Endolymphatic hydrops and blood-labyrinth barrier in Méniè re's disease

Mitsuhiko Tagaya, Masahiro Yamazaki, Masaaki Teranishi, Shinji Naganawa, Tadao Yoshida, Hironao Otake, Seiichi Nakata, Michihiko Sone, Tsutomu Nakashima

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Abstract

Conclusions: The blood-labyrinth barrier is impaired in association with the hydrops grade in Ménière's disease. Objectives: To investigate the relationship between endolymphatic hydrops and the clinical characteristics of patients with Ménière's disease revealed by 3 T magnetic resonance imaging (MRI). Methods: A double dose of gadoteridol (Gd; 0.2 mmol/kg) was injected intravenously in 12 patients with Ménière's disease. We performed three-dimensional fluid attenuated inversion recovery MRI and three-dimensional real inversion recovery MRI 4 h later using a 3 T MRI unit. Ten patients had unilateral and two had bilateral Ménière's disease. Results: Fourteen ears with Ménière's disease showed intense Gd contrast on MRI compared with that in the 10 asymptomatic contralateral ears of patients with unilateral Ménière's disease (1.12 ± 0.36 vs 0.82 ± 0.15). The hydrops grade was correlated significantly with the contrast effect. The 14 ears with Ménière's disease had endolymphatic hydrops. Of the 10 contralateral ears of patients with unilateral Ménière's disease, 2 had endolymphatic hydrops in the cochlea and 6 had endolymphatic hydrops in the vestibule.

Original languageEnglish
Pages (from-to)474-479
Number of pages6
JournalActa Oto-Laryngologica
Volume131
Issue number5
DOIs
Publication statusPublished - 05-2011

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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    Tagaya, M., Yamazaki, M., Teranishi, M., Naganawa, S., Yoshida, T., Otake, H., Nakata, S., Sone, M., & Nakashima, T. (2011). Endolymphatic hydrops and blood-labyrinth barrier in Méniè re's disease. Acta Oto-Laryngologica, 131(5), 474-479. https://doi.org/10.3109/00016489.2010.534114