TY - JOUR
T1 - Enhanced expression of translation factor mRNAs in hepatocellular carcinoma
AU - Shuda, Masahiro
AU - Kondoh, Nobuo
AU - Tanaka, Kenji
AU - Ryo, Akihide
AU - Wakatsuki, Toru
AU - Hada, Akiyuki
AU - Goseki, Narihide
AU - Igari, Toru
AU - Hatsuse, Kazuo
AU - Aihara, Tsukasa
AU - Horiuchi, Sankichi
AU - Shichita, Mizue
AU - Yamamoto, Naoki
AU - Yamamoto, Mikio
PY - 2000
Y1 - 2000
N2 - Several studies have demonstrated elevated expression of translation factor mRNAs in malignant tissues. In this study, using primary human hepatocellular carcinoma (HCC) tissues, we examined gene expression of translation factors, including 2 eukaryotic initiation factors (eIFs-4A1, -4E), 4 elongation factors (eEFs-1α, -1γ, -1δ, and -2) and 10 ribosomal proteins (Rps P1, P2, S10, L35, L5, L39, L9, L6, S3a and S17), whose mRNA expression has never been examined in HCC. Our results demonstrated that all the mRNAs examined were up-regulated in HCC tissues. Among 7 HCC tissues of different histological grades, the expression of these mRNAs remained at basal levels in a well to moderately differentiated (W/M-) HCC, was coordinately up-regulated in moderately differentiated (M-) HCCs. In moderately to poorly differentiated (M/P-) HCCs, the expression of eEFs-1γ, -1δ, -2, Rps P0 and L9 mRNAs was further up-regulated along with the histological grading. These results therefore suggest that coordination and specific activation of translation factor genes might be involved in the process of liver carcinogenesis.
AB - Several studies have demonstrated elevated expression of translation factor mRNAs in malignant tissues. In this study, using primary human hepatocellular carcinoma (HCC) tissues, we examined gene expression of translation factors, including 2 eukaryotic initiation factors (eIFs-4A1, -4E), 4 elongation factors (eEFs-1α, -1γ, -1δ, and -2) and 10 ribosomal proteins (Rps P1, P2, S10, L35, L5, L39, L9, L6, S3a and S17), whose mRNA expression has never been examined in HCC. Our results demonstrated that all the mRNAs examined were up-regulated in HCC tissues. Among 7 HCC tissues of different histological grades, the expression of these mRNAs remained at basal levels in a well to moderately differentiated (W/M-) HCC, was coordinately up-regulated in moderately differentiated (M-) HCCs. In moderately to poorly differentiated (M/P-) HCCs, the expression of eEFs-1γ, -1δ, -2, Rps P0 and L9 mRNAs was further up-regulated along with the histological grading. These results therefore suggest that coordination and specific activation of translation factor genes might be involved in the process of liver carcinogenesis.
KW - Enhanced
KW - Expression
KW - Hepatocellular carcinoma
KW - Translation factors
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M3 - Article
C2 - 10953316
AN - SCOPUS:0033855877
SN - 0250-7005
VL - 20
SP - 2489
EP - 2494
JO - Anticancer research
JF - Anticancer research
IS - 4
ER -
