Endorphins do not affect behavioral stress responses in mice

Akira Katoh, Toshitaka Nabeshima, Reiko Ukai, Tsutomu Kameyama

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Effects of endorphins on behavioral stress responses were investigated in mice. For this purpose, we used environment-induced conditioned suppression of motility and forced swimming-induced immobility. The cerebral ventricular administration of α-endorphin (2.5-10 nmol), β-endorphin (0.38-1.5 nmol), or γ-endorphin (2.5-10 nmol) failed to affect either the environment-induced conditioned suppression of motility or the forced swimming-induced immobility. We have indicated previously that enkephalins attenuate both stress responses and, in contrast, dynorphin potentiates them. These findings indicate that the endorphinergic systems are not responsible for behavioral stress responses and that the role played by endorphins in the present stressful situations may be different from that of enkephalin and dynorphin.

Original languageEnglish
Pages (from-to)737-739
Number of pages3
JournalPeptides
Volume13
Issue number4
DOIs
Publication statusPublished - 01-01-1992
Externally publishedYes

Fingerprint

Endorphins
Dynorphins
Enkephalins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Katoh, Akira ; Nabeshima, Toshitaka ; Ukai, Reiko ; Kameyama, Tsutomu. / Endorphins do not affect behavioral stress responses in mice. In: Peptides. 1992 ; Vol. 13, No. 4. pp. 737-739.
@article{41203a1a5fb248fe8cafcf546d5f94ea,
title = "Endorphins do not affect behavioral stress responses in mice",
abstract = "Effects of endorphins on behavioral stress responses were investigated in mice. For this purpose, we used environment-induced conditioned suppression of motility and forced swimming-induced immobility. The cerebral ventricular administration of α-endorphin (2.5-10 nmol), β-endorphin (0.38-1.5 nmol), or γ-endorphin (2.5-10 nmol) failed to affect either the environment-induced conditioned suppression of motility or the forced swimming-induced immobility. We have indicated previously that enkephalins attenuate both stress responses and, in contrast, dynorphin potentiates them. These findings indicate that the endorphinergic systems are not responsible for behavioral stress responses and that the role played by endorphins in the present stressful situations may be different from that of enkephalin and dynorphin.",
author = "Akira Katoh and Toshitaka Nabeshima and Reiko Ukai and Tsutomu Kameyama",
year = "1992",
month = "1",
day = "1",
doi = "10.1016/0196-9781(92)90180-B",
language = "English",
volume = "13",
pages = "737--739",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier Inc.",
number = "4",

}

Endorphins do not affect behavioral stress responses in mice. / Katoh, Akira; Nabeshima, Toshitaka; Ukai, Reiko; Kameyama, Tsutomu.

In: Peptides, Vol. 13, No. 4, 01.01.1992, p. 737-739.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Endorphins do not affect behavioral stress responses in mice

AU - Katoh, Akira

AU - Nabeshima, Toshitaka

AU - Ukai, Reiko

AU - Kameyama, Tsutomu

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Effects of endorphins on behavioral stress responses were investigated in mice. For this purpose, we used environment-induced conditioned suppression of motility and forced swimming-induced immobility. The cerebral ventricular administration of α-endorphin (2.5-10 nmol), β-endorphin (0.38-1.5 nmol), or γ-endorphin (2.5-10 nmol) failed to affect either the environment-induced conditioned suppression of motility or the forced swimming-induced immobility. We have indicated previously that enkephalins attenuate both stress responses and, in contrast, dynorphin potentiates them. These findings indicate that the endorphinergic systems are not responsible for behavioral stress responses and that the role played by endorphins in the present stressful situations may be different from that of enkephalin and dynorphin.

AB - Effects of endorphins on behavioral stress responses were investigated in mice. For this purpose, we used environment-induced conditioned suppression of motility and forced swimming-induced immobility. The cerebral ventricular administration of α-endorphin (2.5-10 nmol), β-endorphin (0.38-1.5 nmol), or γ-endorphin (2.5-10 nmol) failed to affect either the environment-induced conditioned suppression of motility or the forced swimming-induced immobility. We have indicated previously that enkephalins attenuate both stress responses and, in contrast, dynorphin potentiates them. These findings indicate that the endorphinergic systems are not responsible for behavioral stress responses and that the role played by endorphins in the present stressful situations may be different from that of enkephalin and dynorphin.

UR - http://www.scopus.com/inward/record.url?scp=0026471078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026471078&partnerID=8YFLogxK

U2 - 10.1016/0196-9781(92)90180-B

DO - 10.1016/0196-9781(92)90180-B

M3 - Article

C2 - 1437715

AN - SCOPUS:0026471078

VL - 13

SP - 737

EP - 739

JO - Peptides

JF - Peptides

SN - 0196-9781

IS - 4

ER -