Enteral nutrition decreases hospitalization rate in patients with Crohn's disease

Osamu Watanabe, Takafumi Ando, Kazuhiro Ishiguro, Hironao Takahashi, Daisuke Ishikawa, Nobuyuki Miyake, Tsuyoshi Kato, Satoshi Hibi, Shunya Mimura, Masanao Nakamura, Ryoji Miyahara, Naoki Omiya, Yasumasa Niwa, Hidemi Goto

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background and Aims: Crohn's disease (CD) is a chronic inflammatory bowel disease with relapse and remission. CD patients are admitted to hospital when bowel inflammation flares up severely, which lowers their quality of life. Enteral nutrition (EN) with an elemental diet plays an important role in the treatment for CD patients in Japan, because of its few adverse effects, and it is thought to be effective in maintaining remission. We investigated the effectiveness of EN with an elemental diet with regard to the avoidance of hospitalization. Methods: A total of 268 patients with CD who visited hospital from 2003-2008 were enrolled. The relationship between the caloric content of an elemental diet and hospitalization as an end-point was examined retrospectively using Cox regression analysis. Cumulative non-hospitalization rates were calculated by the Kaplan-Meier method. Results: Of the 268 patients, 155 received an elemental diet providing 900 kcal/day or more. Among 237 patients with ileal involvement, 135 patients receiving an elemental diet providing 900 kcal/day or more showed a statistically significant improvement in cumulative non-hospitalization rate. Among 31 patients without ileal involvement, in contrast, the cumulative non-hospitalization rate did not differ among those receiving an elemental diet of less or more than 900 kcal/day. Conclusion: The use of an elemental diet of 900 kcal/day may be effective in avoiding hospitalization in CD patients with ileal lesions. This diet may be useful in improving the long-term convalescence of these patients.

Original languageEnglish
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume25
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 01-01-2010
Externally publishedYes

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Enteral Nutrition
Formulated Food
Crohn Disease
Hospitalization
Inflammatory Bowel Diseases
Japan
Regression Analysis
Quality of Life
Diet
Inflammation
Recurrence

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Watanabe, Osamu ; Ando, Takafumi ; Ishiguro, Kazuhiro ; Takahashi, Hironao ; Ishikawa, Daisuke ; Miyake, Nobuyuki ; Kato, Tsuyoshi ; Hibi, Satoshi ; Mimura, Shunya ; Nakamura, Masanao ; Miyahara, Ryoji ; Omiya, Naoki ; Niwa, Yasumasa ; Goto, Hidemi. / Enteral nutrition decreases hospitalization rate in patients with Crohn's disease. In: Journal of Gastroenterology and Hepatology (Australia). 2010 ; Vol. 25, No. SUPPL. 1.
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abstract = "Background and Aims: Crohn's disease (CD) is a chronic inflammatory bowel disease with relapse and remission. CD patients are admitted to hospital when bowel inflammation flares up severely, which lowers their quality of life. Enteral nutrition (EN) with an elemental diet plays an important role in the treatment for CD patients in Japan, because of its few adverse effects, and it is thought to be effective in maintaining remission. We investigated the effectiveness of EN with an elemental diet with regard to the avoidance of hospitalization. Methods: A total of 268 patients with CD who visited hospital from 2003-2008 were enrolled. The relationship between the caloric content of an elemental diet and hospitalization as an end-point was examined retrospectively using Cox regression analysis. Cumulative non-hospitalization rates were calculated by the Kaplan-Meier method. Results: Of the 268 patients, 155 received an elemental diet providing 900 kcal/day or more. Among 237 patients with ileal involvement, 135 patients receiving an elemental diet providing 900 kcal/day or more showed a statistically significant improvement in cumulative non-hospitalization rate. Among 31 patients without ileal involvement, in contrast, the cumulative non-hospitalization rate did not differ among those receiving an elemental diet of less or more than 900 kcal/day. Conclusion: The use of an elemental diet of 900 kcal/day may be effective in avoiding hospitalization in CD patients with ileal lesions. This diet may be useful in improving the long-term convalescence of these patients.",
author = "Osamu Watanabe and Takafumi Ando and Kazuhiro Ishiguro and Hironao Takahashi and Daisuke Ishikawa and Nobuyuki Miyake and Tsuyoshi Kato and Satoshi Hibi and Shunya Mimura and Masanao Nakamura and Ryoji Miyahara and Naoki Omiya and Yasumasa Niwa and Hidemi Goto",
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Watanabe, O, Ando, T, Ishiguro, K, Takahashi, H, Ishikawa, D, Miyake, N, Kato, T, Hibi, S, Mimura, S, Nakamura, M, Miyahara, R, Omiya, N, Niwa, Y & Goto, H 2010, 'Enteral nutrition decreases hospitalization rate in patients with Crohn's disease', Journal of Gastroenterology and Hepatology (Australia), vol. 25, no. SUPPL. 1. https://doi.org/10.1111/j.1440-1746.2010.06296.x

Enteral nutrition decreases hospitalization rate in patients with Crohn's disease. / Watanabe, Osamu; Ando, Takafumi; Ishiguro, Kazuhiro; Takahashi, Hironao; Ishikawa, Daisuke; Miyake, Nobuyuki; Kato, Tsuyoshi; Hibi, Satoshi; Mimura, Shunya; Nakamura, Masanao; Miyahara, Ryoji; Omiya, Naoki; Niwa, Yasumasa; Goto, Hidemi.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 25, No. SUPPL. 1, 01.01.2010.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Enteral nutrition decreases hospitalization rate in patients with Crohn's disease

AU - Watanabe, Osamu

AU - Ando, Takafumi

AU - Ishiguro, Kazuhiro

AU - Takahashi, Hironao

AU - Ishikawa, Daisuke

AU - Miyake, Nobuyuki

AU - Kato, Tsuyoshi

AU - Hibi, Satoshi

AU - Mimura, Shunya

AU - Nakamura, Masanao

AU - Miyahara, Ryoji

AU - Omiya, Naoki

AU - Niwa, Yasumasa

AU - Goto, Hidemi

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Background and Aims: Crohn's disease (CD) is a chronic inflammatory bowel disease with relapse and remission. CD patients are admitted to hospital when bowel inflammation flares up severely, which lowers their quality of life. Enteral nutrition (EN) with an elemental diet plays an important role in the treatment for CD patients in Japan, because of its few adverse effects, and it is thought to be effective in maintaining remission. We investigated the effectiveness of EN with an elemental diet with regard to the avoidance of hospitalization. Methods: A total of 268 patients with CD who visited hospital from 2003-2008 were enrolled. The relationship between the caloric content of an elemental diet and hospitalization as an end-point was examined retrospectively using Cox regression analysis. Cumulative non-hospitalization rates were calculated by the Kaplan-Meier method. Results: Of the 268 patients, 155 received an elemental diet providing 900 kcal/day or more. Among 237 patients with ileal involvement, 135 patients receiving an elemental diet providing 900 kcal/day or more showed a statistically significant improvement in cumulative non-hospitalization rate. Among 31 patients without ileal involvement, in contrast, the cumulative non-hospitalization rate did not differ among those receiving an elemental diet of less or more than 900 kcal/day. Conclusion: The use of an elemental diet of 900 kcal/day may be effective in avoiding hospitalization in CD patients with ileal lesions. This diet may be useful in improving the long-term convalescence of these patients.

AB - Background and Aims: Crohn's disease (CD) is a chronic inflammatory bowel disease with relapse and remission. CD patients are admitted to hospital when bowel inflammation flares up severely, which lowers their quality of life. Enteral nutrition (EN) with an elemental diet plays an important role in the treatment for CD patients in Japan, because of its few adverse effects, and it is thought to be effective in maintaining remission. We investigated the effectiveness of EN with an elemental diet with regard to the avoidance of hospitalization. Methods: A total of 268 patients with CD who visited hospital from 2003-2008 were enrolled. The relationship between the caloric content of an elemental diet and hospitalization as an end-point was examined retrospectively using Cox regression analysis. Cumulative non-hospitalization rates were calculated by the Kaplan-Meier method. Results: Of the 268 patients, 155 received an elemental diet providing 900 kcal/day or more. Among 237 patients with ileal involvement, 135 patients receiving an elemental diet providing 900 kcal/day or more showed a statistically significant improvement in cumulative non-hospitalization rate. Among 31 patients without ileal involvement, in contrast, the cumulative non-hospitalization rate did not differ among those receiving an elemental diet of less or more than 900 kcal/day. Conclusion: The use of an elemental diet of 900 kcal/day may be effective in avoiding hospitalization in CD patients with ileal lesions. This diet may be useful in improving the long-term convalescence of these patients.

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