Epstein–Barr virus (EBV) deletions as biomarkers of response to treatment of chronic active EBV

Cristina Venturini; Charlotte J. Houldcroft; Arina Lazareva; Fanny Wegner; Sofia Morfopoulou; Persis J. Amrolia; Zainab Golwala; Anupama Rao; Stephen D. Marks; Jacob Simmonds; Tetsushi Yoshikawa; Paul J. Farrell; Jeffrey I. Cohen; Austen J. Worth; Judith Breuer

doi:10.1111/bjh.17790

Epstein–Barr virus (EBV) deletions as biomarkers of response to treatment of chronic active EBV

Cristina Venturini, Charlotte J. Houldcroft, Arina Lazareva, Fanny Wegner, Sofia Morfopoulou, Persis J. Amrolia, Zainab Golwala, Anupama Rao, Stephen D. Marks, Jacob Simmonds, Tetsushi Yoshikawa, Paul J. Farrell, Jeffrey I. Cohen, Austen J. Worth, Judith Breuer

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Chronic active Epstein–Barr virus (CAEBV) disease is a rare condition characterised by persistent EBV infection in previously healthy individuals. Defective EBV genomes were found in East Asian patients with CAEBV. In the present study, we sequenced 14 blood EBV samples from three UK patients with CAEBV, comparing the results with saliva CAEBV samples and other conditions. We observed EBV deletions in blood, some of which may disrupt viral replication, but not saliva in CAEBV. Deletions were lost overtime after successful treatment. These findings are compatible with CAEBV being associated with the evolution and persistence of EBV⁺ haematological clones that are lost on successful treatment.

Original language	English
Pages (from-to)	249-255
Number of pages	7
Journal	British Journal of Haematology
Volume	195
Issue number	2
DOIs	https://doi.org/10.1111/bjh.17790
Publication status	Published - 10-2021
Externally published	Yes

All Science Journal Classification (ASJC) codes

Hematology

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10.1111/bjh.17790

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Venturini, C., Houldcroft, C. J., Lazareva, A., Wegner, F., Morfopoulou, S., Amrolia, P. J., Golwala, Z., Rao, A., Marks, S. D., Simmonds, J., Yoshikawa, T., Farrell, P. J., Cohen, J. I., Worth, A. J., & Breuer, J. (2021). Epstein–Barr virus (EBV) deletions as biomarkers of response to treatment of chronic active EBV. British Journal of Haematology, 195(2), 249-255. https://doi.org/10.1111/bjh.17790

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title = "Epstein–Barr virus (EBV) deletions as biomarkers of response to treatment of chronic active EBV",

abstract = "Chronic active Epstein–Barr virus (CAEBV) disease is a rare condition characterised by persistent EBV infection in previously healthy individuals. Defective EBV genomes were found in East Asian patients with CAEBV. In the present study, we sequenced 14 blood EBV samples from three UK patients with CAEBV, comparing the results with saliva CAEBV samples and other conditions. We observed EBV deletions in blood, some of which may disrupt viral replication, but not saliva in CAEBV. Deletions were lost overtime after successful treatment. These findings are compatible with CAEBV being associated with the evolution and persistence of EBV+ haematological clones that are lost on successful treatment.",

keywords = "Epstein–Barr virus, chronic active EBV, defective viral genome",

author = "Cristina Venturini and Houldcroft, {Charlotte J.} and Arina Lazareva and Fanny Wegner and Sofia Morfopoulou and Amrolia, {Persis J.} and Zainab Golwala and Anupama Rao and Marks, {Stephen D.} and Jacob Simmonds and Tetsushi Yoshikawa and Farrell, {Paul J.} and Cohen, {Jeffrey I.} and Worth, {Austen J.} and Judith Breuer",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.",

year = "2021",

month = oct,

doi = "10.1111/bjh.17790",

language = "English",

volume = "195",

pages = "249--255",

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Venturini, C, Houldcroft, CJ, Lazareva, A, Wegner, F, Morfopoulou, S, Amrolia, PJ, Golwala, Z, Rao, A, Marks, SD, Simmonds, J, Yoshikawa, T, Farrell, PJ, Cohen, JI, Worth, AJ & Breuer, J 2021, 'Epstein–Barr virus (EBV) deletions as biomarkers of response to treatment of chronic active EBV', British Journal of Haematology, vol. 195, no. 2, pp. 249-255. https://doi.org/10.1111/bjh.17790

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T1 - Epstein–Barr virus (EBV) deletions as biomarkers of response to treatment of chronic active EBV

AU - Venturini, Cristina

AU - Houldcroft, Charlotte J.

AU - Lazareva, Arina

AU - Wegner, Fanny

AU - Morfopoulou, Sofia

AU - Amrolia, Persis J.

AU - Golwala, Zainab

AU - Rao, Anupama

AU - Marks, Stephen D.

AU - Simmonds, Jacob

AU - Yoshikawa, Tetsushi

AU - Farrell, Paul J.

AU - Cohen, Jeffrey I.

AU - Worth, Austen J.

AU - Breuer, Judith

PY - 2021/10

Y1 - 2021/10

N2 - Chronic active Epstein–Barr virus (CAEBV) disease is a rare condition characterised by persistent EBV infection in previously healthy individuals. Defective EBV genomes were found in East Asian patients with CAEBV. In the present study, we sequenced 14 blood EBV samples from three UK patients with CAEBV, comparing the results with saliva CAEBV samples and other conditions. We observed EBV deletions in blood, some of which may disrupt viral replication, but not saliva in CAEBV. Deletions were lost overtime after successful treatment. These findings are compatible with CAEBV being associated with the evolution and persistence of EBV+ haematological clones that are lost on successful treatment.

AB - Chronic active Epstein–Barr virus (CAEBV) disease is a rare condition characterised by persistent EBV infection in previously healthy individuals. Defective EBV genomes were found in East Asian patients with CAEBV. In the present study, we sequenced 14 blood EBV samples from three UK patients with CAEBV, comparing the results with saliva CAEBV samples and other conditions. We observed EBV deletions in blood, some of which may disrupt viral replication, but not saliva in CAEBV. Deletions were lost overtime after successful treatment. These findings are compatible with CAEBV being associated with the evolution and persistence of EBV+ haematological clones that are lost on successful treatment.

KW - Epstein–Barr virus

KW - chronic active EBV

KW - defective viral genome

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Epstein–Barr virus (EBV) deletions as biomarkers of response to treatment of chronic active EBV

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