Abstract
An in vitro study was carried out to investigate the effect of clarithromycin, a new oral macrolide, on neutrophil reactive oxygen species generation and chemotaxis. It was found that neutrophil-generated O2-, H2O2 and OH. levels were significantly increased by clarithromycin at concentrations of 50 μg/ml (P < 0.05). The drug also significantly increased chemotaxis (P < 0.05). These results indicate that clarithromycin may enhance the activation of neutrophils in vivo.
Original language | English |
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Pages (from-to) | 185-189 |
Number of pages | 5 |
Journal | Journal of International Medical Research |
Volume | 24 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1996 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Cell Biology
- Biochemistry, medical