Epstein-Barr virus-related Hodgkin's disease showing B cell lineage in an immunosuppressive patient seropositive for HTLV-I

Tetsuya Murata, Shigeo Nakamura, Hiroya Kato, Yasushi Yatabe, Taizo Shiraishi, Makoto Kuroda, Ryuichi Yatani, Taizan Suchi

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5 Citations (Scopus)

Abstract

A case of Hodgkin's disease (HD), lymphocyte depression (LD) type in an immunosuppressive patient is described. The patient was a 48-year-old male and his parents were born in the Kyushu area, which is an endemic area for adult T cell lymphomaleukemia (ATL). He was seropositive for ATL virus (ATLV, also referred to as HTLV-I) and showed a marked immunosuppressive condition. He developed LD-HD and Pheumocystis carinii pneumonia, and died due to respiratory failure. The immunohistochemical and in situ hybridization analyses revealed that the Reed-Sternberg-like cells in the lymph mode biopsy sample were positive for Ber-H2 (CD30), Leu-M1 (CD15), L-26 (CD20), Bcl-2, p53 and EBER, the vital genome of Epstein-Barr virus (EBV).

Original languageEnglish
Pages (from-to)801-805
Number of pages5
JournalPathology International
Volume47
Issue number11
DOIs
Publication statusPublished - 01-01-1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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