TY - JOUR
T1 - Endometriosis and cancer
AU - Kajiyama, Hiroaki
AU - Suzuki, Shiro
AU - Yoshihara, Masato
AU - Tamauchi, Satoshi
AU - Yoshikawa, Nobuhisa
AU - Niimi, Kaoru
AU - Shibata, Kiyosumi
AU - Kikkawa, Fumitaka
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/3
Y1 - 2019/3
N2 - Endometriosis, characterized by the presence of extra-uterine endometrium, is a common gynecologic disorder in reproductive-age women. Although the detailed molecular mechanism of etiology remains unelucidated, recent studies have gradually revealed both genetic and epigenetic backgrounds of the development of endometriosis. In clinical practice, endometriosis has been recognized as a precursor lesion of several types of malignancies and endometriosis-associated carcinoma. An imbalance between reactive oxygen species and local antioxidants has been reported to contribute to the development of endometriosis-associated carcinoma as well as the pathophysiology of this disease through a systemic inflammatory response in the peritoneal cavity. This review mainly presents an epidemiology, possible etiology of endometriosis, precursor lesions, molecular features, and the association between the microenvironmental accumulations of oxidative stress in endometriosis-associated ovarian cancer progression.
AB - Endometriosis, characterized by the presence of extra-uterine endometrium, is a common gynecologic disorder in reproductive-age women. Although the detailed molecular mechanism of etiology remains unelucidated, recent studies have gradually revealed both genetic and epigenetic backgrounds of the development of endometriosis. In clinical practice, endometriosis has been recognized as a precursor lesion of several types of malignancies and endometriosis-associated carcinoma. An imbalance between reactive oxygen species and local antioxidants has been reported to contribute to the development of endometriosis-associated carcinoma as well as the pathophysiology of this disease through a systemic inflammatory response in the peritoneal cavity. This review mainly presents an epidemiology, possible etiology of endometriosis, precursor lesions, molecular features, and the association between the microenvironmental accumulations of oxidative stress in endometriosis-associated ovarian cancer progression.
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U2 - 10.1016/j.freeradbiomed.2018.12.015
DO - 10.1016/j.freeradbiomed.2018.12.015
M3 - Review article
C2 - 30562557
AN - SCOPUS:85059113566
SN - 0891-5849
VL - 133
SP - 186
EP - 192
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
ER -