Endonuclease analyses of DNA of human herpesvirus‐6 isolated from blood before and after bone marrow transplantation

Tetsushi Yoshikawa, Toshihiko Nakashima, Yoshizo Asano, Sadao Suga, Takehiko Yazaki, Seiji Kojima, Tetsu Mukai, Koichi Yamanishi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Three strains of human herpesvirus‐6 (HHV‐6) were isolated from peripheral blood mononuclear cells of a leukemic child with the antibody of HHV‐6 before and after bone marrow transplantation (BMT); two strains were obtained before BMT and one after BMT. The DNA extracted from the three isolates was analyzed by six different restriction endonucleases. The cleavage profiles of two strains obtained before BMT were different, but the third strain isolated after BMT was identical with one of the two, which suggest reactivation of HHV‐6 from the recipient's own body after BMT and possible mutation or superinfection of the virus in an immunocompromized patient. © 1992 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)228-231
Number of pages4
JournalJournal of Medical Virology
Volume37
Issue number3
DOIs
Publication statusPublished - 01-01-1992

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Deoxyribonuclease I
Bone Marrow Transplantation
Superinfection
DNA Restriction Enzymes
Blood Cells
Viruses
Mutation
Antibodies
DNA

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

Yoshikawa, Tetsushi ; Nakashima, Toshihiko ; Asano, Yoshizo ; Suga, Sadao ; Yazaki, Takehiko ; Kojima, Seiji ; Mukai, Tetsu ; Yamanishi, Koichi. / Endonuclease analyses of DNA of human herpesvirus‐6 isolated from blood before and after bone marrow transplantation. In: Journal of Medical Virology. 1992 ; Vol. 37, No. 3. pp. 228-231.
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Endonuclease analyses of DNA of human herpesvirus‐6 isolated from blood before and after bone marrow transplantation. / Yoshikawa, Tetsushi; Nakashima, Toshihiko; Asano, Yoshizo; Suga, Sadao; Yazaki, Takehiko; Kojima, Seiji; Mukai, Tetsu; Yamanishi, Koichi.

In: Journal of Medical Virology, Vol. 37, No. 3, 01.01.1992, p. 228-231.

Research output: Contribution to journalArticle

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AU - Yoshikawa, Tetsushi

AU - Nakashima, Toshihiko

AU - Asano, Yoshizo

AU - Suga, Sadao

AU - Yazaki, Takehiko

AU - Kojima, Seiji

AU - Mukai, Tetsu

AU - Yamanishi, Koichi

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AB - Three strains of human herpesvirus‐6 (HHV‐6) were isolated from peripheral blood mononuclear cells of a leukemic child with the antibody of HHV‐6 before and after bone marrow transplantation (BMT); two strains were obtained before BMT and one after BMT. The DNA extracted from the three isolates was analyzed by six different restriction endonucleases. The cleavage profiles of two strains obtained before BMT were different, but the third strain isolated after BMT was identical with one of the two, which suggest reactivation of HHV‐6 from the recipient's own body after BMT and possible mutation or superinfection of the virus in an immunocompromized patient. © 1992 Wiley‐Liss, Inc.

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