Encephalitogenic peptide (EP) in human cerebrovascular white matter lesions

Hidekazu Tomimoto; Ichiro Akiguchi; Akinori Matsuo; Kazuhiro Terai; Hideaki Wakita; Jun Kimura; P. L. McGeer; Herbert Budka

doi:10.1097/00001756-199712010-00014

Encephalitogenic peptide (EP) in human cerebrovascular white matter lesions

Hidekazu Tomimoto, Ichiro Akiguchi, Akinori Matsuo, Kazuhiro Terai, Hideaki Wakita, Jun Kimura, P. L. McGeer, Herbert Budka

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

THE expression of encephalitogenic peptide (EP), a 68-86 amino acid sequence of guinea pig myelin basic protein (MBP), was investigated in autopsied brains with focal cerebral damage or with diffuse white matter (WM) lesions. EP immunoreactive fibers were distributed in parallel with fibers immunoreactive for amyloid protein precursor (APP), an indicator of WM damages. EP was expressed in the periphery of cerebral infarctions and hematoma in the acute and subacute stages, but was also distributed in diffuse WM lesions due to heterogeneous causes. These data indicate that EP epitopes are exposed specifically in ongoing WM damages, and that the destruction of myelin occurs sporadically in diffuse WM lesions of varying intensity.

Original language	English
Pages (from-to)	3727-3730
Number of pages	4
Journal	Neuroreport
Volume	8
Issue number	17
DOIs	https://doi.org/10.1097/00001756-199712010-00014
Publication status	Published - 1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1097/00001756-199712010-00014

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abstract = "THE expression of encephalitogenic peptide (EP), a 68-86 amino acid sequence of guinea pig myelin basic protein (MBP), was investigated in autopsied brains with focal cerebral damage or with diffuse white matter (WM) lesions. EP immunoreactive fibers were distributed in parallel with fibers immunoreactive for amyloid protein precursor (APP), an indicator of WM damages. EP was expressed in the periphery of cerebral infarctions and hematoma in the acute and subacute stages, but was also distributed in diffuse WM lesions due to heterogeneous causes. These data indicate that EP epitopes are exposed specifically in ongoing WM damages, and that the destruction of myelin occurs sporadically in diffuse WM lesions of varying intensity.",

author = "Hidekazu Tomimoto and Ichiro Akiguchi and Akinori Matsuo and Kazuhiro Terai and Hideaki Wakita and Jun Kimura and McGeer, {P. L.} and Herbert Budka",

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T1 - Encephalitogenic peptide (EP) in human cerebrovascular white matter lesions

AU - Tomimoto, Hidekazu

AU - Akiguchi, Ichiro

AU - Matsuo, Akinori

AU - Terai, Kazuhiro

AU - Wakita, Hideaki

AU - Kimura, Jun

AU - McGeer, P. L.

AU - Budka, Herbert

PY - 1997

Y1 - 1997

N2 - THE expression of encephalitogenic peptide (EP), a 68-86 amino acid sequence of guinea pig myelin basic protein (MBP), was investigated in autopsied brains with focal cerebral damage or with diffuse white matter (WM) lesions. EP immunoreactive fibers were distributed in parallel with fibers immunoreactive for amyloid protein precursor (APP), an indicator of WM damages. EP was expressed in the periphery of cerebral infarctions and hematoma in the acute and subacute stages, but was also distributed in diffuse WM lesions due to heterogeneous causes. These data indicate that EP epitopes are exposed specifically in ongoing WM damages, and that the destruction of myelin occurs sporadically in diffuse WM lesions of varying intensity.

AB - THE expression of encephalitogenic peptide (EP), a 68-86 amino acid sequence of guinea pig myelin basic protein (MBP), was investigated in autopsied brains with focal cerebral damage or with diffuse white matter (WM) lesions. EP immunoreactive fibers were distributed in parallel with fibers immunoreactive for amyloid protein precursor (APP), an indicator of WM damages. EP was expressed in the periphery of cerebral infarctions and hematoma in the acute and subacute stages, but was also distributed in diffuse WM lesions due to heterogeneous causes. These data indicate that EP epitopes are exposed specifically in ongoing WM damages, and that the destruction of myelin occurs sporadically in diffuse WM lesions of varying intensity.

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AN - SCOPUS:0031438339

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VL - 8

SP - 3727

EP - 3730

JO - Neuroreport

JF - Neuroreport

IS - 17

ER -

Encephalitogenic peptide (EP) in human cerebrovascular white matter lesions

Abstract

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