Encephalopathy in scleromyxedema

Ken Johkura; K. Susuki; O. Hasegawa; Y. Kuroiwa; S. Komatsumoto

doi:10.1212/wnl.53.5.1138

Encephalopathy in scleromyxedema

Ken Johkura
, K. Susuki
, O. Hasegawa
, Y. Kuroiwa
, S. Komatsumoto

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The authors monitored CSF findings for over 5 months in a patient with a fatal case of scleromyxedema and two episodes of encephalopathy. During both encephalopathy episodes, CSF protein and immunoglobulin G (IgG) levels were elevated without an increased IgG index or IgG synthesis rate. A CSF-dominant increase in the concentration of interleukin-6 (IL-6) also was noted during encephalopathy. These findings suggest a disruption of the blood-brain barrier and that IL-6 may play some role in mediating the encephalopathy.

Original language	English
Pages (from-to)	1138-1140
Number of pages	3
Journal	Neurology
Volume	53
Issue number	5
DOIs	https://doi.org/10.1212/wnl.53.5.1138
Publication status	Published - 22-09-1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

Clinical Neurology

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10.1212/wnl.53.5.1138

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AU - Johkura, Ken

AU - Susuki, K.

AU - Hasegawa, O.

AU - Kuroiwa, Y.

AU - Komatsumoto, S.

PY - 1999/9/22

Y1 - 1999/9/22

N2 - The authors monitored CSF findings for over 5 months in a patient with a fatal case of scleromyxedema and two episodes of encephalopathy. During both encephalopathy episodes, CSF protein and immunoglobulin G (IgG) levels were elevated without an increased IgG index or IgG synthesis rate. A CSF-dominant increase in the concentration of interleukin-6 (IL-6) also was noted during encephalopathy. These findings suggest a disruption of the blood-brain barrier and that IL-6 may play some role in mediating the encephalopathy.

AB - The authors monitored CSF findings for over 5 months in a patient with a fatal case of scleromyxedema and two episodes of encephalopathy. During both encephalopathy episodes, CSF protein and immunoglobulin G (IgG) levels were elevated without an increased IgG index or IgG synthesis rate. A CSF-dominant increase in the concentration of interleukin-6 (IL-6) also was noted during encephalopathy. These findings suggest a disruption of the blood-brain barrier and that IL-6 may play some role in mediating the encephalopathy.

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UR - https://www.scopus.com/pages/publications/0033595463#tab=citedBy

U2 - 10.1212/wnl.53.5.1138

DO - 10.1212/wnl.53.5.1138

M3 - Article

C2 - 10496284

AN - SCOPUS:0033595463

SN - 0028-3878

VL - 53

SP - 1138

EP - 1140

JO - Neurology

JF - Neurology

IS - 5

ER -

Encephalopathy in scleromyxedema

Abstract

All Science Journal Classification (ASJC) codes

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