Endogenous human herpesviruses 6A/B

Louis Flamand; Jesse Arbuckle; Pascale Bonnafous; Vincent Descamps; Joshua A. Hill; Ruth Jarrett; Keith Jerome; Benedikt B. Kaufer; Rie Koide; Anthony L. Komaroff; Peter Medveczky; Hiroki Miura; Yasuko Mori; Nicholas Parrish; Philip E. Pellett; Michael Wood; Tetsushi Yoshikawa; Danielle M. Zerr

doi:10.1128/jvi.01054-25

Endogenous human herpesviruses 6A/B

Louis Flamand
, Jesse Arbuckle
, Pascale Bonnafous
, Vincent Descamps
, Joshua A. Hill
, Ruth Jarrett
, Keith Jerome
, Benedikt B. Kaufer
, Rie Koide
, Anthony L. Komaroff
, Peter Medveczky
, Hiroki Miura
, Yasuko Mori
, Nicholas Parrish
, Philip E. Pellett
, Michael Wood
, Tetsushi Yoshikawa
, Danielle M. Zerr

Research output: Contribution to journal › Review article › peer-review

Abstract

Human herpesviruses 6A and 6B (HHV-6A/B) can integrate into the germline, resulting in inherited viral DNA—now proposed to be called “endogenous HHV-6A/B (eHHV-6A/B).” Present in 0.2–3% of humans, this integrated DNA is passed to offspring and may reactivate, posing health risks such as angina or lupus. To reduce confusion caused by varied terminology, researchers advocate using “eHHV-6A/B” for inherited forms and reserving “chromosomally integrated” for somatic integrations only.

Original language	English
Journal	Journal of Virology
Volume	99
Issue number	9
DOIs	https://doi.org/10.1128/jvi.01054-25
Publication status	Published - 09-2025
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology
Immunology
Insect Science
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1128/jvi.01054-25

Cite this

@article{6112827cfad54436998a64ac3c11bac7,

title = "Endogenous human herpesviruses 6A/B",

abstract = "Human herpesviruses 6A and 6B (HHV-6A/B) can integrate into the germline, resulting in inherited viral DNA—now proposed to be called “endogenous HHV-6A/B (eHHV-6A/B).” Present in 0.2–3\% of humans, this integrated DNA is passed to offspring and may reactivate, posing health risks such as angina or lupus. To reduce confusion caused by varied terminology, researchers advocate using “eHHV-6A/B” for inherited forms and reserving “chromosomally integrated” for somatic integrations only.",

keywords = "eHHV-6, endogenous HHV-6, HHV-6, human herpesvirus 6, iciHHV-6, inherited chromosomally integrated HHV-6",

author = "Louis Flamand and Jesse Arbuckle and Pascale Bonnafous and Vincent Descamps and Hill, \{Joshua A.\} and Ruth Jarrett and Keith Jerome and Kaufer, \{Benedikt B.\} and Rie Koide and Komaroff, \{Anthony L.\} and Peter Medveczky and Hiroki Miura and Yasuko Mori and Nicholas Parrish and Pellett, \{Philip E.\} and Michael Wood and Tetsushi Yoshikawa and Zerr, \{Danielle M.\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2025 Flamand et al.",

year = "2025",

month = sep,

doi = "10.1128/jvi.01054-25",

language = "English",

volume = "99",

journal = "Journal of Virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

number = "9",

}

TY - JOUR

T1 - Endogenous human herpesviruses 6A/B

AU - Flamand, Louis

AU - Arbuckle, Jesse

AU - Bonnafous, Pascale

AU - Descamps, Vincent

AU - Hill, Joshua A.

AU - Jarrett, Ruth

AU - Jerome, Keith

AU - Kaufer, Benedikt B.

AU - Koide, Rie

AU - Komaroff, Anthony L.

AU - Medveczky, Peter

AU - Miura, Hiroki

AU - Mori, Yasuko

AU - Parrish, Nicholas

AU - Pellett, Philip E.

AU - Wood, Michael

AU - Yoshikawa, Tetsushi

AU - Zerr, Danielle M.

PY - 2025/9

Y1 - 2025/9

N2 - Human herpesviruses 6A and 6B (HHV-6A/B) can integrate into the germline, resulting in inherited viral DNA—now proposed to be called “endogenous HHV-6A/B (eHHV-6A/B).” Present in 0.2–3% of humans, this integrated DNA is passed to offspring and may reactivate, posing health risks such as angina or lupus. To reduce confusion caused by varied terminology, researchers advocate using “eHHV-6A/B” for inherited forms and reserving “chromosomally integrated” for somatic integrations only.

AB - Human herpesviruses 6A and 6B (HHV-6A/B) can integrate into the germline, resulting in inherited viral DNA—now proposed to be called “endogenous HHV-6A/B (eHHV-6A/B).” Present in 0.2–3% of humans, this integrated DNA is passed to offspring and may reactivate, posing health risks such as angina or lupus. To reduce confusion caused by varied terminology, researchers advocate using “eHHV-6A/B” for inherited forms and reserving “chromosomally integrated” for somatic integrations only.

KW - eHHV-6

KW - endogenous HHV-6

KW - HHV-6

KW - human herpesvirus 6

KW - iciHHV-6

KW - inherited chromosomally integrated HHV-6

UR - https://www.scopus.com/pages/publications/105016792236

UR - https://www.scopus.com/pages/publications/105016792236#tab=citedBy

U2 - 10.1128/jvi.01054-25

DO - 10.1128/jvi.01054-25

M3 - Review article

C2 - 40748144

AN - SCOPUS:105016792236

SN - 0022-538X

VL - 99

JO - Journal of Virology

JF - Journal of Virology

IS - 9

ER -

Endogenous human herpesviruses 6A/B

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this