Enhancement of spatial attention in nociceptin/orphanin FQ receptor- knockout mice

Takayoshi Mamiya, Yukihiro Noda, Miyuki Nishi, Hiroshi Takeshima, Toshitaka Nabeshima

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

We isolated genes for the opioid receptor homologue MOR-C, namely nociceptin receptor (designated alternatively as orphanin FQ receptor) and generated nociceptin receptor-knockout mice. Previously, we have reported that the nociceptin system appears to participate in the regulation of the auditory system. However, the behavior of the nociceptin receptor-knockout mice has yet to be fully characterized. In the present study, we investigated changes in several behavioral performances in mice which lack nociceptin receptor. Nociceptive thresholds of nociceptin receptor-knockout mice were unchanged in the hot-plate and electric foot-shock tests as well as tail- flick and acetic acid-induced writhing tests compared to those of wild-type mice. The nociceptin receptor-knockout mice did not show any behavioral changes in the elevated plus-maze task. Surprisingly, in the water-finding test, the nociceptin receptor-knockout mice showed an enhanced retention of spatial attention (latent learning) compared to wild-type mice. In a biochemical study, dopamine content in the frontal cortex was lower in nociceptin receptor-knockout mice than wild-type mice. These results suggest that nociceptin receptor plays an important role in spatial attention by regulating the dopaminergic system in the brain.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalBrain Research
Volume783
Issue number2
DOIs
Publication statusPublished - 02-09-1998
Externally publishedYes

Fingerprint

Knockout Mice
nociceptin receptor
nociceptin
Opioid Receptors
Frontal Lobe
Acetic Acid
Tail
Foot
Shock
Dopamine
Learning
Water
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

Cite this

Mamiya, Takayoshi ; Noda, Yukihiro ; Nishi, Miyuki ; Takeshima, Hiroshi ; Nabeshima, Toshitaka. / Enhancement of spatial attention in nociceptin/orphanin FQ receptor- knockout mice. In: Brain Research. 1998 ; Vol. 783, No. 2. pp. 236-240.
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Enhancement of spatial attention in nociceptin/orphanin FQ receptor- knockout mice. / Mamiya, Takayoshi; Noda, Yukihiro; Nishi, Miyuki; Takeshima, Hiroshi; Nabeshima, Toshitaka.

In: Brain Research, Vol. 783, No. 2, 02.09.1998, p. 236-240.

Research output: Contribution to journalArticle

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