@article{dc161160dd9f4d5c8e1fea605578e3c9,
title = "Epstein–Barr virus (EBV) deletions as biomarkers of response to treatment of chronic active EBV",
abstract = "Chronic active Epstein–Barr virus (CAEBV) disease is a rare condition characterised by persistent EBV infection in previously healthy individuals. Defective EBV genomes were found in East Asian patients with CAEBV. In the present study, we sequenced 14 blood EBV samples from three UK patients with CAEBV, comparing the results with saliva CAEBV samples and other conditions. We observed EBV deletions in blood, some of which may disrupt viral replication, but not saliva in CAEBV. Deletions were lost overtime after successful treatment. These findings are compatible with CAEBV being associated with the evolution and persistence of EBV+ haematological clones that are lost on successful treatment.",
author = "Cristina Venturini and Houldcroft, {Charlotte J.} and Arina Lazareva and Fanny Wegner and Sofia Morfopoulou and Amrolia, {Persis J.} and Zainab Golwala and Anupama Rao and Marks, {Stephen D.} and Jacob Simmonds and Tetsushi Yoshikawa and Farrell, {Paul J.} and Cohen, {Jeffrey I.} and Worth, {Austen J.} and Judith Breuer",
note = "Funding Information: We thank Prof. Richard Goldstein [Division of Infection and Immunity, University College London (UCL)] and Dr Daniel P. Depledge (NYU Department of Medicine) for insightful comments and discussion. We acknowledge the support of the UK Medical Research Council (MRC)/National Institute for Health Research (NIHR) funded Pathogen Genomics Unit. Cristina Venturini was supported by the Wellcome Trust Collaborative Award (204870/Z/16/Z); Sofia Morfopoulou by a W.T. Henry Wellcome fellowship (206478/Z/17/Z). Paul J. Farrell was supported by MRC grant MR/S022597/1 and by NIHR Imperial Biomedical Research Centre (BRC). Judith Breueris supported by the NIHR UCL/UCLH BRC. This work was supported by the intramural research program of the National Institute of Allergy and Infectious Diseases. Funding Information: We thank Prof. Richard Goldstein [Division of Infection and Immunity, University College London (UCL)] and Dr Daniel P. Depledge (NYU Department of Medicine) for insightful comments and discussion. We acknowledge the support of the UK Medical Research Council (MRC)/National Institute for Health Research (NIHR) funded Pathogen Genomics Unit. Cristina Venturini was supported by the Wellcome Trust Collaborative Award (204870/Z/16/Z); Sofia Morfopoulou by a W.T. Henry Wellcome fellowship (206478/Z/17/Z). Paul J. Farrell was supported by MRC grant MR/S022597/1 and by NIHR Imperial Biomedical Research Centre (BRC). Judith Breueris supported by the NIHR UCL/UCLH BRC. This work was supported by the intramural research program of the National Institute of Allergy and Infectious Diseases. Publisher Copyright: {\textcopyright} 2021 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.",
year = "2021",
month = oct,
doi = "10.1111/bjh.17790",
language = "English",
volume = "195",
pages = "249--255",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "2",
}