Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils

Nobuyuki Shimizu, Yuzuru Ikehara, Ken Ichi Inada, Hayao Nakanishi, Tetsuya Tsukamoto, Koji Nozaki, Michio Kaminishi, Shu Kuramoto, Atsushi Sugiyama, Tsutomu Katsuyama, Masae Tatematsu

Research output: Contribution to journalArticlepeer-review

146 Citations (Scopus)

Abstract

To investigate the nature of the link between Helicobacter pylori (Hp) infection and stomach carcinogenesis, a study of the glandular stomach of Mongolian gerbils (MGs) was performed. MGs were treated with N-methyl-N- nitrosourea (MNU), followed by inoculation with Hp (groups 1 and 2) or without Hp (group 3), or infected with Hp (groups 4 and 5) or inoculation without Hp (group 6) followed by MNU administration. At week 21, the animals in groups 2 and 5 underwent an eradication procedure. At week 50, the incidences of adenocarcinomas in group 1 (15 of 23) and group 4 (9 of 26) were significantly higher than in group 3 (1 of 15) and group 6 (1 of 18), respectively. Moreover, those in group 2 (5 of 24) and group 5 (2 of 22) were lower than in groups 1 and 4, respectively. This study shows that Hp eradication may be useful as a prevention approach against stomach cancer.

Original languageEnglish
Pages (from-to)1512-1514
Number of pages3
JournalCancer Research
Volume60
Issue number6
Publication statusPublished - 15-03-2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils'. Together they form a unique fingerprint.

Cite this