TY - JOUR
T1 - Endarteritis obliterans in the pathogenesis of buerger’s disease from the pathological and immunohistochemical points of view
AU - Kobayashi, Masayoshi
AU - Sugimoto, Masayuki
AU - Komori, Kimihiro
N1 - Publisher Copyright:
© 2014, Japanese Circulation Society. All rights reserved.
PY - 2014
Y1 - 2014
N2 - Buerger’s disease (thromboangiitis obliterans) is considered to be a nonatherosclerotic, inflammatory, and vasoocclusive disease, although the details of the mechanisms of pathogenesis remain unknown. The occurrence of the disease is strongly related to tobacco abuse and its progression is closely linked to continued smoking. The purpose of this review article is to demonstrate the pathological characteristics of arteries affected with Buerger’s disease from a possible immunoreactive point of view. In addition, we present the mechanisms for preserving the architecture of the arterial wall in affected vasculatures. Thereafter, we discuss the possibility that the pathogenesis of Buerger’s disease is a type of endarteritis obliterans, deeply connected to the Notch pathway, distinct from arteriosclerosis obliterans and other vasculitides.
AB - Buerger’s disease (thromboangiitis obliterans) is considered to be a nonatherosclerotic, inflammatory, and vasoocclusive disease, although the details of the mechanisms of pathogenesis remain unknown. The occurrence of the disease is strongly related to tobacco abuse and its progression is closely linked to continued smoking. The purpose of this review article is to demonstrate the pathological characteristics of arteries affected with Buerger’s disease from a possible immunoreactive point of view. In addition, we present the mechanisms for preserving the architecture of the arterial wall in affected vasculatures. Thereafter, we discuss the possibility that the pathogenesis of Buerger’s disease is a type of endarteritis obliterans, deeply connected to the Notch pathway, distinct from arteriosclerosis obliterans and other vasculitides.
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U2 - 10.1253/circj.CJ-14-0656
DO - 10.1253/circj.CJ-14-0656
M3 - Review article
C2 - 25298073
AN - SCOPUS:84911884613
SN - 1346-9843
VL - 78
SP - 2819
EP - 2826
JO - Circulation Journal
JF - Circulation Journal
IS - 12
ER -