TY - JOUR
T1 - Emphysema quantification on low-dose CT using percentage of low-attenuation volume and size distribution of low-attenuation lung regions
T2 - Effects of adaptive iterative dose reduction using 3D processing
AU - Nishio, Mizuho
AU - Matsumoto, Sumiaki
AU - Seki, Shinichiro
AU - Koyama, Hisanobu
AU - Ohno, Yoshiharu
AU - Fujisawa, Yasuko
AU - Sugihara, Naoki
AU - Yoshikawa, Takeshi
AU - Sugimura, Kazuro
N1 - Funding Information:
M. Nishio, S. Matsumoto, Y. Ohno, T. Yoshikawa, and K. Sugimura have received research grants from Toshiba Medical Systems Corporation . Y. Fujisawa and N. Sugihara are employees of Toshiba Medical Systems Corporation. S. Seki and H. Koyama have no conflict of interest.
Publisher Copyright:
© 2014 Elsevier Ireland Ltd. All rights reserved.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Purpose To evaluate the effects of adaptive iterative dose reduction using 3D processing (AIDR 3D) for quantification of two measures of emphysema: percentage of low-attenuation volume (LAV%) and size distribution of low-attenuation lung regions.Method and materials: Fifty-two patients who underwent standard-dose (SDCT) and low-dose CT (LDCT) were included. SDCT without AIDR 3D, LDCT without AIDR 3D, and LDCT with AIDR 3D were used for emphysema quantification. First, LAV% was computed at 10 thresholds from -990 to -900 HU. Next, at the same thresholds, linear regression on a log-log plot was used to compute the power law exponent (D) for the cumulative frequency-size distribution of low-attenuation lung regions. Bland-Altman analysis was used to assess whether AIDR 3D improved agreement between LDCT and SDCT for emphysema quantification of LAV% and D.Results The mean relative differences in LAV% between LDCT without AIDR 3D and SDCT were 3.73%-88.18% and between LDCT with AIDR 3D and SDCT were -6.61% to 0.406%. The mean relative differences in D between LDCT without AIDR 3D and SDCT were 8.22%-19.11% and between LDCT with AIDR 3D and SDCT were 1.82%-4.79%. AIDR 3D improved agreement between LDCT and SDCT at thresholds from -930 to -990 HU for LAV% and at all thresholds for D.Conclusion AIDR 3D improved the consistency between LDCT and SDCT for emphysema quantification of LAV% and D.
AB - Purpose To evaluate the effects of adaptive iterative dose reduction using 3D processing (AIDR 3D) for quantification of two measures of emphysema: percentage of low-attenuation volume (LAV%) and size distribution of low-attenuation lung regions.Method and materials: Fifty-two patients who underwent standard-dose (SDCT) and low-dose CT (LDCT) were included. SDCT without AIDR 3D, LDCT without AIDR 3D, and LDCT with AIDR 3D were used for emphysema quantification. First, LAV% was computed at 10 thresholds from -990 to -900 HU. Next, at the same thresholds, linear regression on a log-log plot was used to compute the power law exponent (D) for the cumulative frequency-size distribution of low-attenuation lung regions. Bland-Altman analysis was used to assess whether AIDR 3D improved agreement between LDCT and SDCT for emphysema quantification of LAV% and D.Results The mean relative differences in LAV% between LDCT without AIDR 3D and SDCT were 3.73%-88.18% and between LDCT with AIDR 3D and SDCT were -6.61% to 0.406%. The mean relative differences in D between LDCT without AIDR 3D and SDCT were 8.22%-19.11% and between LDCT with AIDR 3D and SDCT were 1.82%-4.79%. AIDR 3D improved agreement between LDCT and SDCT at thresholds from -930 to -990 HU for LAV% and at all thresholds for D.Conclusion AIDR 3D improved the consistency between LDCT and SDCT for emphysema quantification of LAV% and D.
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U2 - 10.1016/j.ejrad.2014.09.011
DO - 10.1016/j.ejrad.2014.09.011
M3 - Article
C2 - 25445899
AN - SCOPUS:84914118890
SN - 0720-048X
VL - 83
SP - 2268
EP - 2276
JO - European journal of radiology
JF - European journal of radiology
IS - 12
ER -