Environmental enrichment alters gene expression of steroidogenic enzymes in the rat hippocampus

Eiji Munetsuna; Minoru Hattori; Yuya Sakimoto; Atsuhiko Ishida; Shogo Sakata; Yasushi Hojo; Suguru Kawato; Takeshi Yamazaki

doi:10.1016/j.ygcen.2010.12.007

Environmental enrichment alters gene expression of steroidogenic enzymes in the rat hippocampus

Eiji Munetsuna
, Minoru Hattori
, Yuya Sakimoto
, Atsuhiko Ishida
, Shogo Sakata
, Yasushi Hojo
, Suguru Kawato
, Takeshi Yamazaki

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Neuroactive steroids are synthesized in the central and peripheral nervous systems. The purpose of this study was to analyze the effects of environmental enrichment on neuroactive steroidogenesis in the rat hippocampus. Environmental enrichment rats were housed in a group of nine in a large cage and three groups of pair-housed rats were housed in a standard cage for 8. weeks. The levels of mRNAs for steroidogenic enzymes and proteins in hippocampus were quantified by real-time RT-PCR. Environmental enrichment increased the mRNA expression levels of 5α-reductase-1 and 3α-hydroxysteroid dehydrogenase, which catalyze synthesis of allopregnanolone from progesterone. Hence, environmental enrichment appears to affect allopregnanolone synthesis.

Original language	English
Pages (from-to)	28-32
Number of pages	5
Journal	General and Comparative Endocrinology
Volume	171
Issue number	1
DOIs	https://doi.org/10.1016/j.ygcen.2010.12.007
Publication status	Published - 01-03-2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Animal Science and Zoology
Endocrinology

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10.1016/j.ygcen.2010.12.007

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abstract = "Neuroactive steroids are synthesized in the central and peripheral nervous systems. The purpose of this study was to analyze the effects of environmental enrichment on neuroactive steroidogenesis in the rat hippocampus. Environmental enrichment rats were housed in a group of nine in a large cage and three groups of pair-housed rats were housed in a standard cage for 8. weeks. The levels of mRNAs for steroidogenic enzymes and proteins in hippocampus were quantified by real-time RT-PCR. Environmental enrichment increased the mRNA expression levels of 5α-reductase-1 and 3α-hydroxysteroid dehydrogenase, which catalyze synthesis of allopregnanolone from progesterone. Hence, environmental enrichment appears to affect allopregnanolone synthesis.",

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AU - Munetsuna, Eiji

AU - Hattori, Minoru

AU - Sakimoto, Yuya

AU - Ishida, Atsuhiko

AU - Sakata, Shogo

AU - Hojo, Yasushi

AU - Kawato, Suguru

AU - Yamazaki, Takeshi

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Neuroactive steroids are synthesized in the central and peripheral nervous systems. The purpose of this study was to analyze the effects of environmental enrichment on neuroactive steroidogenesis in the rat hippocampus. Environmental enrichment rats were housed in a group of nine in a large cage and three groups of pair-housed rats were housed in a standard cage for 8. weeks. The levels of mRNAs for steroidogenic enzymes and proteins in hippocampus were quantified by real-time RT-PCR. Environmental enrichment increased the mRNA expression levels of 5α-reductase-1 and 3α-hydroxysteroid dehydrogenase, which catalyze synthesis of allopregnanolone from progesterone. Hence, environmental enrichment appears to affect allopregnanolone synthesis.

AB - Neuroactive steroids are synthesized in the central and peripheral nervous systems. The purpose of this study was to analyze the effects of environmental enrichment on neuroactive steroidogenesis in the rat hippocampus. Environmental enrichment rats were housed in a group of nine in a large cage and three groups of pair-housed rats were housed in a standard cage for 8. weeks. The levels of mRNAs for steroidogenic enzymes and proteins in hippocampus were quantified by real-time RT-PCR. Environmental enrichment increased the mRNA expression levels of 5α-reductase-1 and 3α-hydroxysteroid dehydrogenase, which catalyze synthesis of allopregnanolone from progesterone. Hence, environmental enrichment appears to affect allopregnanolone synthesis.

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Environmental enrichment alters gene expression of steroidogenic enzymes in the rat hippocampus

Abstract

All Science Journal Classification (ASJC) codes

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