TY - JOUR
T1 - Engraftment syndrome following allogeneic hematopoietic stem cell transplantation in children
AU - Nishio, Nobuhiro
AU - Yagasaki, Hiroshi
AU - Takahashi, Yoshiyuki
AU - Hama, Asahito
AU - Muramatsu, Hideki
AU - Tanaka, Makito
AU - Yoshida, Nao
AU - Yoshimi, Ayami
AU - Kudo, Kazuko
AU - Ito, Masafumi
AU - Kojima, Seiji
PY - 2009/11
Y1 - 2009/11
N2 - ES is a complication that occurs immediately before or at the timing of neutrophil engraftment following autologous or allogeneic SCT. It is characterized by fever, skin rash, and non-cardiac pulmonary infiltrates. We evaluated the incidence, risk factors, and outcomes of ES following allogeneic SCT in children. Of 100 pediatric patients, 20 (20%) developed ES occurring at a median of 14 days (range 8-27 days) post-transplant. Patients presented with fever (100%), skin rash (100%), diffuse pulmonary infiltration (25%), and body weight gain (85%). On multivariate analysis, significant risk factors for ES included younger age (<8 yr old) and human leukocyte antigen disparity between donors and recipients. Univariate analysis showed that patients with ES had a higher incidence of developing chronic graft-versus-host disease and ES was not associated with other complications. Event-free survival did not significantly differ between patients with and without ES regardless of the presence of malignant or non-malignant diseases.
AB - ES is a complication that occurs immediately before or at the timing of neutrophil engraftment following autologous or allogeneic SCT. It is characterized by fever, skin rash, and non-cardiac pulmonary infiltrates. We evaluated the incidence, risk factors, and outcomes of ES following allogeneic SCT in children. Of 100 pediatric patients, 20 (20%) developed ES occurring at a median of 14 days (range 8-27 days) post-transplant. Patients presented with fever (100%), skin rash (100%), diffuse pulmonary infiltration (25%), and body weight gain (85%). On multivariate analysis, significant risk factors for ES included younger age (<8 yr old) and human leukocyte antigen disparity between donors and recipients. Univariate analysis showed that patients with ES had a higher incidence of developing chronic graft-versus-host disease and ES was not associated with other complications. Event-free survival did not significantly differ between patients with and without ES regardless of the presence of malignant or non-malignant diseases.
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U2 - 10.1111/j.1399-3046.2008.01068.x
DO - 10.1111/j.1399-3046.2008.01068.x
M3 - Article
C2 - 19067915
AN - SCOPUS:70349956585
VL - 13
SP - 831
EP - 837
JO - Pediatric Transplantation
JF - Pediatric Transplantation
SN - 1397-3142
IS - 7
ER -