Epidemiology of carbapenem-resistant Enterobacteriaceae in hospitals of a large healthcare system in Miami, Florida from 2012 to 2016: Five years of experience with an internal registry

Adriana Jimenez, Mary Jo Trepka, L. Silvia Munoz-Price, Vukosava Pekovic, Boubakari Ibrahimou, Lilian M. Abbo, Octavio Martinez, Kathleen Sposato, Dennise dePascale, Armando Perez-Cardona, Christi L. McElheny, William C. Bachman, Erin L. Fowler, Yohei Doi, Kristopher Fennie

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Abstract

Background: Carbapenem-resistant Enterobacteriaceae (CRE) is an urgent public health threat globally. Limited data are available regarding the epidemiology of CRE in South Florida. We describe the epidemiology of CRE within a large public healthcare system in Miami, FL, the experience with an internal registry, active surveillance testing, and the impact of infection prevention practices. Methods: Retrospective cohort study in 4 hospitals from a large healthcare system in Miami-Dade County, FL from 2012 to 2016. The internal registry included all CRE cases from active surveillance testing from rectal and/or tracheal screening occurring in the intensive care units of 2 of the hospitals and clinical cultures across the healthcare system. All CRE cases were tagged in the electronic medical record and automatically entered into a platform for automatic infection control surveillance. The system alerted about new cases, readmissions, and transfers. Results: A total of 371 CRE cases were identified. The overall prevalence was 0.077 cases per 100 patient-admissions; the admission prevalence was 0.019 per 100 patient-admissions, and the incidence density was 1.46 cases per 10,000 patient-days. Rates increased during the first 3 years of the study and declined later to a lower level than at the beginning of study period. Conclusions: Active surveillance testing and the use of an internal registry facilitated prompt identification of cases contributing to control increasing rates of CRE by rapid implementation of infection prevention strategies.

Original languageEnglish
JournalAmerican Journal of Infection Control
DOIs
Publication statusAccepted/In press - 01-01-2020

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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    Jimenez, A., Trepka, M. J., Munoz-Price, L. S., Pekovic, V., Ibrahimou, B., Abbo, L. M., Martinez, O., Sposato, K., dePascale, D., Perez-Cardona, A., McElheny, C. L., Bachman, W. C., Fowler, E. L., Doi, Y., & Fennie, K. (Accepted/In press). Epidemiology of carbapenem-resistant Enterobacteriaceae in hospitals of a large healthcare system in Miami, Florida from 2012 to 2016: Five years of experience with an internal registry. American Journal of Infection Control. https://doi.org/10.1016/j.ajic.2020.04.013