Encyclopedia of EBV-encoded lytic genes: An update

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

In addition to latent genes, lytic genes of EBV must also be of extreme significance since propagation of the virus can be achieved only through execution of lytic cycle. Research on EBV lytic genes may thus prevent spreading of the virus and alleviate disorders, such as infectious mononucleosis and oral hairy leukoplakia, which are highly associated with EBV lytic infection. Moreover, recent advancements have been demonstrating that at least several lytic genes are expressed to some extent even during latent state. It is also demonstrated now that upon de novo infection, EBV expresses lytic genes in addition to latent genes before establishment of latency (this phase is called “pre-latent abortive lytic state”). In those cases, lytic genes also play important roles in cell proliferation of EBV-positive cells. However, many lytic gene products have not been identified yet nor studied thoroughly, and even worse, some have been misidentified in the literature. Here, I would like to give a detailed up-to-date review on EBV lytic genes.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages395-412
Number of pages18
DOIs
Publication statusPublished - 01-01-2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1045
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Encyclopedias
Human Herpesvirus 4
Genes
Epstein-Barr Virus Infections
Viruses
Hairy Leukoplakia
Infectious Mononucleosis
Cell proliferation
Cells
Cell Proliferation

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Murata, T. (2018). Encyclopedia of EBV-encoded lytic genes: An update. In Advances in Experimental Medicine and Biology (pp. 395-412). (Advances in Experimental Medicine and Biology; Vol. 1045). Springer New York LLC. https://doi.org/10.1007/978-981-10-7230-7_18
Murata, Takayuki. / Encyclopedia of EBV-encoded lytic genes : An update. Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. pp. 395-412 (Advances in Experimental Medicine and Biology).
@inbook{09c2e0c5591547f985a6188639a029ab,
title = "Encyclopedia of EBV-encoded lytic genes: An update",
abstract = "In addition to latent genes, lytic genes of EBV must also be of extreme significance since propagation of the virus can be achieved only through execution of lytic cycle. Research on EBV lytic genes may thus prevent spreading of the virus and alleviate disorders, such as infectious mononucleosis and oral hairy leukoplakia, which are highly associated with EBV lytic infection. Moreover, recent advancements have been demonstrating that at least several lytic genes are expressed to some extent even during latent state. It is also demonstrated now that upon de novo infection, EBV expresses lytic genes in addition to latent genes before establishment of latency (this phase is called “pre-latent abortive lytic state”). In those cases, lytic genes also play important roles in cell proliferation of EBV-positive cells. However, many lytic gene products have not been identified yet nor studied thoroughly, and even worse, some have been misidentified in the literature. Here, I would like to give a detailed up-to-date review on EBV lytic genes.",
author = "Takayuki Murata",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/978-981-10-7230-7_18",
language = "English",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "395--412",
booktitle = "Advances in Experimental Medicine and Biology",

}

Murata, T 2018, Encyclopedia of EBV-encoded lytic genes: An update. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1045, Springer New York LLC, pp. 395-412. https://doi.org/10.1007/978-981-10-7230-7_18

Encyclopedia of EBV-encoded lytic genes : An update. / Murata, Takayuki.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. p. 395-412 (Advances in Experimental Medicine and Biology; Vol. 1045).

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Encyclopedia of EBV-encoded lytic genes

T2 - An update

AU - Murata, Takayuki

PY - 2018/1/1

Y1 - 2018/1/1

N2 - In addition to latent genes, lytic genes of EBV must also be of extreme significance since propagation of the virus can be achieved only through execution of lytic cycle. Research on EBV lytic genes may thus prevent spreading of the virus and alleviate disorders, such as infectious mononucleosis and oral hairy leukoplakia, which are highly associated with EBV lytic infection. Moreover, recent advancements have been demonstrating that at least several lytic genes are expressed to some extent even during latent state. It is also demonstrated now that upon de novo infection, EBV expresses lytic genes in addition to latent genes before establishment of latency (this phase is called “pre-latent abortive lytic state”). In those cases, lytic genes also play important roles in cell proliferation of EBV-positive cells. However, many lytic gene products have not been identified yet nor studied thoroughly, and even worse, some have been misidentified in the literature. Here, I would like to give a detailed up-to-date review on EBV lytic genes.

AB - In addition to latent genes, lytic genes of EBV must also be of extreme significance since propagation of the virus can be achieved only through execution of lytic cycle. Research on EBV lytic genes may thus prevent spreading of the virus and alleviate disorders, such as infectious mononucleosis and oral hairy leukoplakia, which are highly associated with EBV lytic infection. Moreover, recent advancements have been demonstrating that at least several lytic genes are expressed to some extent even during latent state. It is also demonstrated now that upon de novo infection, EBV expresses lytic genes in addition to latent genes before establishment of latency (this phase is called “pre-latent abortive lytic state”). In those cases, lytic genes also play important roles in cell proliferation of EBV-positive cells. However, many lytic gene products have not been identified yet nor studied thoroughly, and even worse, some have been misidentified in the literature. Here, I would like to give a detailed up-to-date review on EBV lytic genes.

UR - http://www.scopus.com/inward/record.url?scp=85048641154&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048641154&partnerID=8YFLogxK

U2 - 10.1007/978-981-10-7230-7_18

DO - 10.1007/978-981-10-7230-7_18

M3 - Chapter

C2 - 29896677

AN - SCOPUS:85048641154

T3 - Advances in Experimental Medicine and Biology

SP - 395

EP - 412

BT - Advances in Experimental Medicine and Biology

PB - Springer New York LLC

ER -

Murata T. Encyclopedia of EBV-encoded lytic genes: An update. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2018. p. 395-412. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-981-10-7230-7_18