Esculetin (dihydroxycoumarin) inhibits the production of matrix metalloproteinases in cartilage explants, and oral administration of its prodrug, CPA-926, suppresses cartilage destruction in rabbit experimental osteoarthritis

Harumoto Yamada, Koju Watanabe, Tsuyoshi Saito, Haruhisa Hayashi, Yoshiaki Niitani, Toshiyuki Kikuchi, Akira Ito, Kyosuke Fujikawa, L. Stefan Lohmander

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