Endonuclease analyses of DNA of human herpesvirus‐6 isolated from blood before and after bone marrow transplantation

Tetsushi Yoshikawa; Toshihiko Nakashima; Yoshizo Asano; Sadao Suga; Takehiko Yazaki; Seiji Kojima; Tetsu Mukai; Koichi Yamanishi

doi:10.1002/jmv.1890370314

Endonuclease analyses of DNA of human herpesvirus‐6 isolated from blood before and after bone marrow transplantation

Tetsushi Yoshikawa, Toshihiko Nakashima, Yoshizo Asano, Sadao Suga, Takehiko Yazaki, Seiji Kojima, Tetsu Mukai, Koichi Yamanishi

Pediatrics

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18 Citations (Scopus)

Abstract

Three strains of human herpesvirus‐6 (HHV‐6) were isolated from peripheral blood mononuclear cells of a leukemic child with the antibody of HHV‐6 before and after bone marrow transplantation (BMT); two strains were obtained before BMT and one after BMT. The DNA extracted from the three isolates was analyzed by six different restriction endonucleases. The cleavage profiles of two strains obtained before BMT were different, but the third strain isolated after BMT was identical with one of the two, which suggest reactivation of HHV‐6 from the recipient's own body after BMT and possible mutation or superinfection of the virus in an immunocompromized patient. © 1992 Wiley‐Liss, Inc.

Original language	English
Pages (from-to)	228-231
Number of pages	4
Journal	Journal of Medical Virology
Volume	37
Issue number	3
DOIs	https://doi.org/10.1002/jmv.1890370314
Publication status	Published - 07-1992

All Science Journal Classification (ASJC) codes

Virology
Infectious Diseases

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title = "Endonuclease analyses of DNA of human herpesvirus‐6 isolated from blood before and after bone marrow transplantation",

abstract = "Three strains of human herpesvirus‐6 (HHV‐6) were isolated from peripheral blood mononuclear cells of a leukemic child with the antibody of HHV‐6 before and after bone marrow transplantation (BMT); two strains were obtained before BMT and one after BMT. The DNA extracted from the three isolates was analyzed by six different restriction endonucleases. The cleavage profiles of two strains obtained before BMT were different, but the third strain isolated after BMT was identical with one of the two, which suggest reactivation of HHV‐6 from the recipient's own body after BMT and possible mutation or superinfection of the virus in an immunocompromized patient. {\textcopyright} 1992 Wiley‐Liss, Inc.",

author = "Tetsushi Yoshikawa and Toshihiko Nakashima and Yoshizo Asano and Sadao Suga and Takehiko Yazaki and Seiji Kojima and Tetsu Mukai and Koichi Yamanishi",

year = "1992",

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T1 - Endonuclease analyses of DNA of human herpesvirus‐6 isolated from blood before and after bone marrow transplantation

AU - Yoshikawa, Tetsushi

AU - Nakashima, Toshihiko

AU - Asano, Yoshizo

AU - Suga, Sadao

AU - Yazaki, Takehiko

AU - Kojima, Seiji

AU - Mukai, Tetsu

AU - Yamanishi, Koichi

PY - 1992/7

Y1 - 1992/7

N2 - Three strains of human herpesvirus‐6 (HHV‐6) were isolated from peripheral blood mononuclear cells of a leukemic child with the antibody of HHV‐6 before and after bone marrow transplantation (BMT); two strains were obtained before BMT and one after BMT. The DNA extracted from the three isolates was analyzed by six different restriction endonucleases. The cleavage profiles of two strains obtained before BMT were different, but the third strain isolated after BMT was identical with one of the two, which suggest reactivation of HHV‐6 from the recipient's own body after BMT and possible mutation or superinfection of the virus in an immunocompromized patient. © 1992 Wiley‐Liss, Inc.

AB - Three strains of human herpesvirus‐6 (HHV‐6) were isolated from peripheral blood mononuclear cells of a leukemic child with the antibody of HHV‐6 before and after bone marrow transplantation (BMT); two strains were obtained before BMT and one after BMT. The DNA extracted from the three isolates was analyzed by six different restriction endonucleases. The cleavage profiles of two strains obtained before BMT were different, but the third strain isolated after BMT was identical with one of the two, which suggest reactivation of HHV‐6 from the recipient's own body after BMT and possible mutation or superinfection of the virus in an immunocompromized patient. © 1992 Wiley‐Liss, Inc.

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Endonuclease analyses of DNA of human herpesvirus‐6 isolated from blood before and after bone marrow transplantation

Abstract

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