TY - JOUR
T1 - Epicardial fat volume correlates with severity of coronary artery disease in nonobese patients
AU - Okada, Koji
AU - Ohshima, Satoru
AU - Isobe, Satoshi
AU - Harada, Ken
AU - Hirashiki, Akihiro
AU - Funahashi, Hidehito
AU - Arai, Kosuke
AU - Hayashi, Daisuke
AU - Hayashi, Mutsuharu
AU - Ishii, Hideki
AU - Murohara, Toyoaki
PY - 2014/5
Y1 - 2014/5
N2 - Objective: It has been reported that epicardial adipose tissue could locally modulate the coronary artery functions through secretion of proinflammatory and anti-inflammatory cytokines. Epicardial fat tissue is further implicated in the pathogenesis of coronary artery disease (CAD) because of its proximity to the adventitia of the major epicardial coronary arteries. We investigated the relationship between epicardial fat volume (EFV) and severity of CAD in nonobese patients using 64-slice multidetector computed tomography (MDCT). Methods: One hundred and forty nonobese patients (BMI <25 kg/m 2) were enrolled. EFV and visceral fat area were measured by MDCT. Patients were classified according to the plaque components (noncalcified, mixed and calcified) and severity of CAD. Inflammatory biomarkers were also measured, and compared with each CT parameter. Results: EFV was significantly correlated with the extent or severity of CAD. Patients with noncalcified or mixed plaque had a greater EFV than those with calcified plaque. Log-transferred high sensitivity C-reactive protein (CRP) was significantly correlated with EFV (r = 0.24, P = 0.04). Adiponectin level was significantly inversely correlated with visceral fat area (r = 0.38, P = 0.0001). Conclusion: Increased EFV is associated with more severe CAD and noncalcified or mixed coronary plaques in nonobese patients.
AB - Objective: It has been reported that epicardial adipose tissue could locally modulate the coronary artery functions through secretion of proinflammatory and anti-inflammatory cytokines. Epicardial fat tissue is further implicated in the pathogenesis of coronary artery disease (CAD) because of its proximity to the adventitia of the major epicardial coronary arteries. We investigated the relationship between epicardial fat volume (EFV) and severity of CAD in nonobese patients using 64-slice multidetector computed tomography (MDCT). Methods: One hundred and forty nonobese patients (BMI <25 kg/m 2) were enrolled. EFV and visceral fat area were measured by MDCT. Patients were classified according to the plaque components (noncalcified, mixed and calcified) and severity of CAD. Inflammatory biomarkers were also measured, and compared with each CT parameter. Results: EFV was significantly correlated with the extent or severity of CAD. Patients with noncalcified or mixed plaque had a greater EFV than those with calcified plaque. Log-transferred high sensitivity C-reactive protein (CRP) was significantly correlated with EFV (r = 0.24, P = 0.04). Adiponectin level was significantly inversely correlated with visceral fat area (r = 0.38, P = 0.0001). Conclusion: Increased EFV is associated with more severe CAD and noncalcified or mixed coronary plaques in nonobese patients.
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U2 - 10.2459/JCM.0b013e32836094da
DO - 10.2459/JCM.0b013e32836094da
M3 - Article
C2 - 23549277
AN - SCOPUS:84899983202
SN - 1558-2027
VL - 15
SP - 384
EP - 390
JO - Journal of Cardiovascular Medicine
JF - Journal of Cardiovascular Medicine
IS - 5
ER -