Engraftment syndrome following allogeneic hematopoietic stem cell transplantation in children

Nobuhiro Nishio, Hiroshi Yagasaki, Yoshiyuki Takahashi, Asahito Hama, Hideki Muramatsu, Makito Tanaka, Nao Yoshida, Ayami Yoshimi, Kazuko Kudo, Masafumi Ito, Seiji Kojima

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


ES is a complication that occurs immediately before or at the timing of neutrophil engraftment following autologous or allogeneic SCT. It is characterized by fever, skin rash, and non-cardiac pulmonary infiltrates. We evaluated the incidence, risk factors, and outcomes of ES following allogeneic SCT in children. Of 100 pediatric patients, 20 (20%) developed ES occurring at a median of 14 days (range 8-27 days) post-transplant. Patients presented with fever (100%), skin rash (100%), diffuse pulmonary infiltration (25%), and body weight gain (85%). On multivariate analysis, significant risk factors for ES included younger age (<8 yr old) and human leukocyte antigen disparity between donors and recipients. Univariate analysis showed that patients with ES had a higher incidence of developing chronic graft-versus-host disease and ES was not associated with other complications. Event-free survival did not significantly differ between patients with and without ES regardless of the presence of malignant or non-malignant diseases.

Original languageEnglish
Pages (from-to)831-837
Number of pages7
JournalPediatric Transplantation
Issue number7
Publication statusPublished - 11-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Transplantation


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