Endoglin (CD105) is a useful marker for evaluating microvessel density and predicting prognosis in esophageal squamous cell carcinoma

Toshihide Sakurai, Hiroshi Okumura, Masataka Matsumoto, Yasuto Uchikado, Tetsuhiro Owaki, Yoshiaki Kita, Tetsuro Setoyama, Itaru Omoto, Yuko Kijima, Sumiya Ishigami, Shoji Natsugoe

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Background: Angiogenic molecular markers such as vascular endothelial growth factor and tumor microvessel density reflect prognosis of human cancers. The present study clarified the usefulness of endothelial marker endoglin (CD 105) by assessing microvessel density in esophageal squamous cell carcinoma (ESCC). Materials and Methods: We immunohistochemically investigated CD105, CD31, and vascular endothelial growth factor-A VEGF-A expression in primary esophageal squamous cell carcinoma specimens from 142 patients. Results: Microvessel density was 35.9±21.2 for CD105 and 46.3±25.4 for CD31. CD105 microvessel density was significantly associated with tumor length, tumor invasion depth, lymph node metastasis, stage, lymphatic invasion, venous invasion, and VEGF-A expression; its correlation with almost all clinicopathological parameters was stronger than CD31 microvessel density. And significantly better prognosis was achieved in patients with low, compared to high CD105, microvessel density. Conclusion: CD105 microvessel density reflected the degree of angiogenesis and prognosis in patients with esophageal squamous cell carcinoma.

Original languageEnglish
Pages (from-to)3431-3438
Number of pages8
JournalAnticancer research
Volume34
Issue number7
Publication statusPublished - 01-07-2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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