TY - JOUR
T1 - Enzyme‐linked immunosorbent assay for detection of IgG antibody to human herpesvirus 6
AU - Asano, Yoshizo
AU - Yoshikawa, Tetsushi
AU - Suga, Sadao
AU - Yazaki, Takehiko
AU - Ozaki, Takao
AU - Saito, Yumiko
AU - Hatano, Yasuko
AU - Takahashi, Masayoshi
PY - 1990/10
Y1 - 1990/10
N2 - A lysate of human herpesvirus 6 (HHV‐6)‐infected cord blood mononuclear cells was used as antigen for enzyme‐linked immunosorbent assay for the detection of lgG antibody to HHV‐6. Antibody responses after exanthem subitum were well correlated with clinical recovery from the disease and the level of antibody activities was well correlated with indirect immunofluorescence assay and the neutralization test. Seroconversion to other human herpesvirus, including cytomegalovirus, was not observed in infants with exanthem subitum. All of the infants had by the age of 1 month antibodies to HHV‐6, which decreased with age to the lowest level at the age of 3 to 6 months and then increased and reached the maximum level by 1 to 2 years of age. After 3 years of age, the prevalence was almost stable.
AB - A lysate of human herpesvirus 6 (HHV‐6)‐infected cord blood mononuclear cells was used as antigen for enzyme‐linked immunosorbent assay for the detection of lgG antibody to HHV‐6. Antibody responses after exanthem subitum were well correlated with clinical recovery from the disease and the level of antibody activities was well correlated with indirect immunofluorescence assay and the neutralization test. Seroconversion to other human herpesvirus, including cytomegalovirus, was not observed in infants with exanthem subitum. All of the infants had by the age of 1 month antibodies to HHV‐6, which decreased with age to the lowest level at the age of 3 to 6 months and then increased and reached the maximum level by 1 to 2 years of age. After 3 years of age, the prevalence was almost stable.
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U2 - 10.1002/jmv.1890320209
DO - 10.1002/jmv.1890320209
M3 - Article
C2 - 2177773
AN - SCOPUS:0025633221
SN - 0146-6615
VL - 32
SP - 119
EP - 123
JO - Journal of Medical Virology
JF - Journal of Medical Virology
IS - 2
ER -