TY - JOUR
T1 - Essential role of placental leucine aminopeptidase in gynecologic malignancy
AU - Mizutani, Shigehiko
AU - Shibata, Kiyosumi
AU - Kikkawa, Fumitaka
AU - Hattori, Akira
AU - Tsujimoto, Masafumi
AU - Ishii, Masakazu
AU - Kobayashi, Hiroshi
PY - 2007/4
Y1 - 2007/4
N2 - The M1 aminopeptidase family is important for the maturation or degradation of bioactive peptides by hydrolyzing their N-terminal amino acids. Some investigators have studied aminopeptidase in the maintenance of homeostasis including maintenance of normal pregnancy, memory retention, blood pressure regulation and antigen presentation. However, there are a few reports on the relation between the M1 aminopeptidase family and carcinoma. In addition to its capacity to degrade a range of peptides, placental-leucine aminopeptidase (P-LAP) has novel functions that impact on normal cells and neoplastic cells. P-LAP is the focus of this review.
AB - The M1 aminopeptidase family is important for the maturation or degradation of bioactive peptides by hydrolyzing their N-terminal amino acids. Some investigators have studied aminopeptidase in the maintenance of homeostasis including maintenance of normal pregnancy, memory retention, blood pressure regulation and antigen presentation. However, there are a few reports on the relation between the M1 aminopeptidase family and carcinoma. In addition to its capacity to degrade a range of peptides, placental-leucine aminopeptidase (P-LAP) has novel functions that impact on normal cells and neoplastic cells. P-LAP is the focus of this review.
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U2 - 10.1517/14728222.11.4.453
DO - 10.1517/14728222.11.4.453
M3 - Review article
C2 - 17373876
AN - SCOPUS:33947699912
SN - 1472-8222
VL - 11
SP - 453
EP - 461
JO - Expert Opinion on Therapeutic Targets
JF - Expert Opinion on Therapeutic Targets
IS - 4
ER -