Essential role of placental leucine aminopeptidase in gynecologic malignancy

Shigehiko Mizutani, Kiyosumi Shibata, Fumitaka Kikkawa, Akira Hattori, Masafumi Tsujimoto, Masakazu Ishii, Hiroshi Kobayashi

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)


The M1 aminopeptidase family is important for the maturation or degradation of bioactive peptides by hydrolyzing their N-terminal amino acids. Some investigators have studied aminopeptidase in the maintenance of homeostasis including maintenance of normal pregnancy, memory retention, blood pressure regulation and antigen presentation. However, there are a few reports on the relation between the M1 aminopeptidase family and carcinoma. In addition to its capacity to degrade a range of peptides, placental-leucine aminopeptidase (P-LAP) has novel functions that impact on normal cells and neoplastic cells. P-LAP is the focus of this review.

Original languageEnglish
Pages (from-to)453-461
Number of pages9
JournalExpert Opinion on Therapeutic Targets
Issue number4
Publication statusPublished - 01-04-2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry


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