ENOS genotype modifies the effect of leisure-time physical activity on serum triglyceride levels in a Japanese population

Takahiro Higashibata, Nobuyuki Hamajima, Mariko Naito, Sayo Kawai, Guang Yin, Sadao Suzuki, Yoshikuni Kita, Hideshi Niimura, Takeshi Imaizumi, Keizo Ohnaka, Kokichi Arisawa, Masako Shigeta, Hidemi Ito, Haruo Mikami, Michiaki Kubo, Hideo Tanaka, Kenji Wakai

Research output: Contribution to journalArticle

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Abstract

Background: Nitric oxide is a key molecule not only in the cardiovascular system, but also in the metabolic-endocrine system. The purpose of this study was to examine possible associations of the NOS3 T-786C polymorphism (rs2070744) with serum lipid levels on the basis of lifestyle factors for tailoring prevention of dyslipidemia. Methods. For this cross-sectional study, a total of 2226 subjects aged 35 to 69 years (1084 men and 1142 women) were selected from Japanese participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. They were recruited in eight areas throughout Japan between February 2004 and November 2008. Results: In a stratified analysis by leisure-time physical activity, the likelihood of hypertriglyceridemia (serum triglyceride levels ≥ 150 mg/dL) among subjects with the C allele was significantly lower than those without it in the active group (OR = 0.43, 95% CI = 0.22-0.84 in the fasting group), but not in the sedentary group. A gene-environment interaction between the T-786C polymorphism and leisure-time physical activity for hypertriglyceridemia was significant (P = 0.007 in the fasting group). Additionally, serum triglyceride levels (mean ± SD) across leisure-time physical activity classes decreased significantly only in the TC + CC genotype group (111 ± 60 mg/dL for sedentary, 95 ± 48 mg/dL for moderately active, 88 ± 44 mg/dL for very active, P for trend = 0.008 in the fasting group), but not in the TT genotype group. Total cholesterol, high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol levels had no significant association with the polymorphism. Conclusions: This study suggests that the NOS3 T-786C polymorphism modifies the effect of leisure-time physical activity on serum triglyceride levels.

Original languageEnglish
Article number150
JournalLipids in Health and Disease
Volume11
DOIs
Publication statusPublished - 07-11-2012

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Leisure Activities
Polymorphism
Triglycerides
Genotype
Exercise
Fasting
Hypertriglyceridemia
Serum
Population
Japan
Cardiovascular system
Gene-Environment Interaction
Endocrine System
Cholesterol
Dyslipidemias
Cardiovascular System
HDL Cholesterol
Life Style
Nitric Oxide
Cohort Studies

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Higashibata, Takahiro ; Hamajima, Nobuyuki ; Naito, Mariko ; Kawai, Sayo ; Yin, Guang ; Suzuki, Sadao ; Kita, Yoshikuni ; Niimura, Hideshi ; Imaizumi, Takeshi ; Ohnaka, Keizo ; Arisawa, Kokichi ; Shigeta, Masako ; Ito, Hidemi ; Mikami, Haruo ; Kubo, Michiaki ; Tanaka, Hideo ; Wakai, Kenji. / ENOS genotype modifies the effect of leisure-time physical activity on serum triglyceride levels in a Japanese population. In: Lipids in Health and Disease. 2012 ; Vol. 11.
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title = "ENOS genotype modifies the effect of leisure-time physical activity on serum triglyceride levels in a Japanese population",
abstract = "Background: Nitric oxide is a key molecule not only in the cardiovascular system, but also in the metabolic-endocrine system. The purpose of this study was to examine possible associations of the NOS3 T-786C polymorphism (rs2070744) with serum lipid levels on the basis of lifestyle factors for tailoring prevention of dyslipidemia. Methods. For this cross-sectional study, a total of 2226 subjects aged 35 to 69 years (1084 men and 1142 women) were selected from Japanese participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. They were recruited in eight areas throughout Japan between February 2004 and November 2008. Results: In a stratified analysis by leisure-time physical activity, the likelihood of hypertriglyceridemia (serum triglyceride levels ≥ 150 mg/dL) among subjects with the C allele was significantly lower than those without it in the active group (OR = 0.43, 95{\%} CI = 0.22-0.84 in the fasting group), but not in the sedentary group. A gene-environment interaction between the T-786C polymorphism and leisure-time physical activity for hypertriglyceridemia was significant (P = 0.007 in the fasting group). Additionally, serum triglyceride levels (mean ± SD) across leisure-time physical activity classes decreased significantly only in the TC + CC genotype group (111 ± 60 mg/dL for sedentary, 95 ± 48 mg/dL for moderately active, 88 ± 44 mg/dL for very active, P for trend = 0.008 in the fasting group), but not in the TT genotype group. Total cholesterol, high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol levels had no significant association with the polymorphism. Conclusions: This study suggests that the NOS3 T-786C polymorphism modifies the effect of leisure-time physical activity on serum triglyceride levels.",
author = "Takahiro Higashibata and Nobuyuki Hamajima and Mariko Naito and Sayo Kawai and Guang Yin and Sadao Suzuki and Yoshikuni Kita and Hideshi Niimura and Takeshi Imaizumi and Keizo Ohnaka and Kokichi Arisawa and Masako Shigeta and Hidemi Ito and Haruo Mikami and Michiaki Kubo and Hideo Tanaka and Kenji Wakai",
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Higashibata, T, Hamajima, N, Naito, M, Kawai, S, Yin, G, Suzuki, S, Kita, Y, Niimura, H, Imaizumi, T, Ohnaka, K, Arisawa, K, Shigeta, M, Ito, H, Mikami, H, Kubo, M, Tanaka, H & Wakai, K 2012, 'ENOS genotype modifies the effect of leisure-time physical activity on serum triglyceride levels in a Japanese population', Lipids in Health and Disease, vol. 11, 150. https://doi.org/10.1186/1476-511X-11-150

ENOS genotype modifies the effect of leisure-time physical activity on serum triglyceride levels in a Japanese population. / Higashibata, Takahiro; Hamajima, Nobuyuki; Naito, Mariko; Kawai, Sayo; Yin, Guang; Suzuki, Sadao; Kita, Yoshikuni; Niimura, Hideshi; Imaizumi, Takeshi; Ohnaka, Keizo; Arisawa, Kokichi; Shigeta, Masako; Ito, Hidemi; Mikami, Haruo; Kubo, Michiaki; Tanaka, Hideo; Wakai, Kenji.

In: Lipids in Health and Disease, Vol. 11, 150, 07.11.2012.

Research output: Contribution to journalArticle

TY - JOUR

T1 - ENOS genotype modifies the effect of leisure-time physical activity on serum triglyceride levels in a Japanese population

AU - Higashibata, Takahiro

AU - Hamajima, Nobuyuki

AU - Naito, Mariko

AU - Kawai, Sayo

AU - Yin, Guang

AU - Suzuki, Sadao

AU - Kita, Yoshikuni

AU - Niimura, Hideshi

AU - Imaizumi, Takeshi

AU - Ohnaka, Keizo

AU - Arisawa, Kokichi

AU - Shigeta, Masako

AU - Ito, Hidemi

AU - Mikami, Haruo

AU - Kubo, Michiaki

AU - Tanaka, Hideo

AU - Wakai, Kenji

PY - 2012/11/7

Y1 - 2012/11/7

N2 - Background: Nitric oxide is a key molecule not only in the cardiovascular system, but also in the metabolic-endocrine system. The purpose of this study was to examine possible associations of the NOS3 T-786C polymorphism (rs2070744) with serum lipid levels on the basis of lifestyle factors for tailoring prevention of dyslipidemia. Methods. For this cross-sectional study, a total of 2226 subjects aged 35 to 69 years (1084 men and 1142 women) were selected from Japanese participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. They were recruited in eight areas throughout Japan between February 2004 and November 2008. Results: In a stratified analysis by leisure-time physical activity, the likelihood of hypertriglyceridemia (serum triglyceride levels ≥ 150 mg/dL) among subjects with the C allele was significantly lower than those without it in the active group (OR = 0.43, 95% CI = 0.22-0.84 in the fasting group), but not in the sedentary group. A gene-environment interaction between the T-786C polymorphism and leisure-time physical activity for hypertriglyceridemia was significant (P = 0.007 in the fasting group). Additionally, serum triglyceride levels (mean ± SD) across leisure-time physical activity classes decreased significantly only in the TC + CC genotype group (111 ± 60 mg/dL for sedentary, 95 ± 48 mg/dL for moderately active, 88 ± 44 mg/dL for very active, P for trend = 0.008 in the fasting group), but not in the TT genotype group. Total cholesterol, high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol levels had no significant association with the polymorphism. Conclusions: This study suggests that the NOS3 T-786C polymorphism modifies the effect of leisure-time physical activity on serum triglyceride levels.

AB - Background: Nitric oxide is a key molecule not only in the cardiovascular system, but also in the metabolic-endocrine system. The purpose of this study was to examine possible associations of the NOS3 T-786C polymorphism (rs2070744) with serum lipid levels on the basis of lifestyle factors for tailoring prevention of dyslipidemia. Methods. For this cross-sectional study, a total of 2226 subjects aged 35 to 69 years (1084 men and 1142 women) were selected from Japanese participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. They were recruited in eight areas throughout Japan between February 2004 and November 2008. Results: In a stratified analysis by leisure-time physical activity, the likelihood of hypertriglyceridemia (serum triglyceride levels ≥ 150 mg/dL) among subjects with the C allele was significantly lower than those without it in the active group (OR = 0.43, 95% CI = 0.22-0.84 in the fasting group), but not in the sedentary group. A gene-environment interaction between the T-786C polymorphism and leisure-time physical activity for hypertriglyceridemia was significant (P = 0.007 in the fasting group). Additionally, serum triglyceride levels (mean ± SD) across leisure-time physical activity classes decreased significantly only in the TC + CC genotype group (111 ± 60 mg/dL for sedentary, 95 ± 48 mg/dL for moderately active, 88 ± 44 mg/dL for very active, P for trend = 0.008 in the fasting group), but not in the TT genotype group. Total cholesterol, high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol levels had no significant association with the polymorphism. Conclusions: This study suggests that the NOS3 T-786C polymorphism modifies the effect of leisure-time physical activity on serum triglyceride levels.

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