TY - JOUR
T1 - Enhanced effect of clarithromycin on neutrophil function in vitro
AU - Akamatsu, H.
AU - Niwa, Y.
AU - Sasaki, H.
AU - Asada, Y.
AU - Horio, T.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1996
Y1 - 1996
N2 - An in vitro study was carried out to investigate the effect of clarithromycin, a new oral macrolide, on neutrophil reactive oxygen species generation and chemotaxis. It was found that neutrophil-generated O2-, H2O2 and OH. levels were significantly increased by clarithromycin at concentrations of 50 μg/ml (P < 0.05). The drug also significantly increased chemotaxis (P < 0.05). These results indicate that clarithromycin may enhance the activation of neutrophils in vivo.
AB - An in vitro study was carried out to investigate the effect of clarithromycin, a new oral macrolide, on neutrophil reactive oxygen species generation and chemotaxis. It was found that neutrophil-generated O2-, H2O2 and OH. levels were significantly increased by clarithromycin at concentrations of 50 μg/ml (P < 0.05). The drug also significantly increased chemotaxis (P < 0.05). These results indicate that clarithromycin may enhance the activation of neutrophils in vivo.
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U2 - 10.1177/030006059602400202
DO - 10.1177/030006059602400202
M3 - Article
C2 - 8737228
AN - SCOPUS:0030010252
VL - 24
SP - 185
EP - 189
JO - Journal of International Medical Research
JF - Journal of International Medical Research
SN - 0300-0605
IS - 2
ER -