Endolymphatic hydrops revealed by intravenous gadolinium injection in patients with Ménière's disease

Tsutomu Nakashima; Shinji Naganawa; Masaaki Teranishi; Mitsuhiko Tagaya; Seiichi Nakata; Michihiko Sone; Hironao Otake; Ken Kato; Tomoyuki Iwata; Naoki Nishio

doi:10.3109/00016480903143986

Endolymphatic hydrops revealed by intravenous gadolinium injection in patients with Ménière's disease

Tsutomu Nakashima, Shinji Naganawa, Masaaki Teranishi, Mitsuhiko Tagaya, Seiichi Nakata, Michihiko Sone, Hironao Otake, Ken Kato, Tomoyuki Iwata, Naoki Nishio

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

Conclusion: Visualization of endolymphatic hydrops became possible after intravenous gadolinium (Gd) injection in patients with Ménière's disease. Objective: To visualize endolymphatic hydrops after intravenous Gd injection. Methods: Gd (gadoteridol; 0.2 mmol/kg) was injected intravenously in three patients with unilateral Ménière's disease. We performed three-dimensional fluid attenuated inversion recovery (3D-FLAIR) and three-dimensional real inversion recovery (3D-real IR) magnetic resonance imaging (MRI) 4 h after the injection using a 3-Tesla MRI unit. We used a 32-channel array coil to obtain a high signal-to-noise ratio. Results: Endolymphatic hydrops was observed in the ears of patients with Ménière's disease. However, Gd concentration in the perilymph was lower compared with that obtained after intratympanic Gd injection.

Original language	English
Pages (from-to)	338-343
Number of pages	6
Journal	Acta Oto-Laryngologica
Volume	130
Issue number	3
DOIs	https://doi.org/10.3109/00016480903143986
Publication status	Published - 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Otorhinolaryngology

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10.3109/00016480903143986

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@article{0d44b75ca3594ea0a258f79baeee8e7d,

title = "Endolymphatic hydrops revealed by intravenous gadolinium injection in patients with M{\'e}ni{\`e}re's disease",

abstract = "Conclusion: Visualization of endolymphatic hydrops became possible after intravenous gadolinium (Gd) injection in patients with M{\'e}ni{\`e}re's disease. Objective: To visualize endolymphatic hydrops after intravenous Gd injection. Methods: Gd (gadoteridol; 0.2 mmol/kg) was injected intravenously in three patients with unilateral M{\'e}ni{\`e}re's disease. We performed three-dimensional fluid attenuated inversion recovery (3D-FLAIR) and three-dimensional real inversion recovery (3D-real IR) magnetic resonance imaging (MRI) 4 h after the injection using a 3-Tesla MRI unit. We used a 32-channel array coil to obtain a high signal-to-noise ratio. Results: Endolymphatic hydrops was observed in the ears of patients with M{\'e}ni{\`e}re's disease. However, Gd concentration in the perilymph was lower compared with that obtained after intratympanic Gd injection.",

author = "Tsutomu Nakashima and Shinji Naganawa and Masaaki Teranishi and Mitsuhiko Tagaya and Seiichi Nakata and Michihiko Sone and Hironao Otake and Ken Kato and Tomoyuki Iwata and Naoki Nishio",

year = "2010",

doi = "10.3109/00016480903143986",

language = "English",

volume = "130",

pages = "338--343",

journal = "Acta Oto-Laryngologica",

issn = "0001-6489",

publisher = "Taylor and Francis Ltd.",

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TY - JOUR

T1 - Endolymphatic hydrops revealed by intravenous gadolinium injection in patients with Ménière's disease

AU - Nakashima, Tsutomu

AU - Naganawa, Shinji

AU - Teranishi, Masaaki

AU - Tagaya, Mitsuhiko

AU - Nakata, Seiichi

AU - Sone, Michihiko

AU - Otake, Hironao

AU - Kato, Ken

AU - Iwata, Tomoyuki

AU - Nishio, Naoki

PY - 2010

Y1 - 2010

N2 - Conclusion: Visualization of endolymphatic hydrops became possible after intravenous gadolinium (Gd) injection in patients with Ménière's disease. Objective: To visualize endolymphatic hydrops after intravenous Gd injection. Methods: Gd (gadoteridol; 0.2 mmol/kg) was injected intravenously in three patients with unilateral Ménière's disease. We performed three-dimensional fluid attenuated inversion recovery (3D-FLAIR) and three-dimensional real inversion recovery (3D-real IR) magnetic resonance imaging (MRI) 4 h after the injection using a 3-Tesla MRI unit. We used a 32-channel array coil to obtain a high signal-to-noise ratio. Results: Endolymphatic hydrops was observed in the ears of patients with Ménière's disease. However, Gd concentration in the perilymph was lower compared with that obtained after intratympanic Gd injection.

AB - Conclusion: Visualization of endolymphatic hydrops became possible after intravenous gadolinium (Gd) injection in patients with Ménière's disease. Objective: To visualize endolymphatic hydrops after intravenous Gd injection. Methods: Gd (gadoteridol; 0.2 mmol/kg) was injected intravenously in three patients with unilateral Ménière's disease. We performed three-dimensional fluid attenuated inversion recovery (3D-FLAIR) and three-dimensional real inversion recovery (3D-real IR) magnetic resonance imaging (MRI) 4 h after the injection using a 3-Tesla MRI unit. We used a 32-channel array coil to obtain a high signal-to-noise ratio. Results: Endolymphatic hydrops was observed in the ears of patients with Ménière's disease. However, Gd concentration in the perilymph was lower compared with that obtained after intratympanic Gd injection.

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AN - SCOPUS:77149169151

SN - 0001-6489

VL - 130

SP - 338

EP - 343

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

IS - 3

ER -

Endolymphatic hydrops revealed by intravenous gadolinium injection in patients with Ménière's disease

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