Epstein-Barr virus-positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection-associated T/NK-cell lymphoproliferative disorder: A case report

Seiichi Kato, Tomoko Miyata, Katsuyoshi Takata, Satoko Shimada, Yoshinori Ito, Akihiro Tomita, Ahmed Ali Elsayed, Emiko Takahashi, Naoko Asano, Tomohiro Kinoshita, Hiroshi Kimura, Shigeo Nakamura

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Abstract

A 30-year-old female patient presented with intestinal Epstein-Barr virus (EBV)-positive cytotoxic T-cell lymphoma (EBV+ CTL), which was surgically resected. Fourteen years later, she returned to our hospital with hypersensitivity to mosquito bites and was diagnosed with chronic active EBV infection-associated T/NK-cell lymphoproliferative disorder (CAEBV/TNK-LPD). She developed systemic EBV+ CTL at age 47 years during the 2.5-year clinical course of CAEBV/TNK-LPD, despite multiagent chemotherapy and allogeneic stem cell transplantation. Afterward, she had a rapidly deteriorating clinical course and died at age 48 years. The immunophenotype of the EBV+ CTL was consistently a CD3, CD8, and cytotoxic molecule-positive type with the same clonality in polymerase chain reaction analysis of T-cell receptor-γ chain gene rearrangement. This is the first reported case of EBV+ CTL preceding the clinical presentation of CAEBV/TNK-LPD. The present case was unique in suggesting a close relationship between EBV+ CTL and chronic active EBV infection.

Original languageEnglish
Pages (from-to)2849-2852
Number of pages4
JournalHuman Pathology
Volume44
Issue number12
DOIs
Publication statusPublished - 01-12-2013
Externally publishedYes

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Epstein-Barr Virus Infections
Lymphoproliferative Disorders
T-Cell Lymphoma
Human Herpesvirus 4
Natural Killer Cells
T-Cell Receptor Genes
Gene Rearrangement
Stem Cell Transplantation
Bites and Stings
Culicidae
Hypersensitivity
Drug Therapy
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Kato, Seiichi ; Miyata, Tomoko ; Takata, Katsuyoshi ; Shimada, Satoko ; Ito, Yoshinori ; Tomita, Akihiro ; Elsayed, Ahmed Ali ; Takahashi, Emiko ; Asano, Naoko ; Kinoshita, Tomohiro ; Kimura, Hiroshi ; Nakamura, Shigeo. / Epstein-Barr virus-positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection-associated T/NK-cell lymphoproliferative disorder : A case report. In: Human Pathology. 2013 ; Vol. 44, No. 12. pp. 2849-2852.
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abstract = "A 30-year-old female patient presented with intestinal Epstein-Barr virus (EBV)-positive cytotoxic T-cell lymphoma (EBV+ CTL), which was surgically resected. Fourteen years later, she returned to our hospital with hypersensitivity to mosquito bites and was diagnosed with chronic active EBV infection-associated T/NK-cell lymphoproliferative disorder (CAEBV/TNK-LPD). She developed systemic EBV+ CTL at age 47 years during the 2.5-year clinical course of CAEBV/TNK-LPD, despite multiagent chemotherapy and allogeneic stem cell transplantation. Afterward, she had a rapidly deteriorating clinical course and died at age 48 years. The immunophenotype of the EBV+ CTL was consistently a CD3, CD8, and cytotoxic molecule-positive type with the same clonality in polymerase chain reaction analysis of T-cell receptor-γ chain gene rearrangement. This is the first reported case of EBV+ CTL preceding the clinical presentation of CAEBV/TNK-LPD. The present case was unique in suggesting a close relationship between EBV+ CTL and chronic active EBV infection.",
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Kato, S, Miyata, T, Takata, K, Shimada, S, Ito, Y, Tomita, A, Elsayed, AA, Takahashi, E, Asano, N, Kinoshita, T, Kimura, H & Nakamura, S 2013, 'Epstein-Barr virus-positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection-associated T/NK-cell lymphoproliferative disorder: A case report', Human Pathology, vol. 44, no. 12, pp. 2849-2852. https://doi.org/10.1016/j.humpath.2013.05.025

Epstein-Barr virus-positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection-associated T/NK-cell lymphoproliferative disorder : A case report. / Kato, Seiichi; Miyata, Tomoko; Takata, Katsuyoshi; Shimada, Satoko; Ito, Yoshinori; Tomita, Akihiro; Elsayed, Ahmed Ali; Takahashi, Emiko; Asano, Naoko; Kinoshita, Tomohiro; Kimura, Hiroshi; Nakamura, Shigeo.

In: Human Pathology, Vol. 44, No. 12, 01.12.2013, p. 2849-2852.

Research output: Contribution to journalArticle

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T1 - Epstein-Barr virus-positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection-associated T/NK-cell lymphoproliferative disorder

T2 - A case report

AU - Kato, Seiichi

AU - Miyata, Tomoko

AU - Takata, Katsuyoshi

AU - Shimada, Satoko

AU - Ito, Yoshinori

AU - Tomita, Akihiro

AU - Elsayed, Ahmed Ali

AU - Takahashi, Emiko

AU - Asano, Naoko

AU - Kinoshita, Tomohiro

AU - Kimura, Hiroshi

AU - Nakamura, Shigeo

PY - 2013/12/1

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N2 - A 30-year-old female patient presented with intestinal Epstein-Barr virus (EBV)-positive cytotoxic T-cell lymphoma (EBV+ CTL), which was surgically resected. Fourteen years later, she returned to our hospital with hypersensitivity to mosquito bites and was diagnosed with chronic active EBV infection-associated T/NK-cell lymphoproliferative disorder (CAEBV/TNK-LPD). She developed systemic EBV+ CTL at age 47 years during the 2.5-year clinical course of CAEBV/TNK-LPD, despite multiagent chemotherapy and allogeneic stem cell transplantation. Afterward, she had a rapidly deteriorating clinical course and died at age 48 years. The immunophenotype of the EBV+ CTL was consistently a CD3, CD8, and cytotoxic molecule-positive type with the same clonality in polymerase chain reaction analysis of T-cell receptor-γ chain gene rearrangement. This is the first reported case of EBV+ CTL preceding the clinical presentation of CAEBV/TNK-LPD. The present case was unique in suggesting a close relationship between EBV+ CTL and chronic active EBV infection.

AB - A 30-year-old female patient presented with intestinal Epstein-Barr virus (EBV)-positive cytotoxic T-cell lymphoma (EBV+ CTL), which was surgically resected. Fourteen years later, she returned to our hospital with hypersensitivity to mosquito bites and was diagnosed with chronic active EBV infection-associated T/NK-cell lymphoproliferative disorder (CAEBV/TNK-LPD). She developed systemic EBV+ CTL at age 47 years during the 2.5-year clinical course of CAEBV/TNK-LPD, despite multiagent chemotherapy and allogeneic stem cell transplantation. Afterward, she had a rapidly deteriorating clinical course and died at age 48 years. The immunophenotype of the EBV+ CTL was consistently a CD3, CD8, and cytotoxic molecule-positive type with the same clonality in polymerase chain reaction analysis of T-cell receptor-γ chain gene rearrangement. This is the first reported case of EBV+ CTL preceding the clinical presentation of CAEBV/TNK-LPD. The present case was unique in suggesting a close relationship between EBV+ CTL and chronic active EBV infection.

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