Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway

Houman Goudarzi; Hisashi Iizasa; Masako Furuhashi; Seitaro Nakazawa; Rie Nakane; Shanshan Liang; Yasuhiro Hida; Kazuyoshi Yanagihara; Takanori Kubo; Koji Nakagawa; Masanobu Kobayashi; Tatsuro Irimura; Jun ichi Hamada

doi:10.1016/j.canlet.2013.07.020

Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway

Houman Goudarzi, Hisashi Iizasa, Masako Furuhashi, Seitaro Nakazawa, Rie Nakane, Shanshan Liang, Yasuhiro Hida, Kazuyoshi Yanagihara, Takanori Kubo, Koji Nakagawa, Masanobu Kobayashi, Tatsuro Irimura, Jun ichi Hamada

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

In this study, we examined the effects of hypoxia on the malignancy of human malignant pleural mesothelioma (MPM) cell lines, and found (1) hypoxia enhanced motility and invasiveness of human malignant pleural mesothelioma (MPM) cells; (2) this phenomenon resulted from increased expression of sialylated MUC1 through the activation of HIF-1 pathway; (3) two HIF-binding sites located in the promoter region of MUC1 were important for MUC1 transactivation under hypoxia. These findings are useful for better understanding molecular mechanisms of aggressive behavior of MPM cells and for targeting them in the clinical therapies for MPM patients.

Original language	English
Pages (from-to)	82-92
Number of pages	11
Journal	Cancer Letters
Volume	339
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2013.07.020
Publication status	Published - 01-10-2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2013.07.020

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Goudarzi, H., Iizasa, H., Furuhashi, M., Nakazawa, S., Nakane, R., Liang, S., Hida, Y., Yanagihara, K., Kubo, T., Nakagawa, K., Kobayashi, M., Irimura, T., & Hamada, J. I. (2013). Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway. Cancer Letters, 339(1), 82-92. https://doi.org/10.1016/j.canlet.2013.07.020

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title = "Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway",

abstract = "In this study, we examined the effects of hypoxia on the malignancy of human malignant pleural mesothelioma (MPM) cell lines, and found (1) hypoxia enhanced motility and invasiveness of human malignant pleural mesothelioma (MPM) cells; (2) this phenomenon resulted from increased expression of sialylated MUC1 through the activation of HIF-1 pathway; (3) two HIF-binding sites located in the promoter region of MUC1 were important for MUC1 transactivation under hypoxia. These findings are useful for better understanding molecular mechanisms of aggressive behavior of MPM cells and for targeting them in the clinical therapies for MPM patients.",

author = "Houman Goudarzi and Hisashi Iizasa and Masako Furuhashi and Seitaro Nakazawa and Rie Nakane and Shanshan Liang and Yasuhiro Hida and Kazuyoshi Yanagihara and Takanori Kubo and Koji Nakagawa and Masanobu Kobayashi and Tatsuro Irimura and Hamada, {Jun ichi}",

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Goudarzi, H, Iizasa, H, Furuhashi, M, Nakazawa, S, Nakane, R, Liang, S, Hida, Y, Yanagihara, K, Kubo, T, Nakagawa, K, Kobayashi, M, Irimura, T & Hamada, JI 2013, 'Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway', Cancer Letters, vol. 339, no. 1, pp. 82-92. https://doi.org/10.1016/j.canlet.2013.07.020

TY - JOUR

T1 - Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway

AU - Goudarzi, Houman

AU - Iizasa, Hisashi

AU - Furuhashi, Masako

AU - Nakazawa, Seitaro

AU - Nakane, Rie

AU - Liang, Shanshan

AU - Hida, Yasuhiro

AU - Yanagihara, Kazuyoshi

AU - Kubo, Takanori

AU - Nakagawa, Koji

AU - Kobayashi, Masanobu

AU - Irimura, Tatsuro

AU - Hamada, Jun ichi

PY - 2013/10/1

Y1 - 2013/10/1

N2 - In this study, we examined the effects of hypoxia on the malignancy of human malignant pleural mesothelioma (MPM) cell lines, and found (1) hypoxia enhanced motility and invasiveness of human malignant pleural mesothelioma (MPM) cells; (2) this phenomenon resulted from increased expression of sialylated MUC1 through the activation of HIF-1 pathway; (3) two HIF-binding sites located in the promoter region of MUC1 were important for MUC1 transactivation under hypoxia. These findings are useful for better understanding molecular mechanisms of aggressive behavior of MPM cells and for targeting them in the clinical therapies for MPM patients.

AB - In this study, we examined the effects of hypoxia on the malignancy of human malignant pleural mesothelioma (MPM) cell lines, and found (1) hypoxia enhanced motility and invasiveness of human malignant pleural mesothelioma (MPM) cells; (2) this phenomenon resulted from increased expression of sialylated MUC1 through the activation of HIF-1 pathway; (3) two HIF-binding sites located in the promoter region of MUC1 were important for MUC1 transactivation under hypoxia. These findings are useful for better understanding molecular mechanisms of aggressive behavior of MPM cells and for targeting them in the clinical therapies for MPM patients.

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Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway

Abstract

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