Engrailed and tectum development

Minoru Omi, Harukazu Nakamura

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)


The optic tectum is a visual center of nonmammalian vertebrates derived from the mesencephalon. In this review, function of Engrailed (En) in tectum development is reviewed. En plays crucial roles at three steps of tectum development. First, Engrailed is expressed in the mesencephalon and the metencephalon and essential for the regionalization of the mesencephalon. En is expressed in a gradient of caudal-to-rostral in the tectum primordial, and regulates the rostrocaudal polarity of the tectum. In the advanced stage of tectum development, En is expressed in a lamina-specific manner and it is suggested that En regulates cell migration in the tectal laminar formation.

Original languageEnglish
Pages (from-to)135-145
Number of pages11
JournalDevelopment Growth and Differentiation
Issue number2
Publication statusPublished - 01-02-2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology


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