Endonuclease analyses of DNA of human herpesvirus‐6 isolated from blood before and after bone marrow transplantation

Tetsushi Yoshikawa, Toshihiko Nakashima, Yoshizo Asano, Sadao Suga, Takehiko Yazaki, Seiji Kojima, Tetsu Mukai, Koichi Yamanishi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Three strains of human herpesvirus‐6 (HHV‐6) were isolated from peripheral blood mononuclear cells of a leukemic child with the antibody of HHV‐6 before and after bone marrow transplantation (BMT); two strains were obtained before BMT and one after BMT. The DNA extracted from the three isolates was analyzed by six different restriction endonucleases. The cleavage profiles of two strains obtained before BMT were different, but the third strain isolated after BMT was identical with one of the two, which suggest reactivation of HHV‐6 from the recipient's own body after BMT and possible mutation or superinfection of the virus in an immunocompromized patient. © 1992 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)228-231
Number of pages4
JournalJournal of Medical Virology
Volume37
Issue number3
DOIs
Publication statusPublished - 07-1992

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

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