Enhanced effect of clarithromycin on neutrophil function in vitro

H. Akamatsu; Y. Niwa; H. Sasaki; Y. Asada; T. Horio

doi:10.1177/030006059602400202

Enhanced effect of clarithromycin on neutrophil function in vitro

H. Akamatsu, Y. Niwa, H. Sasaki, Y. Asada, T. Horio

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

An in vitro study was carried out to investigate the effect of clarithromycin, a new oral macrolide, on neutrophil reactive oxygen species generation and chemotaxis. It was found that neutrophil-generated O₂^-, H₂O₂ and OH. levels were significantly increased by clarithromycin at concentrations of 50 μg/ml (P < 0.05). The drug also significantly increased chemotaxis (P < 0.05). These results indicate that clarithromycin may enhance the activation of neutrophils in vivo.

Original language	English
Pages (from-to)	185-189
Number of pages	5
Journal	Journal of International Medical Research
Volume	24
Issue number	2
DOIs	https://doi.org/10.1177/030006059602400202
Publication status	Published - 1996
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Cell Biology
Biochemistry, medical

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abstract = "An in vitro study was carried out to investigate the effect of clarithromycin, a new oral macrolide, on neutrophil reactive oxygen species generation and chemotaxis. It was found that neutrophil-generated O2-, H2O2 and OH. levels were significantly increased by clarithromycin at concentrations of 50 μg/ml (P < 0.05). The drug also significantly increased chemotaxis (P < 0.05). These results indicate that clarithromycin may enhance the activation of neutrophils in vivo.",

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AU - Niwa, Y.

AU - Sasaki, H.

AU - Asada, Y.

AU - Horio, T.

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AB - An in vitro study was carried out to investigate the effect of clarithromycin, a new oral macrolide, on neutrophil reactive oxygen species generation and chemotaxis. It was found that neutrophil-generated O2-, H2O2 and OH. levels were significantly increased by clarithromycin at concentrations of 50 μg/ml (P < 0.05). The drug also significantly increased chemotaxis (P < 0.05). These results indicate that clarithromycin may enhance the activation of neutrophils in vivo.

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