Encephalitogenic peptide (EP) in human cerebrovascular white matter lesions

Hidekazu Tomimoto, Ichiro Akiguchi, Akinori Matsuo, Kazuhiro Terai, Hideaki Wakita, Jun Kimura, P. L. McGeer, Herbert Budka

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

THE expression of encephalitogenic peptide (EP), a 68-86 amino acid sequence of guinea pig myelin basic protein (MBP), was investigated in autopsied brains with focal cerebral damage or with diffuse white matter (WM) lesions. EP immunoreactive fibers were distributed in parallel with fibers immunoreactive for amyloid protein precursor (APP), an indicator of WM damages. EP was expressed in the periphery of cerebral infarctions and hematoma in the acute and subacute stages, but was also distributed in diffuse WM lesions due to heterogeneous causes. These data indicate that EP epitopes are exposed specifically in ongoing WM damages, and that the destruction of myelin occurs sporadically in diffuse WM lesions of varying intensity.

Original languageEnglish
Pages (from-to)3727-3730
Number of pages4
JournalNeuroReport
Volume8
Issue number17
DOIs
Publication statusPublished - 01-01-1997

Fingerprint

Peptides
Myelin Basic Protein
Amyloid beta-Protein Precursor
Cerebral Infarction
Myelin Sheath
Hematoma
Epitopes
Amino Acid Sequence
Guinea Pigs
White Matter
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Tomimoto, H., Akiguchi, I., Matsuo, A., Terai, K., Wakita, H., Kimura, J., ... Budka, H. (1997). Encephalitogenic peptide (EP) in human cerebrovascular white matter lesions. NeuroReport, 8(17), 3727-3730. https://doi.org/10.1097/00001756-199712010-00014
Tomimoto, Hidekazu ; Akiguchi, Ichiro ; Matsuo, Akinori ; Terai, Kazuhiro ; Wakita, Hideaki ; Kimura, Jun ; McGeer, P. L. ; Budka, Herbert. / Encephalitogenic peptide (EP) in human cerebrovascular white matter lesions. In: NeuroReport. 1997 ; Vol. 8, No. 17. pp. 3727-3730.
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Tomimoto, H, Akiguchi, I, Matsuo, A, Terai, K, Wakita, H, Kimura, J, McGeer, PL & Budka, H 1997, 'Encephalitogenic peptide (EP) in human cerebrovascular white matter lesions', NeuroReport, vol. 8, no. 17, pp. 3727-3730. https://doi.org/10.1097/00001756-199712010-00014

Encephalitogenic peptide (EP) in human cerebrovascular white matter lesions. / Tomimoto, Hidekazu; Akiguchi, Ichiro; Matsuo, Akinori; Terai, Kazuhiro; Wakita, Hideaki; Kimura, Jun; McGeer, P. L.; Budka, Herbert.

In: NeuroReport, Vol. 8, No. 17, 01.01.1997, p. 3727-3730.

Research output: Contribution to journalArticle

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AU - Tomimoto, Hidekazu

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