Enhanced effect of clarithromycin on neutrophil function in vitro

H. Akamatsu, Y. Niwa, H. Sasaki, Y. Asada, T. Horio

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


An in vitro study was carried out to investigate the effect of clarithromycin, a new oral macrolide, on neutrophil reactive oxygen species generation and chemotaxis. It was found that neutrophil-generated O2-, H2O2 and OH. levels were significantly increased by clarithromycin at concentrations of 50 μg/ml (P < 0.05). The drug also significantly increased chemotaxis (P < 0.05). These results indicate that clarithromycin may enhance the activation of neutrophils in vivo.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalJournal of International Medical Research
Issue number2
Publication statusPublished - 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical


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