TY - JOUR
T1 - Enhancement of immobility induced by repeated phencyclidine injection
T2 - Association with c-Fos protein in the mouse brain
AU - Abdel-Naby Sayed, Merfat
AU - Noda, Yukihiro
AU - Mahmoud Hamdy, Moustafa
AU - Mamiya, Takayoshi
AU - Nagai, Taku
AU - Furukawa, Hiroshi
AU - Nabeshima, Toshitaka
N1 - Funding Information:
This work was supported, in part, by a Grant-in-Aid for COE Research and Scientific Research (10044260) (12922097) from the Ministry of Education, Science, Sports and Culture of Japan, by Special Coordination Funds for Promoting Science and Technology, the Target-oriented Brain Science Research Program, from the Ministry of Science and Technology of Japan and by Health Scientific Research Grants for Research on Pharmaceutical and Medical Safety from the Ministry of Health and Welfare of Japan.
PY - 2001
Y1 - 2001
N2 - Immunohistochemistry of c-Fos protein was performed to study changes in neuronal activity in discrete brain areas of mice repeatedly treated with phencyclidine (PCP) showing enhancement of immobility in the forced swimming test, this behavioral change being considered as avolition, which is one of negative symptoms of schizophrenia. Repeated treatment with PCP significantly prolonged immobility time in the forced swimming test, compared with saline treatment. The c-Fos protein expression of mice showing PCP-induced enhancement of immobility was increased in certain brain regions, such as the retrosplenial cortex, pyriform cortices, pontine nuclei, cingulate, frontal cortex and thalamus, compared with that of PCP-treated, non-swimming and saline-treated, swimming groups. These results suggest that increased c-Fos protein is involved in the expression of PCP-induced enhancement of immobility, and c-Fos expression plays a role in negative symptoms-like behavioral changes.
AB - Immunohistochemistry of c-Fos protein was performed to study changes in neuronal activity in discrete brain areas of mice repeatedly treated with phencyclidine (PCP) showing enhancement of immobility in the forced swimming test, this behavioral change being considered as avolition, which is one of negative symptoms of schizophrenia. Repeated treatment with PCP significantly prolonged immobility time in the forced swimming test, compared with saline treatment. The c-Fos protein expression of mice showing PCP-induced enhancement of immobility was increased in certain brain regions, such as the retrosplenial cortex, pyriform cortices, pontine nuclei, cingulate, frontal cortex and thalamus, compared with that of PCP-treated, non-swimming and saline-treated, swimming groups. These results suggest that increased c-Fos protein is involved in the expression of PCP-induced enhancement of immobility, and c-Fos expression plays a role in negative symptoms-like behavioral changes.
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U2 - 10.1016/S0166-4328(01)00235-2
DO - 10.1016/S0166-4328(01)00235-2
M3 - Article
C2 - 11423167
AN - SCOPUS:0034979981
SN - 0166-4328
VL - 124
SP - 71
EP - 76
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -