Abstract
Three strains of human herpesvirus‐6 (HHV‐6) were isolated from peripheral blood mononuclear cells of a leukemic child with the antibody of HHV‐6 before and after bone marrow transplantation (BMT); two strains were obtained before BMT and one after BMT. The DNA extracted from the three isolates was analyzed by six different restriction endonucleases. The cleavage profiles of two strains obtained before BMT were different, but the third strain isolated after BMT was identical with one of the two, which suggest reactivation of HHV‐6 from the recipient's own body after BMT and possible mutation or superinfection of the virus in an immunocompromized patient. © 1992 Wiley‐Liss, Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 228-231 |
| Number of pages | 4 |
| Journal | Journal of Medical Virology |
| Volume | 37 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 01-01-1992 |
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All Science Journal Classification (ASJC) codes
- Virology
- Infectious Diseases
Cite this
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Endonuclease analyses of DNA of human herpesvirus‐6 isolated from blood before and after bone marrow transplantation. / Yoshikawa, Tetsushi; Nakashima, Toshihiko; Asano, Yoshizo; Suga, Sadao; Yazaki, Takehiko; Kojima, Seiji; Mukai, Tetsu; Yamanishi, Koichi.
In: Journal of Medical Virology, Vol. 37, No. 3, 01.01.1992, p. 228-231.Research output: Contribution to journal › Article
TY - JOUR
T1 - Endonuclease analyses of DNA of human herpesvirus‐6 isolated from blood before and after bone marrow transplantation
AU - Yoshikawa, Tetsushi
AU - Nakashima, Toshihiko
AU - Asano, Yoshizo
AU - Suga, Sadao
AU - Yazaki, Takehiko
AU - Kojima, Seiji
AU - Mukai, Tetsu
AU - Yamanishi, Koichi
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Three strains of human herpesvirus‐6 (HHV‐6) were isolated from peripheral blood mononuclear cells of a leukemic child with the antibody of HHV‐6 before and after bone marrow transplantation (BMT); two strains were obtained before BMT and one after BMT. The DNA extracted from the three isolates was analyzed by six different restriction endonucleases. The cleavage profiles of two strains obtained before BMT were different, but the third strain isolated after BMT was identical with one of the two, which suggest reactivation of HHV‐6 from the recipient's own body after BMT and possible mutation or superinfection of the virus in an immunocompromized patient. © 1992 Wiley‐Liss, Inc.
AB - Three strains of human herpesvirus‐6 (HHV‐6) were isolated from peripheral blood mononuclear cells of a leukemic child with the antibody of HHV‐6 before and after bone marrow transplantation (BMT); two strains were obtained before BMT and one after BMT. The DNA extracted from the three isolates was analyzed by six different restriction endonucleases. The cleavage profiles of two strains obtained before BMT were different, but the third strain isolated after BMT was identical with one of the two, which suggest reactivation of HHV‐6 from the recipient's own body after BMT and possible mutation or superinfection of the virus in an immunocompromized patient. © 1992 Wiley‐Liss, Inc.
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U2 - 10.1002/jmv.1890370314
DO - 10.1002/jmv.1890370314
M3 - Article
VL - 37
SP - 228
EP - 231
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 3
ER -