Endarteritis obliterans in the pathogenesis of buerger’s disease from the pathological and immunohistochemical points of view

Masayoshi Kobayashi, Masayuki Sugimoto, Kimihiro Komori

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

Buerger’s disease (thromboangiitis obliterans) is considered to be a nonatherosclerotic, inflammatory, and vasoocclusive disease, although the details of the mechanisms of pathogenesis remain unknown. The occurrence of the disease is strongly related to tobacco abuse and its progression is closely linked to continued smoking. The purpose of this review article is to demonstrate the pathological characteristics of arteries affected with Buerger’s disease from a possible immunoreactive point of view. In addition, we present the mechanisms for preserving the architecture of the arterial wall in affected vasculatures. Thereafter, we discuss the possibility that the pathogenesis of Buerger’s disease is a type of endarteritis obliterans, deeply connected to the Notch pathway, distinct from arteriosclerosis obliterans and other vasculitides.

Original languageEnglish
Pages (from-to)2819-2826
Number of pages8
JournalCirculation Journal
Volume78
Issue number12
DOIs
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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