lack of correlation with histological grades. Conclusion Our results show that serum cystatin C increases with the progression of chronic liver disease and that it is a potential marker for liver fibrosis.
AB - Objective We examined serum cystatin C concentrations in patients to explore the possible clinical application of cystatin C as a marker of disease severity in cases of chronic liver diseases. Methods Serum cystatin C concentrations were determined by an enzyme-linked immunosorbent assay kit in 103 patients with various chronic liver diseases and compared with concentrations in healthy control volunteers. Results The mean cystatin C concentration was 0.68 ± 0.03 mg/l in chronic hepatitis patients, 1.13 ± 0.09 mg/l in liver cirrhosis patients and 1.16 ± 0.10 mg/l in hepatocellular carcinoma patients, all significantly higher than concentrations in the control volunteers (P < 0.0001). Significant correlations were observed between cystatin C concentrations and total bilirubin levels, albumin levels, platelet levels, type IV collagen levels and hyaluronic acid levels. Serum cystatin C concentrations correlated well with histological stages despite the lack of correlation with histological grades. Conclusion Our results show that serum cystatin C increases with the progression of chronic liver disease and that it is a potential marker for liver fibrosis.
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U2 - 10.1097/00042737-200108000-00013
DO - 10.1097/00042737-200108000-00013
M3 - Article
C2 - 11507361
AN - SCOPUS:0034742041
SN - 0954-691X
VL - 13
SP - 951
EP - 955
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
IS - 8
ER -
