Encephalopathy in scleromyxedema

Ken Johkura, K. Susuki, O. Hasegawa, Y. Kuroiwa, S. Komatsumoto

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


The authors monitored CSF findings for over 5 months in a patient with a fatal case of scleromyxedema and two episodes of encephalopathy. During both encephalopathy episodes, CSF protein and immunoglobulin G (IgG) levels were elevated without an increased IgG index or IgG synthesis rate. A CSF-dominant increase in the concentration of interleukin-6 (IL-6) also was noted during encephalopathy. These findings suggest a disruption of the blood-brain barrier and that IL-6 may play some role in mediating the encephalopathy.

Original languageEnglish
Pages (from-to)1138-1140
Number of pages3
Issue number5
Publication statusPublished - 22-09-1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Clinical Neurology


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