Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule

Kazuhiro Nakamura, Toshiya Manabe, Masahiko Watanabe, Takayoshi Mamiya, Ryoichi Ichikawa, Yuji Kiyama, Makoto Sanbo, Takeshi Yagi, Yoshiro Inoue, Toshitaka Nabeshima, Hisashi Mori, Masayoshi Mishina

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Telencephalin (TLCN) is a cell adhesion molecule selectively expressed in the telencephalon of the mammalian brain. The mutant mice lacking TLCN had no detectable abnormalities in their neural development and synaptic structures. Ablation of TLCN increased the hippocampal long-term potentiation and its saturation level. The TLCN mutation selectively enhanced the performance of the radial maze and water-finding tasks, learning tasks with appetitive reinforcers, but not the contextual fear conditioning and Morris water maze tasks with aversive stimuli for conditioning. Furthermore, the TLCN mutant mice showed an increase of prepulse inhibition of the acoustic startle response. These results suggest that TLCN is a determinant of the dynamic range of synaptic plasticity and plays roles in reward-motivated learning and memory and sensorimotor gating.

Original languageEnglish
Pages (from-to)179-189
Number of pages11
JournalEuropean Journal of Neuroscience
Volume13
Issue number1
DOIs
Publication statusPublished - 30-01-2001
Externally publishedYes

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Sensory Gating
Telencephalon
Cell Adhesion Molecules
Startle Reflex
Learning
Neuronal Plasticity
Water
Long-Term Potentiation
Reward
Acoustics
Fear
Mutation
Brain
Mouse Icam5 protein
Conditioning (Psychology)
Prepulse Inhibition

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Nakamura, Kazuhiro ; Manabe, Toshiya ; Watanabe, Masahiko ; Mamiya, Takayoshi ; Ichikawa, Ryoichi ; Kiyama, Yuji ; Sanbo, Makoto ; Yagi, Takeshi ; Inoue, Yoshiro ; Nabeshima, Toshitaka ; Mori, Hisashi ; Mishina, Masayoshi. / Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule. In: European Journal of Neuroscience. 2001 ; Vol. 13, No. 1. pp. 179-189.
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Nakamura, K, Manabe, T, Watanabe, M, Mamiya, T, Ichikawa, R, Kiyama, Y, Sanbo, M, Yagi, T, Inoue, Y, Nabeshima, T, Mori, H & Mishina, M 2001, 'Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule', European Journal of Neuroscience, vol. 13, no. 1, pp. 179-189. https://doi.org/10.1046/j.0953-816X.2000.01366.x

Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule. / Nakamura, Kazuhiro; Manabe, Toshiya; Watanabe, Masahiko; Mamiya, Takayoshi; Ichikawa, Ryoichi; Kiyama, Yuji; Sanbo, Makoto; Yagi, Takeshi; Inoue, Yoshiro; Nabeshima, Toshitaka; Mori, Hisashi; Mishina, Masayoshi.

In: European Journal of Neuroscience, Vol. 13, No. 1, 30.01.2001, p. 179-189.

Research output: Contribution to journalArticle

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AU - Nakamura, Kazuhiro

AU - Manabe, Toshiya

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AU - Ichikawa, Ryoichi

AU - Kiyama, Yuji

AU - Sanbo, Makoto

AU - Yagi, Takeshi

AU - Inoue, Yoshiro

AU - Nabeshima, Toshitaka

AU - Mori, Hisashi

AU - Mishina, Masayoshi

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