Enhancement of in vivo anticancer effects of cisplatin by incorporation inside single-wall carbon nanohorns

Kumiko Ajima, Tatsuya Murakami, Yoshikazu Mizoguchi, Kunihiro Tsuchida, Toshinari Ichihashi, Sumio Iijima, Masako Yudasaka

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

Cisplatin (CDDP) was incorporated inside single-wall carbon nanohoms with holes opened (SWNHox) by a nanoprecipitation method that involved dispersion of CDDP and SWNHox in a solvent followed by the solvent evaporation. The incorporated CDDP quantity increased from the previously reported value of 15 to 46%, and the total released quantity of CDDP also increased from 60 to 100% by changing the solvent from dimethylformamide to water. Concurrently, in vitro anticancer efficiency of CDDPΣWNHox increased to 4-6 times greater than that of the intact CDDP. In vivo, CDDPΣWNHox intratumorally injected to transplanted tumors of mice suppressed the tumor growth more than the intact CDDP. We observed that CDDPΣWRHox adhered to the cell surfaces in vitro and stayed within the tumor tissues in vivo. Therefore, we think that the CDDP released from SWNHox realized high concentrations locally at the cells in vitro and in the tissues in vivo and could efficiently attack the tumor cells. We also found that SWNHox itself had an in vivo anticancer effect, which might increase the anticancer activities of CDDPΣWNHox.

Original languageEnglish
Pages (from-to)2057-2064
Number of pages8
JournalACS Nano
Volume2
Issue number10
DOIs
Publication statusPublished - 01-10-2008

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Nanohorns
Cisplatin
Tumors
tumors
Carbon
augmentation
carbon
Tissue
Dimethylformamide
cells
attack
mice
Evaporation
Cells
evaporation
Water
water

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Ajima, K., Murakami, T., Mizoguchi, Y., Tsuchida, K., Ichihashi, T., Iijima, S., & Yudasaka, M. (2008). Enhancement of in vivo anticancer effects of cisplatin by incorporation inside single-wall carbon nanohorns. ACS Nano, 2(10), 2057-2064. https://doi.org/10.1021/nn800395t
Ajima, Kumiko ; Murakami, Tatsuya ; Mizoguchi, Yoshikazu ; Tsuchida, Kunihiro ; Ichihashi, Toshinari ; Iijima, Sumio ; Yudasaka, Masako. / Enhancement of in vivo anticancer effects of cisplatin by incorporation inside single-wall carbon nanohorns. In: ACS Nano. 2008 ; Vol. 2, No. 10. pp. 2057-2064.
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Ajima, K, Murakami, T, Mizoguchi, Y, Tsuchida, K, Ichihashi, T, Iijima, S & Yudasaka, M 2008, 'Enhancement of in vivo anticancer effects of cisplatin by incorporation inside single-wall carbon nanohorns', ACS Nano, vol. 2, no. 10, pp. 2057-2064. https://doi.org/10.1021/nn800395t

Enhancement of in vivo anticancer effects of cisplatin by incorporation inside single-wall carbon nanohorns. / Ajima, Kumiko; Murakami, Tatsuya; Mizoguchi, Yoshikazu; Tsuchida, Kunihiro; Ichihashi, Toshinari; Iijima, Sumio; Yudasaka, Masako.

In: ACS Nano, Vol. 2, No. 10, 01.10.2008, p. 2057-2064.

Research output: Contribution to journalArticle

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AU - Iijima, Sumio

AU - Yudasaka, Masako

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