Endometrial stromal sarcoma: Clinicopathological and immunophenotypic study of 16 cases

Shin Ichi Iwasaki, Tamotsu Sudo, Maiko Miwa, Masayo Ukita, Akemi Morimoto, Masaru Tamada, Sayaka Ueno, Senn Wakahashi, Satoshi Yamaguchi, Kiyoshi Fujiwara, Yoshiko Sakuma, Yoshiki Mikami, Ryuichiro Nishimura

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Purpose: Endometrial stromal sarcomas (ESSs) are rare tumors and are divided into two groups: low-grade endometrial stromal sarcoma (ESS-LG) and undifferentiated endometrial sarcoma (UES). The purpose of this study was to compare the clinicopathological features and immunophenotypes of ESS-LG and UES. Methods: The authors evaluated 16 patients diagnosed with ESS at the Hyogo Cancer Center, reviewed their files and data, and performed an immunohistochemical study for oncogenic proteins (EGFR, PDGFR-α, and PDGFR-β) and cell cycle regulators (cyclin D1, cyclin E, p16 INK4a, p21cip1, p27kip1, and p53) to compare ESS-LG and UES using the World Health Organization (WHO) classification. Results: Four cases (25 %) were classified as ESS-LGs and 12 (75 %) as UES. Patients with UES had a significantly worse overall survival than did those with ESS-LG (p = 0.0445). Although no ESS-LGs showed expression of p16 INK4a, 10 of 12 (83 %) UESs showed expression of p16INK4a. UESs showed a trend toward higher expression of cyclin D1, p21cip1, and p53 compared with ESS-LGs. Conclusions: Our data emphasize the clinical importance of the WHO classification of ESS. It is of utmost importance to establish a proper classification to increase the consistency of data that may be useful for improving clinical and therapeutic management of patients with ESS.

Original languageEnglish
Pages (from-to)385-391
Number of pages7
JournalArchives of Gynecology and Obstetrics
Issue number2
Publication statusPublished - 08-2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology


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