Enhanced expression of translation factor mRNAs in hepatocellular carcinoma

Masahiro Shuda, Nobuo Kondoh, Kenji Tanaka, Akihide Ryo, Toru Wakatsuki, Akiyuki Hada, Narihide Goseki, Toru Igari, Kazuo Hatsuse, Tsukasa Aihara, Sankichi Horiuchi, Mizue Shichita, Naoki Yamamoto, Mikio Yamamoto

Research output: Contribution to journalArticlepeer-review

120 Citations (Scopus)

Abstract

Several studies have demonstrated elevated expression of translation factor mRNAs in malignant tissues. In this study, using primary human hepatocellular carcinoma (HCC) tissues, we examined gene expression of translation factors, including 2 eukaryotic initiation factors (eIFs-4A1, -4E), 4 elongation factors (eEFs-1α, -1γ, -1δ, and -2) and 10 ribosomal proteins (Rps P1, P2, S10, L35, L5, L39, L9, L6, S3a and S17), whose mRNA expression has never been examined in HCC. Our results demonstrated that all the mRNAs examined were up-regulated in HCC tissues. Among 7 HCC tissues of different histological grades, the expression of these mRNAs remained at basal levels in a well to moderately differentiated (W/M-) HCC, was coordinately up-regulated in moderately differentiated (M-) HCCs. In moderately to poorly differentiated (M/P-) HCCs, the expression of eEFs-1γ, -1δ, -2, Rps P0 and L9 mRNAs was further up-regulated along with the histological grading. These results therefore suggest that coordination and specific activation of translation factor genes might be involved in the process of liver carcinogenesis.

Original languageEnglish
Pages (from-to)2489-2494
Number of pages6
JournalAnticancer research
Volume20
Issue number4
Publication statusPublished - 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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