Escape of leukemia blasts from HLA-specific CTL pressure in a recipient of HLA one locus-mismatched bone marrow transplantation

Tomonori Kato, Seitaro Terakura, Makoto Murata, Kyoko Sugimoto, Miho Murase, Chisako Iriyama, Akihiro Tomita, Akihiro Abe, Momoko Suzuki, Tetsuya Nishida, Tomoki Naoe

Research output: Contribution to journalArticle

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Abstract

A case of leukemia escape from an HLA-specific cytotoxic T lymphocyte (CTL) response in a recipient of bone marrow transplantation is presented. Only the expression of HLA-B51, which was a mismatched HLA locus in the graft-versus-host direction, was down-regulated in post-transplant leukemia blasts compared with that in pre-transplant blasts. All CTL clones, that were isolated from the recipient's blood when acute graft-versus-host disease developed, recognized the mismatched B *51:01 molecule in a peptide-dependent manner. The pre-transplant leukemia blasts were lysed by CTL clones, whereas the post-transplant leukemia blasts were not lysed by any CTL clones. The IFN-γ ELISPOT assay revealed that B *51:01-reactive T lymphocytes accounted for the majority of the total alloreactive T lymphocytes in the blood just before leukemia relapse. These data suggest that immune escape of leukemia blasts from CTL pressure toward a certain HLA molecule can lead to clinical relapse after bone marrow transplantation.

Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalCellular Immunology
Volume276
Issue number1-2
DOIs
Publication statusPublished - 01-03-2012
Externally publishedYes

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Cytotoxic T-Lymphocytes
Bone Marrow Transplantation
Leukemia
Pressure
Transplants
Clone Cells
HLA-B51 Antigen
T-Lymphocytes
Enzyme-Linked Immunospot Assay
Recurrence
Graft vs Host Disease
Peptides

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Kato, Tomonori ; Terakura, Seitaro ; Murata, Makoto ; Sugimoto, Kyoko ; Murase, Miho ; Iriyama, Chisako ; Tomita, Akihiro ; Abe, Akihiro ; Suzuki, Momoko ; Nishida, Tetsuya ; Naoe, Tomoki. / Escape of leukemia blasts from HLA-specific CTL pressure in a recipient of HLA one locus-mismatched bone marrow transplantation. In: Cellular Immunology. 2012 ; Vol. 276, No. 1-2. pp. 75-82.
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Kato, T, Terakura, S, Murata, M, Sugimoto, K, Murase, M, Iriyama, C, Tomita, A, Abe, A, Suzuki, M, Nishida, T & Naoe, T 2012, 'Escape of leukemia blasts from HLA-specific CTL pressure in a recipient of HLA one locus-mismatched bone marrow transplantation', Cellular Immunology, vol. 276, no. 1-2, pp. 75-82. https://doi.org/10.1016/j.cellimm.2012.03.011

Escape of leukemia blasts from HLA-specific CTL pressure in a recipient of HLA one locus-mismatched bone marrow transplantation. / Kato, Tomonori; Terakura, Seitaro; Murata, Makoto; Sugimoto, Kyoko; Murase, Miho; Iriyama, Chisako; Tomita, Akihiro; Abe, Akihiro; Suzuki, Momoko; Nishida, Tetsuya; Naoe, Tomoki.

In: Cellular Immunology, Vol. 276, No. 1-2, 01.03.2012, p. 75-82.

Research output: Contribution to journalArticle

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AU - Sugimoto, Kyoko

AU - Murase, Miho

AU - Iriyama, Chisako

AU - Tomita, Akihiro

AU - Abe, Akihiro

AU - Suzuki, Momoko

AU - Nishida, Tetsuya

AU - Naoe, Tomoki

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N2 - A case of leukemia escape from an HLA-specific cytotoxic T lymphocyte (CTL) response in a recipient of bone marrow transplantation is presented. Only the expression of HLA-B51, which was a mismatched HLA locus in the graft-versus-host direction, was down-regulated in post-transplant leukemia blasts compared with that in pre-transplant blasts. All CTL clones, that were isolated from the recipient's blood when acute graft-versus-host disease developed, recognized the mismatched B *51:01 molecule in a peptide-dependent manner. The pre-transplant leukemia blasts were lysed by CTL clones, whereas the post-transplant leukemia blasts were not lysed by any CTL clones. The IFN-γ ELISPOT assay revealed that B *51:01-reactive T lymphocytes accounted for the majority of the total alloreactive T lymphocytes in the blood just before leukemia relapse. These data suggest that immune escape of leukemia blasts from CTL pressure toward a certain HLA molecule can lead to clinical relapse after bone marrow transplantation.

AB - A case of leukemia escape from an HLA-specific cytotoxic T lymphocyte (CTL) response in a recipient of bone marrow transplantation is presented. Only the expression of HLA-B51, which was a mismatched HLA locus in the graft-versus-host direction, was down-regulated in post-transplant leukemia blasts compared with that in pre-transplant blasts. All CTL clones, that were isolated from the recipient's blood when acute graft-versus-host disease developed, recognized the mismatched B *51:01 molecule in a peptide-dependent manner. The pre-transplant leukemia blasts were lysed by CTL clones, whereas the post-transplant leukemia blasts were not lysed by any CTL clones. The IFN-γ ELISPOT assay revealed that B *51:01-reactive T lymphocytes accounted for the majority of the total alloreactive T lymphocytes in the blood just before leukemia relapse. These data suggest that immune escape of leukemia blasts from CTL pressure toward a certain HLA molecule can lead to clinical relapse after bone marrow transplantation.

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