TY - JOUR
T1 - Epidemics of drug-resistant bacterial infections observed in infectious disease surveillance in Japan, 2001-2005
AU - Izumida, Michiko
AU - Nagai, Masaki
AU - Ohta, Akiko
AU - Hashimoto, Shuji
AU - Kawado, Miyuki
AU - Murakami, Yoshitaka
AU - Tada, Yuki
AU - Shigematsu, Mika
AU - Yasui, Yoshinori
AU - Taniguchi, Kiyosu
N1 - Funding Information:
The authors acknowledge ESRF for provision of synchrotron radiation facilities and we would like to thank Samuel TARDIF for assistance in using the French CRG-BM32 beamline. This work has been partially supported by the LabEx Minos ANR-10-LABX-55-01. The Silicon Technologies Division (CEA-LETI) is gratefully acknowledged, for equipment access and sample manufacturing.
PY - 2007/12
Y1 - 2007/12
N2 - Background: Drug-resistant bacteria have been increasing together with advancement of antimicrobial chemotherapy in recent years. In Japan, the target diseases in the National Epidemiological Surveillance of Infectious Diseases (NESID) include some drug-resistant bacterial infections. Methods: We used the data in the NESID in Japan, 2001-2005. Target diseases were methicillin-resistant Staphylocoocus aureus (MRSA), penicillin-resistant Streptocoocus pneumoniae (PRSP) and multi-drug-resistant Pseudomonas aeruginosa (MDRPA) infections. The numbers of patients reported by sentinel hospitals (about 500) on a monthly basis were observed. Results: The numbers of patients per month per sentinel hospital of 2001-2005 were 3.37-3.98 in MRSA, 6.96-1.19 in PRSP, and 0.11-0.13 in MDRPA infections. The sex ratios (male/female) of patients were 1.69-l.82, 1.34-1.43, and 1.71-2.52, respectively. More than 50% of all patients were adults aged 70 years or older in MRSA and MDRPA infections, but more than 60% were children under 10 years in PRSP infections. The number of patients per sentinel hospital in MRSA infections showed little variation between months but evidenced a large variation in PRSP and MDRPA infections. The annual trend in the number of patients per sentinel hospital was increasing significantly for the 5-year period in MRSA and PRSP infections, but not in MDRPA infections. Conclusions: We revealed sex-age distributions of the patients reported to NESID in Japan, 2001-2005. An increasing incidence of MRSA and PRSP infections and monthly variation in PRSP and MDRPA infections were observed for the 5-year period. Extended observation would be necessary to confirm these trends and variations.
AB - Background: Drug-resistant bacteria have been increasing together with advancement of antimicrobial chemotherapy in recent years. In Japan, the target diseases in the National Epidemiological Surveillance of Infectious Diseases (NESID) include some drug-resistant bacterial infections. Methods: We used the data in the NESID in Japan, 2001-2005. Target diseases were methicillin-resistant Staphylocoocus aureus (MRSA), penicillin-resistant Streptocoocus pneumoniae (PRSP) and multi-drug-resistant Pseudomonas aeruginosa (MDRPA) infections. The numbers of patients reported by sentinel hospitals (about 500) on a monthly basis were observed. Results: The numbers of patients per month per sentinel hospital of 2001-2005 were 3.37-3.98 in MRSA, 6.96-1.19 in PRSP, and 0.11-0.13 in MDRPA infections. The sex ratios (male/female) of patients were 1.69-l.82, 1.34-1.43, and 1.71-2.52, respectively. More than 50% of all patients were adults aged 70 years or older in MRSA and MDRPA infections, but more than 60% were children under 10 years in PRSP infections. The number of patients per sentinel hospital in MRSA infections showed little variation between months but evidenced a large variation in PRSP and MDRPA infections. The annual trend in the number of patients per sentinel hospital was increasing significantly for the 5-year period in MRSA and PRSP infections, but not in MDRPA infections. Conclusions: We revealed sex-age distributions of the patients reported to NESID in Japan, 2001-2005. An increasing incidence of MRSA and PRSP infections and monthly variation in PRSP and MDRPA infections were observed for the 5-year period. Extended observation would be necessary to confirm these trends and variations.
KW - Drug-resistant bacterial infections
KW - Methicillin-resistant Staphylococcus aureus (MRSA)
KW - Multi-drug-resistant Pseudomonas Aeruginosa (MDRPA)
KW - Penicillin-resistant Streptococcus Pneumoniae (PRSP)
KW - Sentinel surveillance
UR - http://www.scopus.com/inward/record.url?scp=40249119882&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40249119882&partnerID=8YFLogxK
U2 - 10.2188/jea.17.S42
DO - 10.2188/jea.17.S42
M3 - Article
C2 - 18239341
AN - SCOPUS:40249119882
SN - 0917-5040
VL - 17
SP - S42-S47
JO - Journal of epidemiology
JF - Journal of epidemiology
IS - SUPPL. 1
ER -