Epstein-Barr virus-positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection-associated T/NK-cell lymphoproliferative disorder: A case report

Seiichi Kato, Tomoko Miyata, Katsuyoshi Takata, Satoko Shimada, Yoshinori Ito, Akihiro Tomita, Ahmed Ali Elsayed, Emiko Takahashi, Naoko Asano, Tomohiro Kinoshita, Hiroshi Kimura, Shigeo Nakamura

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Abstract

A 30-year-old female patient presented with intestinal Epstein-Barr virus (EBV)-positive cytotoxic T-cell lymphoma (EBV+ CTL), which was surgically resected. Fourteen years later, she returned to our hospital with hypersensitivity to mosquito bites and was diagnosed with chronic active EBV infection-associated T/NK-cell lymphoproliferative disorder (CAEBV/TNK-LPD). She developed systemic EBV+ CTL at age 47 years during the 2.5-year clinical course of CAEBV/TNK-LPD, despite multiagent chemotherapy and allogeneic stem cell transplantation. Afterward, she had a rapidly deteriorating clinical course and died at age 48 years. The immunophenotype of the EBV+ CTL was consistently a CD3, CD8, and cytotoxic molecule-positive type with the same clonality in polymerase chain reaction analysis of T-cell receptor-γ chain gene rearrangement. This is the first reported case of EBV+ CTL preceding the clinical presentation of CAEBV/TNK-LPD. The present case was unique in suggesting a close relationship between EBV+ CTL and chronic active EBV infection.

Original languageEnglish
Pages (from-to)2849-2852
Number of pages4
JournalHuman Pathology
Volume44
Issue number12
DOIs
Publication statusPublished - 01-12-2013
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Kato, S., Miyata, T., Takata, K., Shimada, S., Ito, Y., Tomita, A., Elsayed, A. A., Takahashi, E., Asano, N., Kinoshita, T., Kimura, H., & Nakamura, S. (2013). Epstein-Barr virus-positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection-associated T/NK-cell lymphoproliferative disorder: A case report. Human Pathology, 44(12), 2849-2852. https://doi.org/10.1016/j.humpath.2013.05.025