Abstract
We isolated genes for the opioid receptor homologue MOR-C, namely nociceptin receptor (designated alternatively as orphanin FQ receptor) and generated nociceptin receptor-knockout mice. Previously, we have reported that the nociceptin system appears to participate in the regulation of the auditory system. However, the behavior of the nociceptin receptor-knockout mice has yet to be fully characterized. In the present study, we investigated changes in several behavioral performances in mice which lack nociceptin receptor. Nociceptive thresholds of nociceptin receptor-knockout mice were unchanged in the hot-plate and electric foot-shock tests as well as tail- flick and acetic acid-induced writhing tests compared to those of wild-type mice. The nociceptin receptor-knockout mice did not show any behavioral changes in the elevated plus-maze task. Surprisingly, in the water-finding test, the nociceptin receptor-knockout mice showed an enhanced retention of spatial attention (latent learning) compared to wild-type mice. In a biochemical study, dopamine content in the frontal cortex was lower in nociceptin receptor-knockout mice than wild-type mice. These results suggest that nociceptin receptor plays an important role in spatial attention by regulating the dopaminergic system in the brain.
| Original language | English |
|---|---|
| Pages (from-to) | 236-240 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 783 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 02-09-1998 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Molecular Biology
- Developmental Biology
- Clinical Neurology
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Enhancement of spatial attention in nociceptin/orphanin FQ receptor- knockout mice. / Mamiya, Takayoshi; Noda, Yukihiro; Nishi, Miyuki; Takeshima, Hiroshi; Nabeshima, Toshitaka.
In: Brain Research, Vol. 783, No. 2, 02.09.1998, p. 236-240.Research output: Contribution to journal › Article
TY - JOUR
T1 - Enhancement of spatial attention in nociceptin/orphanin FQ receptor- knockout mice
AU - Mamiya, Takayoshi
AU - Noda, Yukihiro
AU - Nishi, Miyuki
AU - Takeshima, Hiroshi
AU - Nabeshima, Toshitaka
PY - 1998/9/2
Y1 - 1998/9/2
N2 - We isolated genes for the opioid receptor homologue MOR-C, namely nociceptin receptor (designated alternatively as orphanin FQ receptor) and generated nociceptin receptor-knockout mice. Previously, we have reported that the nociceptin system appears to participate in the regulation of the auditory system. However, the behavior of the nociceptin receptor-knockout mice has yet to be fully characterized. In the present study, we investigated changes in several behavioral performances in mice which lack nociceptin receptor. Nociceptive thresholds of nociceptin receptor-knockout mice were unchanged in the hot-plate and electric foot-shock tests as well as tail- flick and acetic acid-induced writhing tests compared to those of wild-type mice. The nociceptin receptor-knockout mice did not show any behavioral changes in the elevated plus-maze task. Surprisingly, in the water-finding test, the nociceptin receptor-knockout mice showed an enhanced retention of spatial attention (latent learning) compared to wild-type mice. In a biochemical study, dopamine content in the frontal cortex was lower in nociceptin receptor-knockout mice than wild-type mice. These results suggest that nociceptin receptor plays an important role in spatial attention by regulating the dopaminergic system in the brain.
AB - We isolated genes for the opioid receptor homologue MOR-C, namely nociceptin receptor (designated alternatively as orphanin FQ receptor) and generated nociceptin receptor-knockout mice. Previously, we have reported that the nociceptin system appears to participate in the regulation of the auditory system. However, the behavior of the nociceptin receptor-knockout mice has yet to be fully characterized. In the present study, we investigated changes in several behavioral performances in mice which lack nociceptin receptor. Nociceptive thresholds of nociceptin receptor-knockout mice were unchanged in the hot-plate and electric foot-shock tests as well as tail- flick and acetic acid-induced writhing tests compared to those of wild-type mice. The nociceptin receptor-knockout mice did not show any behavioral changes in the elevated plus-maze task. Surprisingly, in the water-finding test, the nociceptin receptor-knockout mice showed an enhanced retention of spatial attention (latent learning) compared to wild-type mice. In a biochemical study, dopamine content in the frontal cortex was lower in nociceptin receptor-knockout mice than wild-type mice. These results suggest that nociceptin receptor plays an important role in spatial attention by regulating the dopaminergic system in the brain.
UR - http://www.scopus.com/inward/record.url?scp=0031912743&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031912743&partnerID=8YFLogxK
U2 - 10.1016/S0006-8993(97)01406-6
DO - 10.1016/S0006-8993(97)01406-6
M3 - Article
C2 - 9507149
AN - SCOPUS:0031912743
VL - 783
SP - 236
EP - 240
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2
ER -